成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Toggle Nav
Close
  • Menu
  • Setting

Gadolinium chloride

Catalog No.
B7706
A calcium-sensing receptor (CaSR) agonist
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$61.00
In stock
50mg
$55.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Gadolinium chloride is a CaSR agonist. The CaSR can activate the NLRP3 inflammasome by increasing intracellular Ca2+ and decreasing cellular cyclic AMP. Thus, CaSR agonists may serve as a useful tool for exploring NLRP3 inflammasome associated inflammatory diseases such as cryopyrin-associated periodic syndromes, gout and atherosclerosis. In addition, gadolinium chloride has been demonstrated to block TRPML channel currents, as well as other transient receptor potential (TRP) channels.?

References:

1.?Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012, 492(7427): 123-127.

2.?Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358.

3.?Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageDesiccate at RT
M.Wt263.61
Cas No.10138-52-0
FormulaGdCl3
Solubility≥11.04 mg/mL in DMSO; ≥2.03 mg/mL in EtOH with gentle warming and ultrasonic; ≥9.85 mg/mL in H2O
Chemical Namegadolinium(III) chloride
SDFDownload SDF
Canonical SMILESCl[Gd](Cl)Cl
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment:[3]

Cell lines

Skeletal muscle cells

Reaction Conditions

100 μM gadolinium chloride for 30min or 1 h incubation

Applications

Gadolinium chloride significantly reduced the cytotoxicity of palytoxin by blocking stretch-activated calcium channels, with a 30% increase in cell survival after up to 1 h of exposure to 1 nM palytoxin.

Note

The technical data provided above is for reference only.

References:

1. Lee GS, Subramanian N, Kim AI, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012, 492(7427): 123-127.

2. Nagata K, Zheng L, Madathany T, et al. The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(1): 353-358.

3. Del Favero G, Florio C, Codan B, et al. The stretch-activated channel blocker Gd3+ reduces palytoxin toxicity in primary cultures of skeletal muscle cells. Chemical Research in Toxicology, 2012, 25(9): 1912-1920.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Gadolinium chloride