Gadolinium chloride is a CaSR agonist. The CaSR can activate the NLRP3 inflammasome by increasing intracellular Ca2+ and decreasing cellular cyclic AMP. Thus, CaSR agonists may serve as a useful tool for exploring NLRP3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. In addition, gadolinium chloride has been demonstrated to block TRPML channel currents, as well as other transient receptor potential (TRP) channels.?
References:
1.?Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012, 492(7427): 123-127.
2.?Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358.
3.?Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.
