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TCS JNK 5a
TCS JNK 5a is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 7.5, respectively [1].
c-Jun N-terminal kinases (JNK) belong to the mitogen-activated protein kinase (MAPK) family. JNK1 and JNK2 are widely expressed, whereas JNK3 is mainly expressed in the brain and plays an important role to mediate neurodegeneration such as Alzheimer’s Disease and Parkinson’s Disease [1].
TCS JNK 5a is a selective JNK2 and JNK3 inhibitor. TCS JNK 5a exhibited selective against JNK1 and p38α with pIC50 values of 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α, respectively. Also, TCS JNK 5a was inactive at EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3β and PLK1 with pIC50 values of < 5.0 [1].
Reference:
[1]. Angell RM, Atkinson FL, Brown MJ, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett, 2007, 17(5): 1296-1301.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 332.42 |
| Cas No. | 312917-14-9 |
| Formula | C20H16N2OS |
| Solubility | ≥16.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide |
| SDF | Download SDF |
| Canonical SMILES | C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | TCS JNK 5a(JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3 with pIC50 values of 6.7 and 6.5, respectively. | |||||
| Targets | JNK3 | JNK2 | ||||
| IC50 | (pIC50=6.5) | (pIC50=6.7) | ||||
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Chemical structure
