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CAS No. : | 941714-57-4 | MDL No. : | MFCD23106341 |
Formula : | C6H6BrNO2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | RWYUPXPKZMQREC-UHFFFAOYSA-N |
M.W : | 204.02 | Pubchem ID : | 44189804 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With sodium methylate In methanol at 20℃; for 4 h; | a) Methyl 3-bromo-1 H-pyrrole-2-carboxylateTo a solution of methyl 3-bromo-1 -(phenylsulfonyl)-1 H-pyrrole-2-carboxylate2 (6.59 g, 19.2 mmol) in 132 mL of methanol was added MeONa (1 .55 g, 28.7 mmol) and the mixture was stirred at room temperature during 4 h. The solvent was evaporated and the residue was partitioned between ammonium chloride saturated aqueous solution and ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulphate, filtered and evaporated under vacuum. The product was purified by flash chromatography (0percent to 30percent hexane/AcOEt) to yield 3.32 g (85percent) of the title compound.LRMS (m/z): 203, 205 (M+1 )+. |
85% | With sodium methylate In methanol at 0 - 20℃; for 4 h; Inert atmosphere | Methyl 3-bromo-1 -(phenylsulfonyl)-1 H-pyrrole-2-carboxylate (6.59 g, 19.15 mmol) was dissolved in 132 mL anhydrous methanol under nitrogen atmosphere and it was cooled at 0°C. Sodium methoxide (1 .55 g, 28.69 mmol) was added and the reaction mixture was stirred at room temperature for 4h. The reaction was poured into a saturated ammonium chloride solution and extracted twice with ethyl acetate. The organics were combined and washed with water, brine, dried over sodium sulphate, filtered and evaporated under reduced pressure. The crude was purified using SP1?Purification System (0percent to 30percent, hexane-ethyl acetate) to obtain 3.32 g (85percent yield) of the title compound as a white solid.LRMS (m/z): 204, 206 (M+1 )+. |
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