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- Marbofloxacin
Marbofloxacin
Marbofloxacin is a fluorinated, quinolone antibacterial.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 362.36 |
| Cas No. | 115550-35-1 |
| Formula | C17H19FN4O4 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥6.18 mg/mL in DMSO with gentle warming |
| Chemical Name | 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,3,4]oxadiazino[6,5,4-ij]quinoline-6-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | FC1=C(C2=C(C3=C1[H])N(C([H])=C(C(O[H])=O)C3=O)N(C([H])([H])[H])C([H])([H])O2)N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
L.infantum parasite |
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Preparation method |
The solubility of this compound in DMSO is ≥6.2mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
1, 5,10, 50 and 100 mg/ml |
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Applications |
At 26 ° C, marbofloxacin was more effective than meglumine antimoniate and sodium stibogluconate in inhibiting L.infantum promastigotes ;compared with MGA and Sbb, 2log and 3log reductions were observed. At a final concentration of 100 mg / ml, marbofloxacin dramatically changes the structure of the parasite after 48 hours of incubation, making it round and inhibiting the proliferation of the promastigotes. This effect is irreversible. The treated parasites did not restore their activity and did not proliferate further even after washing treatment and after 72 hours incubation in fresh medium without marbofloxacin. |
| Animal experiment [1]: | |
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Animal models |
Ponies infected with S. aureus |
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Dosage form |
6 mg/kg (i.v.), once daily for 7 day |
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Application |
The results showed that marbofloxacin is not effective in treating S.aureus infection in the pony tissue structure. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Vouldoukis I, Rougier S, Dugas B, Pino P, Mazier D, Woehrlé F. Canine visceral leishmaniasis: comparison of in vitro leishmanicidal activity of marbofloxacin, meglumine antimoniate and sodium stibogluconate. Vet Parasitol. 2006 Jan 30;135(2):137-46. Epub 2005 Oct 19. PubMed PMID: 16242844. [2]. Voermans M, van Soest JM, van Duijkeren E, Ensink JM. Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies. J Vet Pharmacol Ther. 2006 Dec;29(6):555-60. PubMed PMID: 17083460. |
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Quality Control & MSDS
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Chemical structure
