HOAt
Catalog No.
A7024
coupling activator for racemization-free coupling in peptide synthesis
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A coupling activator for racemization-free coupling in peptide synthesis; An additive for peptide segment coupling in in reducing the extent of configurational loss at the reactive carboxylic acid residue. Carpino L A etc. works demonstrated that the DIC/HOAt system is more effective in preserving configuration for peptide segment coupling than the analogous DIC/HOBt system
in DMF and DCM. [1]
Reference:
Carpino L A, El-Faham A.? The diisopropylcarbodiimide/1-hydroxy-7-azabenzotriazole system: segment coupling and stepwise peptide assembly[J]. Tetrahedron, 1999, 55(22): 6813-6830.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 136.11 |
| Cas No. | 39968-33-7 |
| Formula | C5H4N4O |
| Solubility | ≥3.62 mg/mL in H2O with ultrasonic; ≥6.81 mg/mL in DMSO; ≥9.29 mg/mL in EtOH with ultrasonic |
| Chemical Name | 3-hydroxytriazolo[4,5-b]pyridine |
| SDF | Download SDF |
| Canonical SMILES | C1=CC2=C(N=C1)N(N=N2)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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