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BzATP (ammonium salt)

Catalog No.
B7358
A P2X7 receptor agonist
Grouped product items
SizePriceStock Qty
1mg
$60.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

BzATP (ammonium salt) is an agonist of the P2X receptors, exhibiting 5-30-fold higher potency at the P2X7 receptor than ATP. BzATP (ammonium salt) inhibits rat and mouse P2X7 receptors with EC50 values being 3.6 and 285 μM, respectively. However, BzATP (ammonium salt) is not selective for the P2X7 receptor as it can potently activate other P2X receptors, but without the marked superiority to ATP as an agonist. Activation of P2X7 receptors contributes to the proliferation and migration of certain types of tumor, including human glioma, and is involved in sepsis-induced intestinal barrier dysfunction. In addition, BzATP (ammonium salt) can also be used as a photoaffinity probe for exploring adenine nucleotide binding to ATPases.?

References:

1.?Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends in Neurosciences, 2006, 29(5): 257-262.

2.?Young MT, Pelegrin P, Surprenant A. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology, 2007, 71(1): 92-100.

3.?Ji Z, Xie Y, Guan Y, et al. Involvement of P2X7 receptor in proliferation and migration of human glioma cells. BioMed Research International, 2018, 2018: 8591397.

4.?Wu X, Ren J, Chen G, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Scientific Reports, 2017, 7(1): 4364.

  1. Williams N, Coleman PS. Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. Journal of Biological Chemistry, 1982, 257(6): 2834-2841.

Product Citation

Chemical Properties

Physical AppearanceA white to off-white solid
StorageStore at -20°C
M.Wt816.59
Cas No.112898-15-4
FormulaC30H39N6O15P3
Solubility≤14 mg/ml in DMSO
Chemical Nametriethylamine rac-((2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-3-((4-benzoylbenzoyl)oxy)-4-hydroxytetrahydrofuran-2-yl)methyl triphosphate
SDFDownload SDF
Canonical SMILESO[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O.CCN(CC)CC
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[3]

Cell lines

U87 and U251 glioma cells

Reaction Conditions

10 ~ 1000?μM BzATP for 24 h incubation

Applications

BzATP at 10 μM was sufficient to induce the proliferation of glioma cell significantly, while the cell proliferation reached the peak with 100 μM BzATP. Also, the migration of U87 and U251 cells was significantly increased upon BzATP treatment.
Animal experiment:[4]

Animal models

Male 2-month-old C57BL/6 mice, 20 ~ 25 g

Dosage form

5?mg/kg

Intraperitoneal injection

Applications

BzATP significantly promoted P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction.

Note

The technical data provided above is for reference only.

References:

1. Anderson CM, Nedergaard M. Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons. Trends in Neurosciences, 2006, 29(5): 257-262.

2. Young MT, Pelegrin P, Surprenant A. Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Molecular Pharmacology, 2007, 71(1): 92-100.

3. Ji Z, Xie Y, Guan Y, et al. Involvement of P2X7 receptor in proliferation and migration of human glioma cells. BioMed Research International, 2018, 2018: 8591397.

4. Wu X, Ren J, Chen G, et al. Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption. Scientific Reports, 2017, 7(1): 4364.

5. Williams N, Coleman PS. Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-benzoyl)benzoyl adenosine 5'-triphosphate. Journal of Biological Chemistry, 1982, 257(6): 2834-2841.

Quality Control

Quality Control & MSDS

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Chemical structure

BzATP (ammonium salt)

Related Biological Data

BzATP (ammonium salt)