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Chemical Structure| 89488-25-5 Chemical Structure| 89488-25-5
Chemical Structure| 89488-25-5

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CAS No.: 89488-25-5

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Product Details of [ 89488-25-5 ]

CAS No. :89488-25-5
Formula : C6H6BClO3
M.W : 172.37
SMILES Code : OB(C1=CC(Cl)=CC=C1O)O
MDL No. :MFCD06659863
Boiling Point : No data available
InChI Key :GGZASRFCRAZNPO-UHFFFAOYSA-N
Pubchem ID :23005362

Safety of [ 89488-25-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 89488-25-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 89488-25-5 ]

[ 89488-25-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6287-82-7 ]
  • [ 89488-25-5 ]
  • 2-(3-bromobenzo(b)thiophen-2-yl)-4-chlorophenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 90℃; for 6h;Schlenk technique; 1) accurate weighing 2, 3 - b bromophenylacetic and [b] Thiophene (300 mg, 1.0 mmol), 5 - chloro -2 - hydroxy phenyl boronic acid (300 mg, 1.6 mmol), and in turn to 25 ml of in shu Lunke bottle, adding potassium carbonate (414 mg, 3 mmol), four (triphenylphosphine) palladium (0.05 equivalent), 1, 4 - dioxane/water (volume ratio 4:1), is 90 C reaction in oil bath 6 hours. After the reaction, the solvent is removed under reduced pressure, the use of silica gel column separation, petroleum ether/ethyl acetate as eluant, to obtain 2 - (3 - bromophenylacetic and [b] Thiophene -2 - yl) -4 - chlorophenol 3j, the yield is 82%
 

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[ 89488-25-5 ]

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