UCN-02
UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, which has been first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite [1]. UCN-02 is protein kinase C inhibitor [1].
Protein kinase C (PKC), which can phosphorylate serine and threonine, is a family of protein kinase enzymes involved in regulating the function of other proteins. Protein kinase C plays an important role in several signal transduction cascades. Protein kinase C has been implicated in modulating membrane structure events, mediating immune responses, regulating transcription, learning and memory, and regulating cell growth [2].
UCN-02 inhibited protein kinase C with a slightly reduced potency than UCN-01. The IC50 values were 62 and 4.1 nM for UNC-02 and UCN-01, respectively. UCN-02 was cytotoxic to the growth of HeLa S3 cells.
References:
[1] Takahashi, I.?,Saitoh, Y.,Yoshida, M., et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J.Antibiot.(Tokyo) 42(4), 571-576 (1989).
[2] Newton A C.? Protein kinase C: structure, function, and regulation[J]. Journal of Biological Chemistry, 1995, 270(48): 28495-28498.
| Physical Appearance | A solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Storage | Store at -20°C |
| M.Wt | 482.5 |
| Cas No. | 121569-61-7 |
| Formula | C28H26N4O4 |
| Synonyms | 7-epi-hydroxy Staurosporine |
| Solubility | Soluble in DMSO |
| Chemical Name | (3S,9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
| SDF | Download SDF |
| Canonical SMILES | [H][C@]12N(C3=C(N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C4=C5C=CC=C4)C5=C([C@H](O)NC6=O)C6=C37)C8=C7C=CC=C8 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥ 95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
