[ CAS No. 99-76-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

2D 3D

Structure of 99-76-3 * Storage: {[proInfo.prStorage]}

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}	Login		Inquiry

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 99-76-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 99-76-3 ]

SDS Specification

Alternatived Products of [ 99-76-3 ]

Product Details of [ 99-76-3 ]

CAS No. :	99-76-3	MDL No. :	MFCD00002352
Formula :	C₈H₈O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	LXCFILQKKLGQFO-UHFFFAOYSA-N
M.W :	152.15	Pubchem ID :	7456
Synonyms :	Methyl 4-hydroxybenzoate;Methyl p-hydroxybenzoate;Septos;Maseptol;Methyl parahydroxybenzoate;Nipagin	Chemical Name :	Methyl 4-hydroxybenzoate

Calculated chemistry of [ 99-76-3 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.12
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	39.74
TPSA :	46.53 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.84 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.63
Log Po/w (XLOGP3) :	1.96
Log Po/w (WLOGP) :	1.18
Log Po/w (MLOGP) :	1.32
Log Po/w (SILICOS-IT) :	1.21
Consensus Log Po/w :	1.46

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.29
Solubility :	0.781 mg/ml ; 0.00513 mol/l
Class :	Soluble
Log S (Ali) :	-2.56
Solubility :	0.417 mg/ml ; 0.00274 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-1.88
Solubility :	2.0 mg/ml ; 0.0132 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.02

Safety of [ 99-76-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P501-P261-P273-P272-P264-P280-P302+P352-P312-P362+P364-P333+P313	UN#:	N/A
Hazard Statements:	H303-H315-H317-H412	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 99-76-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 99-76-3 ]
Downstream synthetic route of [ 99-76-3 ]

[ 99-76-3 ] Synthesis Path-Upstream 1~2

1
[ 99-76-3 ]
[ 25978-74-9 ]

Reference： [1] Journal of Materials Chemistry C, 2016, vol. 4, # 19, p. 4269 - 4277
[2] Patent: US2012/184587, 2012, A1,
[3] Patent: WO2009/158393, 2009, A1,

2
[ 99-76-3 ]
[ 499770-67-1 ]

Reference： [1] Journal of Organic Chemistry, 2013, vol. 78, # 7, p. 2965 - 2983

[ 99-76-3 ] Synthesis Path-Downstream 1~16

1
[ 99-76-3 ]
[ 3337-66-4 ]

Yield	Reaction Conditions	Operation in experiment
99%	With sodium percarbonate; acetic acid; potassium iodide; In water; for 2.5h;	General procedure: Potassium iodide (2.1 equiv) was added with stirring to 50% (v/v) aq. AcOH (1.0 M) containing a phenol derivative S5, and sodium percarbonate (SPC) (3.8 equiv) was slowly added over 30 min. The stirring was continued for 2.0 h at 50 oC under a reflux condenser. After cooling, the reaction mixture was slowly poured into a vigorously stirred biphasic mixtures made of CH2Cl2 and saturated aqueous Na2SO3. Separated aqueous layer was extracted twice with CH2Cl2. The combined organic layer was washed with saturated aqueous NaCl. The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by column chromatography to provide 23.
99%	With acetic acid; periodic acid; potassium iodide; In water; at 60℃;	30.4 g of methyl p-hydroxybenzoate was added to a 2 L single-necked flask, 1 L of acetic acid, 500 ml of water, 42.8 g of periodic acid and 66.4 g of potassium iodide were added and reacted at 60 C overnight.The TLC plate showed complete reaction, where the TLC developing agent was PE: EA = 5: 1.The reaction solution was cooled to room temperature, added to 2 L of water, filtered, and the solid was dried with an infrared lamp to obtain 80 g of a yellow solid, that is, a compound having a structure represented by the formula M2-1 in a yield of 99%.
98.8%		10 g (65.7 mmol) of p-methoxybenzoate , 80 ml of methanol were added thereto, stirred and dissolved, and 11.3 g of sodium acetate and 7 g of water were added thereto, stirred and dissolved, and 30 g of iodine (118.3 mmo 1) was added thereto, and the temperature was raised to 70 C. After reacting for 2 hours, a sodium hydroxide solution (sodium hydroxide 5.5 g (137.5 mmol) and water 200 ml) was added, and the reaction was kept at 70 C for 2 hours, and the temperature was slowly lowered to room temperature, and 10 g of a 25% sodium hydrogen sulfite solution was added dropwise thereto. The color of the liquid was removed, and the crystals were further stirred for 1 hour, filtered, and the wet product was dried by hot air at 50 for 8 hours to obtain 26.2 g of a white crystalline powder, yield 98.8%.

86.7%

To methanol (150 mL)Was added methyl p-hydroxybenzoate (10 g, 65.7 mmol)Sodium acetate hydrate (18.78 g, 138 mmol) andIodine (35 g, 137.9 mmol)The resulting mixture was stirred under reflux for 1.5 hours.A solution of sodium hydroxide (5.52 g, 138 mmol)Of water (200 mL)Then reflux for 2.5 hours.Cool to room temperature and add dilute sulfurSodium hydrogen acid solution to the color faded. The filter cake was washed with a small amount of water and then dissolved with ethyl acetate (200 mL), anhydrous sulfuric acidSodium dry. The solvent was evaporated under reduced pressure and the resulting product was recrystallized from petroleum ether / ethyl acetate,4-hydroxy-3,5-diiodobenzoate (11) (23 g). The yield was 86.7%.

Reference： [1]Angewandte Chemie - International Edition,2010,vol. 49,p. 5563 - 5566
[2]Tetrahedron,2013,vol. 69,p. 4338 - 4352
[3]Patent: CN106632180,2017,A .Location in patent: Paragraph 0054-0058
[4]Patent: CN109988132,2019,A .Location in patent: Paragraph 0077-0079
[5]Patent: CN106478619,2017,A .Location in patent: Paragraph 0097; 0098
[6]Chemistry Letters,1987,p. 2109 - 2112
[7]Biochemical Journal,1951,vol. 48,p. 188,189
[8]Journal of Organic Chemistry,2013,vol. 78,p. 2965 - 2983

2
[ 81765-97-1 ]
[ 99-76-3 ]
p-(2-Methyl-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidin-4-yloxy)benzoesaeuremethylester [ No CAS ]

Reference： [1]Pharmazie,1993,vol. 48,p. 585 - 587

3
[ 99-76-3 ]
[ 403-01-0 ]

Reference： [1]Journal of the American Chemical Society,1990,vol. 112,p. 8563 - 8575
[2]Journal of Fluorine Chemistry,2003,vol. 120,p. 173 - 183

4
[ 99-76-3 ]
[ 403-01-0 ]
[ 170572-47-1 ]

Reference： [1]Journal of Fluorine Chemistry,2000,vol. 102,p. 169 - 173

5
[ 1700-31-8 ]
[ 99-76-3 ]
[ 814920-59-7 ]

Reference： [1]Journal of Agricultural and Food Chemistry,2000,vol. 48,p. 2547 - 2555

6
[ 107-30-2 ]
[ 99-76-3 ]
[ 854422-96-1 ]
[ 3337-66-4 ]
[ 139884-19-8 ]

Reference： [1]Synthesis,2005,p. 1019 - 1027

7
[ 99-76-3 ]
[ 3337-66-4 ]
[ 15126-06-4 ]

Reference： [1]RSC Advances,2019,vol. 9,p. 19549 - 19559
[2]Synthesis,2005,p. 1019 - 1027

8
[ 19748-66-4 ]
[ 99-76-3 ]
[ 193964-20-4 ]

Reference： [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 649 - 663

9
[ 99-76-3 ]
[ 84449-80-9 ]

Reference： [1]European Journal of Medicinal Chemistry,2007,vol. 42,p. 71 - 80
[2]Bioorganic and Medicinal Chemistry,2013,vol. 21,p. 7250 - 7256

10
[ 99-76-3 ]
[ 3337-62-0 ]

Reference： [1]Journal of the Society of Chemical Industry,1945,vol. 64,p. 212,214

11
[ 439134-78-8 ]
[ 99-76-3 ]
[ 866531-04-6 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In acetonitrile; at 60℃; for 5h;	Example 6; Intermediate: 4-14-Methyl-2-(4-trifluoromethvl-phenvl)-thiazol-5-ylmethoxyl-benzoic acid methyl ester; To a mixture of 4-hydroxy-benzoic acid methyl ester (152 mg, 1 mmol) and potassium carbonate (152 mg, 1.1 mmol) add acetonitrile (4 mL). To this mixture add 5-bromomethyl-4- methyl-2- (4-trifluoromethyl-phenyl)-thiazole (Example 4, 314 mg, 1 mmol). Warm the resulting reaction mixture to 60°C, and stir at this temperature for 5 hrs. Cool the mixture to room temperature, dilute with ethyl acetate, wash with water, then brine, dry over MgS04, filter and concentrate to give the title compound as a white solid (364 mg). MS (ESI) m/z 408 (M+H) ; H1 NMR (CDCl3) 8 2.53 (s, 3H), 3.90 (s, 3H), 4.52 (s, 2H), 7.00 (d, J = 9Hz, 2H), 7.68 (d, J = 8Hz, 2H), 8.02 (m, 4H).

Reference： [1]Patent: WO2005/97762,2005,A2 .Location in patent: Page/Page column 44-45

12
[ 19748-66-4 ]
[ 99-76-3 ]
[ 1972-28-7 ]
[ 193964-20-4 ]

Yield	Reaction Conditions	Operation in experiment
	With triphenylphosphine;SiO2; In methanol; dichloromethane;	Part B. Methyl 4-[3-(1-Pyrrolidinyl)propoxy]benzoate STR40 A solution of 6.25 g (23.8 mmol) of triphenylphosphine, 3.30 g (21.7 mmol) of methyl 4-hydroxybenzoate, and 2.80 g (21.7 mmol) of 1-(3-hydroxypropyl)pyrrolidine in 100 mL of CH2 Cl2 was treated with 3.80 mL (24.1 mmol) of diethyl azodicarboxylate in a dropwise manner. The reaction was stirred at ambient temperature for 16 h and was quenched by the addition of 20 mL of brine. The two layers were separated, and the organic layer was dried over K2 CO3 and concentrated to give 6.10 g of an oily solid which was purified by flash chromatography (SiO2; 0-5percent MeOH in CH2 Cl2) to afford 2.46 g (9.34 mmol; 43percent) of the desired product. FDMS 263 (M+; 100); HRMS Calcd for C15 H21 NO3: 264.1600. Found: 264.1609.

Reference： [1]Patent: US6025382,2000,A

13
[ 93148-78-8 ]
[ 2008-75-5 ]
[ 99-76-3 ]
[ 84449-80-9 ]

Yield	Reaction Conditions	Operation in experiment
87.7%	With potassium carbonate; In Isopropyl acetate; water;	EXAMPLE 4 Preparation of 4-(2-piperidinoethoxy)benzoic acid hydrochloride To a 250 mL 3 neck flask equipped with mechanical stirring, condenser, and heating apparatus consisting of a RTD probe hooked via a temperature controller to a heating mantle and under nitrogen atmosphere, the following were added: 7.61 g methyl 4-hydroxybenzoate, 11.05 g beta-chloroethylpiperidine hydrochloride, 16.59 g powdered potassium carbonate, and 60 mL isopropyl acetate. The mixture was heated slowly to 80° C. After 5 hours, high performance liquid chromatography showed reaction to be 90percent complete. After being left overnight at 80° C., reaction was complete. The mixture was then cooled to ambient temperature, after which 60 mL deionized water was added. The mixture was stirred until all solids dissolved. The aqueous layer was separated and discarded. The organic layer was extracted 3 times with 20 mL 4N hydrochloride. The combined aliquots, containing 4-(2-piperidinoethoxy)benzoic acid, ethyl ester, were heated at reflux (92° C., 30 minutes required to reach reflux). After 7.5 hours at reflux, the mixture was then distilled to remove approximately 10 mL water and cooled in an ice bath for 15 minutes. The resulting crystalline 4-(2-piperidinoethoxy)benzoic acid, hydrochloride was removed by filtration and rinsed with acetone and dried. Yield=12.53 g of product (87.7percent of theoretical).

Reference： [1]Patent: US5631369,1997,A

14
[ 2008-75-5 ]
[ 99-76-3 ]
[ 84449-80-9 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In water; ethyl acetate;	EXAMPLE 9 Preparatlon of 4-(2-piperidinoethoxy)benzoic acid hydrochloride To a 250 mL 3 neck flask with mechanical stirring and condenser, and a heating apparatus consisting of an RTD probe in the flask hooked via a temperature controller to a heating mantle and under nitrogen atmosphere, the following was added: 7.61 g of methyl 4-hydroxybenzoate, 11.05 g of beta-chloroethylpiperidine hydrochloride, 16.59 g of powdered potassium carbonate and 60 mL of ethyl acetate. The mixture was heated slowly to reflux. After overnight reflux, the mixture was cooled to ambient temperature, after which 60 mL of deionized water was added. The aqueous layer was separated and discarded. The organic layer was extracted with 4N hydrochloride (3 aliquots of 20 mL). The combined acid extracts were heated to reflux. After 1 hour at reflux, HPLC indicated the saponification to be 60percent complete. After 4 hours, the reaction was near 100percent complete. The mixture was cooled to 0° C.-5° C. and stirred. The resulting crystals were filtered, rinsed with acetone and dried.

Reference： [1]Patent: US5631369,1997,A

15
[ 2008-75-5 ]
[ 99-76-3 ]
[ 89407-97-6 ]
[ 84449-80-9 ]

Yield	Reaction Conditions	Operation in experiment
95.3%	With potassium carbonate; In Isopropyl acetate; water;	a. To a 250 mL 3 neck flask, with mechanical stirring, condenser, and RTD probe were added the following under nitrogen atmosphere: 0.05 mol methyl 4-hydroxybenzoate, 0.06 mol beta-chloroethylpiperidine hydrochloride, 16.59 grams of potassium carbonate, and 60 mL of isopropyl acetate. The mixture was heated at 75° C.-80° C. for 20 hours, at which time all the methyl 4-hydroxybenzoate was consumed. 60 mL of water was then added to dissolve the potassium carbonate. The organic and aqueous phases were then Separated and the aqueous layer discarded. The organic layer was washed with a second 60 mL aliquot of water; the layers were separated and the aqueous layer discarded. The reaction product, 4-(2-piperidinoethoxy)benzoic acid, methyl ester, was then extracted into 25 mL 8N hydrochloric acid. The aqueous phase was separated and the organic phase discarded. The aqueous phase was refluxed in a 50 mL round bottomed flask with magnetic stirring and condenser for 48 hours. The mixture was then cooled to 0° C.-5° C. and the crystals removed by filtration. The crystals were rinsed with acetone and dried overnight in 50° C. vacuum oven. 13.63 g of 4-(2-piperidinoethoxy)benzoic acid hydrochloride were recovered, which is 95.3percent of the theoretical yield.

Reference： [1]Patent: US5631369,1997,A

16
[ 1480-65-5 ]
[ 99-76-3 ]
methyl 4-((5-chloropyridin-2-yl)oxy)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
9 g	With caesium carbonate; In N,N-dimethyl-formamide; at 110℃; for 12h;	[0064] Methyl 4-hydroxybenzoate (6.5 g, 49 mmol), <strong>[1480-65-5]5-chloro-2-fluoropyridine</strong> (5.0 g, 33 mmol) and cesium carbonate(20 g, 65 mmol) were dissolved in N,N-dimethyl foramide (50 mL). The reaction solution was refluxed at 110 °C for 12hours, and the completion of reaction was monitored by thin layer chromatography (petroleum ether:ethyl acetate = 5:1),the solvent was rotary dried. The crude compound was partitioned between ethyl acetate (250 mL) and water (250 mL).The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated under a reduced pressure. Thecrude compound was purified and separated by column chromatography to yield the product methyl 4-((5-chloropyridin-2-yl)oxy)benzoate (9.0 g, 93percent).MS: m/z 264.2 [M+1]

Reference： [1]Patent: EP3459940,2019,A1 .Location in patent: Paragraph 0064; 0094

Recommend Products

Same Skeleton Products

Related Products

Isomers

Technical Information

? Acidity of Phenols ? Chan-Lam Coupling Reaction ? Electrophilic Substitution of the Phenol Aromatic Ring ? Etherification Reaction of Phenolic Hydroxyl Group ? Halogenation of Phenols ? Oxidation of Phenols ? Pechmann Coumarin Synthesis ? Preparation of Aldehydes and Ketones ? Reimer-Tiemann Reaction

Historical Records

Similar Product of
[ 99-76-3 ]

A1230215[ 1581694-95-2 ]

Methyl 4-hydroxybenzoate-(ring-13C6)

Reason: Stable Isotope

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

[ CAS No. 99-76-3 ] {[proInfo.proName]}

Quality Control of [ 99-76-3 ]

Related Doc. of [ 99-76-3 ]

Product Details of [ 99-76-3 ]

Calculated chemistry of [ 99-76-3 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 99-76-3 ]

Application In Synthesis of [ 99-76-3 ]

[ 99-76-3 ] Synthesis Path-Upstream 1~2

[ 99-76-3 ] Synthesis Path-Downstream 1~16

Technical Information

Similar Product of [ 99-76-3 ]

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Similar Product of
[ 99-76-3 ]