Amikacin

Catalog No.

B3431

aminoglycoside antibiotic

Grouped product items
Size	Price	Stock	Qty
1g	$65.00	In stock
5g	$260.00	Ship with 5-10 days

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Amikacin(BAY416651) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin A.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	585.6
Cas No.	37517-28-5
Formula	C₂₂H₄₃N₅O₁₃
Solubility	insoluble in EtOH; insoluble in DMSO; ≥5.86 mg/mL in H2O
Chemical Name	(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
SDF	Download SDF
Canonical SMILES	C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Cell experiment [1]:
Cell lines	Klebsiella pneumoniae
Preparation method	The solubility of this compound in DMSO is < 5.86mg/ml. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
Applications	Of all Ags, amikacin (Ak) is the most resistant to the action of Ag-modifying enzymes. However, AAC (6')-I type enzymes (a group of 6'-N-acetyltransferases) can utilize Ak as substrate and confer resistance to this antibiotic in addition to other Ags.
References: [1]. Tolmasky ME. Bacterial resistance to aminoglycosides and beta-lactams: the Tn1331 transposon paradigm. Front Biosci. 2000 Jan 1;5: D20-9. Review. PubMed PMID: 10702385.

Purity = 99.29%