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CAS No. : | 941294-57-1 | MDL No. : | MFCD09801049 |
Formula : | C6H5BrIN | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | CWTODKHZZURTJS-UHFFFAOYSA-N |
M.W : | 297.92 | Pubchem ID : | 26369928 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
23% | With potassium fluoride; copper(l) iodide; In 1-methyl-pyrrolidin-2-one; at 60℃;Inert atmosphere; | To a suspension of 5-bromo-2-iodo-4-methylpyridine(1g, 3.36 mmol) in NMP (6mL) with an inert atmosphere of argon, KF (0.585 g, 10.07 mmol), Cul (1.92 g, 10.08 mmol) and CF3SiMe3 (2.49 mL, 15.07 mmol) were added. The resulting solution was stirred overnight at 60C. After cooling, the mixture was poured into 12% aqueous ammonia, and then extracted with Et2O. The organic solutions were combined, dried over MgSO4, filtered and concentrated. Purification of the crude residue by normal phase chromatography (0% to 100%, hexane - diethyl ether) afforded the desired product (23% yield) as a yellow oil. |
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