Triptonide
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 358.39 |
| Cas No. | 38647-11-9 |
| Formula | C20H22O6 |
| Synonyms | NSC 165677; PG 492 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥16.35 mg/mL in DMSO |
| Chemical Name | (5bS,6aS,7aS,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-1,5b,6,6a,8a,9a,9b,10b-octahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-3,8(2H,5H)-dione |
| SDF | Download SDF |
| Canonical SMILES | CC([C@]12[C@@H](O2)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@]5([H])C[C@H]7[C@@]4(O7)C1=O)COC6=O)C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
|
Cell lines |
Human B-lymphoma Raji and T-lymphoma Jurkat cell lines |
|
Reaction Conditions |
0 ~ 80 nM for 3 or 6 days |
|
Applications |
These two lymphoma cell lines were very sensitive to triptonide in a dose-dependent manner, with the IC50 of 11.4 nM at 3 days and 5.7 nM at 6 days in B-lymphoma Raji cells, and 11.1 nM at 3 days and 4.8 nM at 6 days in T-lymphoma Jurkat cells, respectively. |
| Animal experiment:[1] | |
|
Animal models |
Eight-week-old female NOD/SCID mice (18 ~ 22 g) xenografted with Raji cells |
|
Dosage form |
5 mg/kg Once daily by intraperitoneal injection for 34 days |
|
Applications |
Triptonide at a dose of 5 mg/kg/day almost completely inhibited the lymphoma growth in human lymphoma cells-xenografted mice without obvious side effects. Moreover, the tumors in 6 mice among the 8 xenografted mice were completely eradicated in vivo. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Yang P, Dong F, Zhou Q. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology Letters, 2017, 278: 9-17. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
