Tenovin-3
Catalog No.
A8567
p53 activator
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Tenovin SAR Studies Aimed at Increasing Water Solubility
| ID |
 |
p53 Increasea | K40Ac Tubulin Increaseb | SirT2 Inhibitionc | |
|---|---|---|---|---|---|
| R1 | R2 | ||||
| Tenovin-1 | tBu | NHCOCH3 | + | + | + |
| Tenovin-2 | tBu | NHCOCH(CH3)2 | + | + | + |
| Tenovin-3 | tBu | NH2 | + | + | + |
| Tenovin-4 | N3 | NHCOCH3 | − | − | − |
| Tenovin-5 | tBu | NHCOPh | + | + | + |
| Tenovin-6 | tBu | NHCO(CH2)4NMe2.HCl | + | + | + |
- a Ability to increase p53 levels was determined in MCF-7 cells treated for 6 hr at 10 μM.
- b Ability to increase K40 Ac-tubulin levels was determined in H1299 cells treated
- c SirT2 inhibition assessed using a compound concentration of 10 or 30 μM depending on the compound's solubility in the assay buffer.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 327.44 |
| Cas No. | 1011301-27-1 |
| Formula | C18H21N3OS |
| Synonyms | Tenovin 3;Tenovin3 |
| Solubility | insoluble in H2O; ≥14.45 mg/mL in DMSO; ≥2.88 mg/mL in EtOH with gentle warming |
| Chemical Name | N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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