Lidocaine
Anasthetic and class Ib antiarrhythmic agent.?Blocks voltage-gated sodium channels in the inactivated state.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 234.34 |
| Cas No. | 137-58-6 |
| Formula | C14H22N2O |
| Solubility | insoluble in H2O; ≥11.72 mg/mL in DMSO; ≥227.27 mg/mL in EtOH |
| Chemical Name | 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide |
| SDF | Download SDF |
| Canonical SMILES | CCN(CC)CC(=O)NC1=C(C=CC=C1C)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1,2]: | |
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Cell lines |
Fresh bovine articular chondrocytes, sarcoplasmic reticulum |
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Preparation method |
The solubility of this compound in DMSO is >11.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
1% or 2% lidocaine, 30 minutes |
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Applications |
Lidocaine (1%, 15-minute) decreased chondrocyte viability. Longer exposures to 1% and 2% lidocaine further reduced chondrocyte viability. Lidocaine (40 μM) showed reverse frequency-dependent depression of myocardial contractility. Lidocaine(40 μM, 100 μM) caused a marked depression of the late-peaking contractile responses, attributed to Ca2+ release from the sarcoplasmic reticulum. |
| Animal experiment [3]: | |
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Animal models |
Dogs with 2-hour-old myocardial infarctions |
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Dosage form |
Intravenous bolus injection, 2-8 μg/ml |
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Application |
Lidocaine prolonged the Q-EG intervals in the infarcted zones of the heart 17-26% at peak effect, but it had no effect on the Q-EG intervals in the normal zone except for a slight (1.5%) prolongation shortly after the initial intravenous bolus injection. Lidocaine prolonged the effective refractory period of the infarcted zone 23% at peak effect but had no effect on the effective refractory period of the normal zone. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Karpie J C, Chu C R. Lidocaine exhibits dose-and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro[J]. The American journal of sports medicine, 2007, 35(10): 1622-1627. [2]. Lynch III C. Depression of myocardial contractility in vitro by bupivacaine, etidocaine, and lidocaine[J]. Anesthesia & Analgesia, 1986, 65(6): 551-559. [3]. Kupersmith J, Antman E M, Hoffman B F. In vivo electrophysiological effects of lidocaine in canine acute myocardial infarction[J]. Circulation research, 1975, 36(1): 84-91. |
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Quality Control & MSDS
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Chemical structure
