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Chemical Structure| 905854-02-6 Chemical Structure| 905854-02-6

Structure of Tivantinib
CAS No.: 905854-02-6

Chemical Structure| 905854-02-6

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CAS No.: 905854-02-6

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Tivantinib is an non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM with little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4.

Synonyms: ARQ 197; (3R,4R)-ARQ 198

4.5 *For Research Use Only !

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Product Details of Tivantinib

CAS No. :905854-02-6
Formula : C23H19N3O2
M.W : 369.42
SMILES Code : O=C([C@@H](C1=CN2CCCC3=C2C1=CC=C3)[C@@H]4C5=CNC6=C5C=CC=C6)NC4=O
Synonyms :
ARQ 197; (3R,4R)-ARQ 198
MDL No. :MFCD11977597
InChI Key :UCEQXRCJXIVODC-PMACEKPBSA-N
Pubchem ID :11494412

Safety of Tivantinib

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360-H373
Precautionary Statements:P201-P260-P280-P308+P313
Class:6.1
UN#:2811
Packing Group:Ⅲ

Related Pathways of Tivantinib

epigenetics
RTK

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Huh7 cells 5 μM 6-24 hours To determine the effect of Tivantinib on MT-1G mRNA expression, results showed that Tivantinib did not affect MT-1G mRNA expression PMC4956496
MSKLeuk1 0.0–0.04 μM To evaluate the cytotoxicity of ARQ197 on MSKLeuk1 cells, results showed that ARQ197 had a lower IC50 for MSKLeuk1 cells, indicating higher sensitivity. PMC5946820
MSKLeuk1s 0.0–0.04 μM To evaluate the cytotoxicity of ARQ197 on MSKLeuk1s cells, results showed that ARQ197 had a lower IC50 for MSKLeuk1s cells, indicating higher sensitivity. PMC5946820
HaCaT 0.0–0.04 μM To evaluate the cytotoxicity of ARQ197 on HaCaT cells, results showed that ARQ197 had a lower IC50 for HaCaT cells, indicating higher sensitivity. PMC5946820
HOK-16B 0.0–0.04 μM To evaluate the cytotoxicity of ARQ197 on HOK-16B cells, results showed that ARQ197 had a lower IC50 for HOK-16B cells, indicating higher sensitivity. PMC5946820
SW1736 0.1–10 μM 24 hours Tivantinib induced G2/M cell cycle arrest and apoptosis PMC3947168
T2 0.1–10 μM 24 hours Tivantinib induced G2/M cell cycle arrest and apoptosis PMC3947168
TL3 0.1–10 μM 24 hours Tivantinib induced G2/M cell cycle arrest and apoptosis PMC3947168
U266 1 μM 48 hours Tivantinib induced apoptosis and inhibited cell growth PMC4372650
μM.1S 1 μM 48 hours Tivantinib induced apoptosis and inhibited cell growth PMC4372650
OPM-2 1 μM 48 hours Tivantinib induced apoptosis and inhibited cell growth PMC4372650
RPMI-8226 1 μM 48 hours Tivantinib induced apoptosis and inhibited cell growth PMC4372650
Panc1 cells 1 μM or 2.5 μM 48 hours To assess cell viability, results showed that Tivantinib combined with Fendiline significantly inhibited cell growth PMC6567171
MiaPaCa2 cells 1 μM or 2.5 μM 48 hours To assess cell viability, results showed that Tivantinib combined with Fendiline significantly inhibited cell growth PMC6567171
CD18/HPAF cells 1 μM or 2.5 μM 48 hours To assess cell viability, results showed that Tivantinib combined with Fendiline significantly inhibited cell growth PMC6567171

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Immunodeficient mice (nonobese diabetic and severe combined immunodeficiency gamma mice) Oral 3 mg/kg body weight 5 days/week for 4 weeks In immunodeficient mice, Tivantinib reduced tumor progression of HCA-1 cells, but failed to inhibit tumor growth in immunocompetent mice. PMC6904924
Mice 4-NQO-induced oral tumor model Oral 15 mg/kg At the time of surgery and again 24 hours later To evaluate the efficacy of crizotinib in preventing oral cancer in the 4-NQO model, results showed that crizotinib significantly reduced the incidence of squamous cell carcinoma. PMC5946820
mice ligature-induced periodontitis mouse model oral 50 mg/kg Twice daily for 17 days Tivantinib was used to inhibit the HGF/Met signaling pathway to study its effect on macrophage polarization in periodontitis. Results showed that Tivantinib significantly reduced the number of Arg1+ cells, indicating that inhibition of the HGF-Met signaling interaction in macrophages blocks their polarization. PMC9576272
mice myeloma xenograft model oral 5 mg/kg 5 days/week for 2 weeks Tivantinib showed antitumor activity in the mouse model PMC4372650

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00557609 Renal Cell Carcinoma (RCC)|Alv... More >>eolar Soft Part Sarcoma (ASPS)|Clear Cell Sarcoma (CCS) Less << PHASE2 COMPLETED 2025-02-11 San Francisco, California, 941... More >>43, United States|Santa Monica, California, 90404, United States|Miami, Florida, 33136, United States|Boston, Massachusetts, 02115, United States|Cincinnati, Ohio, 45229, United States|Dallas, Texas, 75201, United States|Houston, Texas, 77030, United States|Toronto, Ontario, M5G 2M9, Canada|London, SW3 6JJ, United Kingdom Less <<
NCT01696955 Head and Neck Squamous Cell Ca... More >>rcinoma Recurrent Head and Neck Carcinoma Less << Phase 2 Active, not recruiting - United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, California City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Iowa University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Metro Minnesota Community Oncology Research Consortium Saint Louis Park, Minnesota, United States, 55416 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01468922 Sarcoma Stoma... More >>ch Neoplasms Neoplasms Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT02029157 Liver Cancer Phase 3 Completed - Japan ... More >> Cancer Centers in Japan Tokyo, Japan Less <<
NCT00558207 Pancreatic Neoplasms Phase 2 Completed - Poland ... More >> Oddzial Kliniczny Kliniki Onkologii Szpital Uniwersytecki w Krakowie Krakow, Poland, 31-531 Oddzial Chemioterapii, Wojewodzki Szpital Specjalistyczny Krakow, Poland, 31-826 Oddzia? Onkologii Klinicznej, Regionalny Szpital Specjalistyczny "Latawiec" Swidnica, Poland, 58-100 Oddzia? Onkologii Klinicznej SP ZOZ Wojewódzki Szpital Zespolony im. L. Rydygiera Torun, Poland, 53/59 Klinika Onkologii WIM Warszawa Warszawa, Poland, 00-909 Oddzia? Chemioterapii Dolno?l?skie Centrum Onkologii Wroclaw, Poland, 53-413 Less <<
NCT01070290 Gastric Cancer Phase 2 Withdrawn - -
NCT00302172 Cancer|Tumor PHASE1 COMPLETED - Premiere Oncology, Santa Monic... More >>a, California, 90404, United States|The Cleveland Clinic, Cleveland, Ohio, 44195, United States|Mary Crowley Medical Research Center, Dallas, Texas, 75246, United States Less <<
NCT00612703 Cancer PHASE1 COMPLETED - San Diego Pacific Oncology and... More >> Hematology Associates Inc., Encinitas, California, 92024, United States|Premiere Oncology, Santa Monica, California, 90404, United States Less <<
NCT00658554 Healthy PHASE1 COMPLETED 2025-06-08 Covance Clinical Research Unit... More >>, Inc., Evansville, Indiana, 47714, United States Less <<
NCT01688973 Recurrent Renal Cell Carcinoma... More >> Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Type 1 Papillary Renal Cell Carcinoma Type 2 Papillary Renal Cell Carcinoma Less << Phase 2 Completed - -
NCT00609921 Cancer Phase 1 Completed - -
NCT00777309 Non Small Cell Lung Cancer Phase 2 Completed - -
NCT01654965 Adult Solid Neoplasm Phase 1 Completed - United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT00874042 Advanced Solid Tumors Phase 1 Completed - United States, Georgia ... More >> Atlanta, Georgia, United States, 30341 United States, Oklahoma Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Nashville, Tennessee, United States, 37203 United States, Texas Houston, Texas, United States, 77024 Less <<
NCT00802555 Cirrhosis|Hepatocellular Carci... More >>noma Less << PHASE1 COMPLETED 2025-12-11 Dallas, Texas, 75246, United S... More >>tates|Houston, Texas, 77024, United States|Bologna, 15-40138, Italy|Milano, 20089, Italy|Barcelona, 08036, Spain Less <<
NCT01580735 Non-small-cell Lung Cancer PHASE2 COMPLETED 2025-04-15 Arakawa-ku, Tokyo, Japan
NCT01377376 Non-small-cell Lung Cancer Phase 3 Terminated - Japan ... More >> Osaka, Japan Less <<
NCT00827177 Advanced Solid Tumors Phase 1 Completed - United States, Massachusetts ... More >> Boston, Massachusetts, United States, 02111 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 United States, Tennessee Nashville, Tennessee, United States, 37232 Italy Rozzano, Italy, 20089 Less <<
NCT01519414 - Completed - -
NCT01075048 Metastatic Colorectal Cancer Phase 1 Phase 2 Completed - -
NCT01178411 Advanced Solid Tumors Phase 1 Phase 2 Active, not recruiting February 2019 United States, California ... More >> Los Angeles, California, United States, 90033 Santa Monica, California, United States, 90404 United States, Connecticut Torrington, Connecticut, United States, 06790 United States, Florida Miami, Florida, United States, 33136 United States, Georgia Atlanta, Georgia, United States, 30341 United States, Massachusetts Boston, Massachusetts, United States, 02114 United States, North Carolina Durham, North Carolina, United States, 27705 United States, Tennessee Nashville, Tennessee, United States, 37203 Nashville, Tennessee, United States, 37232 United States, Texas Dallas, Texas, United States, 75390 Houston, Texas, United States, 77030 San Antonio, Texas, United States, 78229 Germany Munich, Germany, 82131 Italy Milan, Italy, 20089 Russian Federation Moscow, Russian Federation, 123367 St. Petersburg, Russian Federation, 197089 Less <<
NCT00612209 Cancer, Advanced Solid Tumors PHASE1 COMPLETED 2025-02-10 The Royal Marsden Hospital, Su... More >>tton, Surrey, SM25PT, United Kingdom Less <<
NCT01152645 Gastric Cancer PHASE2 COMPLETED 2025-08-11 Nagoya, Japan|Seoul, Korea, Re... More >>public of Less <<
NCT00651638 Healthy Phase 1 Completed - United States, Indiana ... More >> Covance Clinical Research Unit, Inc. Evansville, Indiana, United States, 47714 Less <<
NCT01575522 - Completed - -
NCT01575522 Estrogen Receptor Negative ... More >> HER2/Neu Negative Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IV Breast Cancer Triple-Negative Breast Carcinoma Less << Phase 2 Completed - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Faulkner Hospital Boston, Massachusetts, United States, 02130 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Less <<
NCT01519414 Hormone-Resistant Prostate Can... More >>cer Prostate Adenocarcinoma Recurrent Prostate Carcinoma Stage IV Prostate Cancer Less << Phase 2 Completed - United States, District of Col... More >>umbia MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 Michael Reese Hospital Chicago, Illinois, United States, 60616 University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc - Jefferson Boulevard Fort Wayne, Indiana, United States, 46804 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 University of Maryland Saint Joseph Medical Center Towson, Maryland, United States, 21204 United States, Missouri Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT01244191 Non Squamous, Non-small-cell L... More >>ung Cancer Less << Phase 3 Completed - -
NCT01447914 Refractory Multiple Myeloma Phase 2 Completed - United States, Texas ... More >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00988741 Unresectable Hepatocellular Ca... More >>rcinoma Less << Phase 2 Completed - United States, California ... More >> Los Angeles, California, United States, 90048 United States, Florida Tampa, Florida, United States, 33612 United States, Texas Galveston, Texas, United States, 77555 Belgium Brussels, Belgium, 1070 Brussels, Belgium, 1200 Gent, Belgium, 9000 Canada Toronto, Canada, M5G 2N2 Vancouver, Canada, V5Z 1M9 Germany Essen, Germany, 45123 Frankfurt am Main, Germany, D-60594 Hamburg, Germany, 20099 Munchen, Germany, 81337 Munchen, Germany, 81657 Italy Avellino, Italy, 83100 Benevento, Italy, 82100 Bologna, Italy, 40138 Padova, Italy, 35128 Parma, Italy, 43126 Pavia, Italy, 27100 Pisa, Italy, 56100 Reggio Emilia, Italy, 42100 Roma, Italy, 00168 Rozzano Milano, Italy, 20089 Less <<
NCT01861301 Epithelioid Mesothelioma ... More >> Recurrent Malignant Mesothelioma Sarcomatoid Mesothelioma Stage II Pleural Mesothelioma Stage III Pleural Mesothelioma Stage IV Pleural Mesothelioma Less << Phase 2 Terminated - United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Southern Illinois University School of Medicine Springfield, Illinois, United States, 62702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 Indiana University/Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Missouri Mercy Hospital Saint Louis Saint Louis, Missouri, United States, 63141 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01656265 Advanced Hepatocellular Carcin... More >>oma Less << PHASE1 COMPLETED 2025-03-14 Kashiwa-city, Chiba, Japan
NCT01861301 - Terminated - -
NCT01055067 Non-CNS Germ Cell Tumors (Semi... More >>nomas and Nonseminomas) Less << Phase 2 Completed - United States, California ... More >> Los Angeles, California, United States, 90033 United States, Florida Orlando, Florida, United States, 32806 United States, Indiana Indianapolis, Indiana, United States, 46202 United States, Missouri Saint Louis, Missouri, United States, 63110 United States, New York New York, New York, United States, 10065 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 France Lyon cedex, France, 69373 Villejuif, France, 94800 United Kingdom Leeds, United Kingdom, LS9 7TF London, United Kingdom, SM2 5PT Less <<
NCT02608411 Carcinoma, Small Cell Phase 2 Terminated(Safety results (app... More >>lied in METIV-HCC trial) have led early termination) Less << February 2019 Italy ... More >> Istituto Oncologico Veneto Padova, Italy, 35128 Less <<
NCT01517399 Solid Tumors Phase 1 Completed - United States, Texas ... More >> START - South Texas Accelerated Research Therapeutics, LLC San Antonio, Texas, United States, 78229 Less <<
NCT01611857 Malignant Solid Tumour ... More >> Gastroesophageal Cancer Less << Phase 1 Phase 2 Completed - United States, Connecticut ... More >> Yale University School of Medicine New Haven, Connecticut, United States, 06520 United States, Florida Florida Cancer Specialists-South Fort Myers, Florida, United States, 33916 Florida Cancer Specialists-Sarasota Sarasota, Florida, United States, 34232 Florida Cancer Specialists-North St. Petersburg, Florida, United States, 33705 United States, Oklahoma Oklahoma University Oklahoma City, Oklahoma, United States, 73104 United States, South Carolina South Carolina Oncology Associates Columbia, South Carolina, United States, 29210 United States, Tennessee Tennessee Oncology - Chattanooga Chattanooga, Tennessee, United States, 37404 Tennessee Oncology, PLLC Nashville, Tennessee, United States, 37023 United States, Texas Center for Cancer and Blood Disorders Fort Worth, Texas, United States, 76104 Less <<
NCT01251796 Advanced/Recurrent Non-small-c... More >>ell Lung Cancer Less << Phase 1 Completed - Japan ... More >> Shizuoka, Japan Less <<
NCT02150733 Hepatic Impairment ... More >> Solid Tumor Cancer Less << Phase 1 Completed - United States, California ... More >> USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, New Jersey Hackensack, New Jersey, United States Less <<
NCT01749384 Solid Neoplasm Phase 1 Completed - United States, Pennsylvania ... More >> Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT01611857 - Completed - -
NCT01725191 Childhood Solid Neoplasm Phase 1 Completed - -
NCT01625156 Adult Solid Neoplasm Phase 1 Completed - United States, Wisconsin ... More >> University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Wisconsin Clinical Cancer Center Milwaukee, Wisconsin, United States, 53226 Less <<
NCT01149720 Solid Tumors Phase 1 Completed - United States, California ... More >> Premiere Oncology Santa Monica, California, United States, 90404 United States, Florida Florida Cancer Specialists Fort Myers, Florida, United States, 33916 United States, Tennessee Sarah Cannon Research Institute (SCRI) Nashville, Tennessee, United States, 37203 United States, Texas START - South Texas Accelerated Research Therapeutics, LLC San Antonio, Texas, United States, 78229 Less <<
NCT01755767 Hepatocellular Carcinoma Phase 3 Completed - -
NCT01892527 Colorectal Cancer Metastatic ... More >> C-met Overexpression Less << Phase 2 Unknown March 2017 Italy ... More >> Istituto Clinico Humanitas Rozzano, Milano, Italy, 20089 Less <<
NCT01395758 Metastatic Non-Small Cell Lung... More >> Cancer Less << Phase 2 Completed - United States, California ... More >> Stanford, California, United States, 94305 United States, District of Columbia Washington, District of Columbia, United States, 20057 United States, Florida Weston, Florida, United States, 33331 United States, Georgia Atlanta, Georgia, United States, 30341 United States, Illinois Chicago, Illinois, United States, 60611 United States, Kansas Kansas City, Kansas, United States, 66160 United States, Maryland Baltimore, Maryland, United States, 21205 United States, Massachusetts Boston, Massachusetts, United States, 02114 Burlington, Massachusetts, United States, 01805 United States, New York New York, New York, United States, 10016 United States, Pennsylvania Pittsburgh, Pennsylvania, United States, 15232 United States, South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Dallas, Texas, United States, 75390 Less <<
NCT01069757 Non-small-cell Lung Cancer Phase 1 Completed - Japan ... More >> Osaka, Japan Shizuoka, Japan Less <<
NCT02049060 Malignant Pleural Mesothelioma... More >>|Nonsquamous Nonsmall Cell Neoplasm of Lung Less << PHASE1|PHASE2 COMPLETED 2025-12-17 Istituto Clinico Humanitas, Ro... More >>zzano, Milan, 20089, Italy Less <<
NCT01699061 Solid Tumors Phase 1 Completed - United States, Texas ... More >> START - South Texas Accelerated Research Therapeutics, LLC San Antonio, Texas, United States, 78229 Less <<
NCT01395758 - Completed - -
NCT01447914 - Completed - -

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