Jervine
Catalog No.
A8656
Hedgehog signaling Inhibitor
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Inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 425.6 |
| Cas No. | 469-59-0 |
| Formula | C27H39NO3 |
| Solubility | ≥14.55 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethylspiro[1,2,3,4,6,6a,6b,7,8,11a-decahydrobenzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-11-one |
| SDF | Download SDF |
| Canonical SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5C(=O)C4=C3C)C)O)C)NC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
