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- Pentamidine
Pentamidine
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 340.42 |
| Cas No. | 100-33-4 |
| Formula | C19H24N4O2 |
| Solubility | insoluble in EtOH; ≥13.5 mg/mL in DMSO; ≥78 mg/mL in H2O |
| Chemical Name | 4-[5-(4-carbamimidoylphenoxy)pentoxy]benzenecarboximidamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Melanoma (WM9), prostate carcinoma (DU145 and C4–2), ovarian carcinoma (Hey), colon carcinoma (WM480), and lung carcinoma (A549) |
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Preparation method |
The solubility of this compound in DMSO is ≥13.5mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
10 μg/ml |
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Applications |
The growth of all six of the cell lines in culture was inhibited by pentamidine in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 μg/ml. These results demonstrated an in vitro growth-inhibitory activity of pentamidine against different human cancer cell lines that expressed the endogenous PRL phosphatases. |
| Animal experiment [1]: | |
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Animal models |
Athymic nude mouse model |
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Dosage form |
6–10 mg/kg (i.m.), once every two days |
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Application |
At the 16th week of the study, the tumor size of the experimental mice treated with Pentamidine was similar to that at the beginning of the treatment, while the tumors of the control mice grew so fast that humanitarian sacrifices were required at 4 weeks. At the end of the study period, there were no significant histological changes in the internal organs (heart, kidney, liver, lung, and spleen) of Pentamidine-treated mice. The tumors of these mice were evaluated and found that necrosis accounted for more than 50% of the total tumors, while the tumors of untreated control mice did not. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Pathak MK, Dhawan D, Lindner DJ, Borden EC, Farver C, Yi T. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PubMed PMID: 12516958. |
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Quality Control & MSDS
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Chemical structure
