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Doramectin

Catalog No.
A3371
Antiparasitic antibiotic
Grouped product items
SizePriceStock Qty
5g
$71.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt899.11
Cas No.117704-25-3
FormulaC50H74O14
SynonymsDectomax
Solubility≥89.9 mg/mL in DMSO; insoluble in H2O; ≥14.43 mg/mL in EtOH with gentle warming
SDFDownload SDF
Canonical SMILESCC1/C=C/C=C2COC3C\2(O)C(C(OC4CC(OC5(C=CC(C)C(C6CCCCC6)O5)C4)C/C=C(C)/C1OC7CC(OC)C(OC8CC(OC)C(O)C(C)O8)C(C)O7)=O)C=C(C)C3O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Animal experiment [1]：

Animal models

Dogs infected by oesophageal spirocercosis

Dosage form

0.5 mg/kg (p.o.),once daily for 42 days

Application

After 42 days, nodules in 13 dogs subsided. After another 42 days of treatment, 5 of the remaining 7 dogs eliminated nodules. In the remaining two dogs, treatment continued for another 42 days (a total of 126 days), which completely resolved the problem. No adverse events related to treatment were observed. This study concluded that doramectin at 0.5 mg / kg once a day was effective in eliminating Spirocerca lupi in dogs.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Lobetti R. Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. doi: 10.1016/j.tvjl.2011.09.002. Epub 2011 Oct 14. PMID: 22000593.

Quality Control