SKF-96365 hydrochloride is a non-selective Transient Receptor Potential (TRP) channel blocker, capable of inhibiting the activity of a variety of TRP channels, and is widely used to study the mechanism of intracellular calcium ion flow. In addition, SKF-96365 is also a potent SOCE (store-operated Ca2 + entry) inhibitor. SOCE is an important pathway for intracellular calcium ion replenishment and is usually activated when the calcium reservoir of the endoplasmic reticulum is depleted. By inhibiting SOCE, SKF-96365 can reduce the entry of calcium ions into cells, affecting a variety of physiological processes such as cell proliferation, differentiation, and apoptosis. Because of its effect on calcium signaling pathways, SKF-96365 has important applications in the study of cardiovascular diseases, immune responses, and neurodegenerative diseases.