成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 92-85-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 92-85-3
Chemical Structure| 92-85-3
Structure of 92-85-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 92-85-3 ]

Related Doc. of [ 92-85-3 ]

Alternatived Products of [ 92-85-3 ]
Product Citations

Product Citations

Min Ji Kim ; Diana J. Wang ; Karina Targos , et al. DOI: PubMed ID:

Abstract: Cyclopropanes are desirable structural motifs with valuable applications in drug discovery and beyond. Established alkene cyclopropanation methods give rise to cyclopropanes with a limited array of substituents, are difficult to scale, or both. Herein, we disclose a new cyclopropane synthesis through the formal coupling of abundant carbon pronucleophiles and unactivated alkenes. This strategy exploits dicationic adducts derived from electrolysis of thianthrene in the presence of alkene substrates. We find that these dielectrophiles undergo cyclopropanation with methylene pronucleophiles via alkenyl thianthrenium intermediates. This protocol is scalable, proceeds with high diastereoselectivity, and tolerates diverse functional groups on both the alkene and pronucleophile coupling partners. To validate the utility of this new procedure, we prepared an array of substituted analogs of an established cyclopropane that is en route to multiple pharmaceuticals.

Purchased from AmBeed:

Product Details of [ 92-85-3 ]

CAS No. :92-85-3 MDL No. :MFCD00005065
Formula : C12H8S2 Boiling Point : -
Linear Structure Formula :- InChI Key :GVIJJXMXTUZIOD-UHFFFAOYSA-N
M.W : 216.32 Pubchem ID :7109
Synonyms :

Calculated chemistry of [ 92-85-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 14
Num. arom. heavy atoms : 12
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 0.0
Num. H-bond donors : 0.0
Molar Refractivity : 61.13
TPSA : 50.6 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : Yes
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -4.45 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.66
Log Po/w (XLOGP3) : 4.47
Log Po/w (WLOGP) : 4.3
Log Po/w (MLOGP) : 4.56
Log Po/w (SILICOS-IT) : 4.14
Consensus Log Po/w : 4.03

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -4.63
Solubility : 0.00505 mg/ml ; 0.0000234 mol/l
Class : Moderately soluble
Log S (Ali) : -5.25
Solubility : 0.00121 mg/ml ; 0.00000559 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -5.13
Solubility : 0.00159 mg/ml ; 0.00000733 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 2.66

Safety of [ 92-85-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Parent Nucleus of
[ 92-85-3 ]

Other Aromatic Heterocycles

Chemical Structure| 158962-92-6

[ 158962-92-6 ]

2,3-Dihydrothieno[3,4-b][1,4]dithiine

Similarity: 0.76

Chemical Structure| 40985-58-8

[ 40985-58-8 ]

Thieno[3,2-b]thiophene-2-carbonitrile

Similarity: 0.67

Chemical Structure| 248-70-4

[ 248-70-4 ]

Benzo[b]benzo[4,5]thieno[2,3-d]thiophene

Similarity: 0.62

Chemical Structure| 25121-87-3

[ 25121-87-3 ]

2,5-Dibromothieno[3,2-b]thiophene

Similarity: 0.56

Chemical Structure| 365547-20-2

[ 365547-20-2 ]

4,4-Bis(2-ethylhexyl)-4H-cyclopenta[1,2-b:5,4-b']dithiophene

Similarity: 0.55

; ;