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Pancuronium dibromide

Catalog No.
B1612
AChR antagonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$55.00
In stock
Evaluation Sample
$30.00
In stock
25mg
$68.00
In stock
50mg
$119.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. Pancuroni

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt732.67
Cas No.15500-66-0
FormulaC35H60N2O4·2Br
Solubility≥36.63 mg/mL in DMSO; ≥49.4 mg/mL in H2O; ≥58.1 mg/mL in EtOH
Chemical Name[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;dibromide
SDFDownload SDF
Canonical SMILESCC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment [1]:

Animal models

Rats

Dosage form

2 mg/kg, i.v.

Application

Two effects of pancuronium bromide on heart rate in vivo: A short-lasting injection effect, which may be due to an indirect sympathomimetic action, and a longer-lasting potentiation of cardiac sympathetic responses which is at least partly due to blockade of neuronal noradrenaline uptake.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Docherty JR, McGrath JC. Potentiation of cardiac sympathetic nerve responses in vivo by pancuronium bromide. Br J Pharmacol. 1977 Nov;61(3):472P-473P.

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