Cell lines

Dermatophyte fungi, yeasts, bacteria

Preparation method

The solubility of this compound in DMSO is ≥17.55mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0.03～0.25 μg/mL

Applications

Butenafine showed limited activity against Candida albicans and no activity against Malassezia furfur. Butenafine is not active against the gram-negative bacteria tested.

Animal models

Male Hartley strain guinea pigs

Dosage form

1%, once a day

Application

Butenafine has a good effect on dermatophyte, and the treatment effect is better than naftifine, tolnaftate, clotrimazole, and bifonazole. Using butenafine 24 or 48 hours before infection can help prevent experimental T. mentagrophytes infection.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1]. Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7. PubMed PMID: 12895182.

[2]. Arika T, Yokoo M, Hase T, Maeda T, Amemiya K, Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990 Nov;34(11):2250-3. PubMed PMID: 2073116; PubMed Central PMCID: PMC172031.