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Yuan, Gengyang ; Dhaynaut, Maeva ; Lan, Yu , et al. J. Med. Chem.,2022,65(3):2593-2609. DOI: 10.1021/acs.jmedchem.1c02004 PubMed ID: 35089713
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Abstract: Metabotropic glutamate receptor 2 (mGluR2) is a therapeutic target for several neuropsychiatric disorders. An mGluR2 function in etiology could be unveiled by positron emission tomography (PET). In this regard, 5-(2-fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide ([11C]13, [11C]mG2N001), a potent negative allosteric modulator (NAM), was developed to support this endeavor. [11C]13 was synthesized via the O-[11C]methylation of phenol 24 with a high molar activity of 212 ± 76 GBq/μmol (n = 5) and excellent radiochemical purity (>99%). PET imaging of [11C]13 in rats demonstrated its superior brain heterogeneity and reduced accumulation with pretreatment of mGluR2 NAMs, VU6001966 (9) and MNI-137 (26), the extent of which revealed a time-dependent drug effect of the blocking agents. In a nonhuman primate, [11C]13 selectively accumulated in mGluR2-rich regions and resulted in high-contrast brain images. Therefore, [11C]13 is a potential candidate for translational PET imaging of the mGluR2 function.
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CAS No. : | 98-96-4 | MDL No. : | MFCD00006132 |
Formula : | C5H5N3O | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | IPEHBUMCGVEMRF-UHFFFAOYSA-N |
M.W : | 123.11 | Pubchem ID : | 1046 |
Synonyms : |
Pyrazinoic Acid Amide; Pyrazinecarboxamide; Pyrazine-2-carboxamide
|
Chemical Name : | Pyrazine-2-carboxamide |
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | |
Hazard Statements: | H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.