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Chemical Structure| 879085-55-9 Chemical Structure| 879085-55-9
Chemical Structure| 879085-55-9

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CAS No.: 879085-55-9

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Vismodegib (GDC-0449) is an orally active Hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp and ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively.

Synonyms: GDC-0449

4.5 *For Research Use Only !

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Product Details of Vismodegib

CAS No. :879085-55-9
Formula : C19H14Cl2N2O3S
M.W : 421.30
SMILES Code : O=C(NC1=CC=C(Cl)C(C2=NC=CC=C2)=C1)C3=CC=C(S(=O)(C)=O)C=C3Cl
Synonyms :
GDC-0449
InChI Key :BPQMGSKTAYIVFO-UHFFFAOYSA-N
Pubchem ID :24776445

Safety of Vismodegib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335-H351-H361
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
WM35 melanoma cells 0.5 μM 6 h Vismodegib failed to reduce GLI1 expression, suggesting a crucial role of SMO-independent oncogenic GLI activity in the control of IDO1 expression. PMC11834474
DAOY cells 500 nM 5.0 and 15 min To investigate the inhibitory effect of vismodegib on the Hedgehog signaling pathway and its impact on phosphorylation dynamics. Results showed that vismodegib treatment led to activation of Polo-like Kinase 1 and inhibition of Casein Kinase 2A1. PMC7310537
POP92 10 μM 7 days To evaluate the effect of Vismodegib on the growth of POP92 cells, results showed that Vismodegib significantly reduced the efficacy of UNC1999. PMC6441108
Mz-ChA-1 cells 10 μM 72 h To evaluate the effect of Vismodegib on cell proliferation, results showed that Vismodegib combined with Rapamycin significantly inhibited cell proliferation PMC4366884
Sk-ChA-1 cells 10 μM 72 h To evaluate the effect of Vismodegib on cell proliferation, results showed that Vismodegib combined with Rapamycin significantly inhibited cell proliferation PMC4366884
hepatoma cells 10 μM 36 h To evaluate the inhibitory effect of Vismodegib on the Hedgehog signaling pathway, results showed that Vismodegib could reverse the stimulatory effects of HMGCR on the stemness and metastasis of hepatoma cells. PMC11252768

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
Mice Colorectal cancer patient-derived xenograft model Oral gavage 300 mg/kg Once daily for 9 consecutive days, with a 2-day break, for a total of 21 to 25 days To evaluate the effect of UNC1999 on tumour growth, results showed that UNC1999 significantly reduced tumour volume and weight. PMC6441108
Nude mice Mz-ChA-1 xenograft model Oral 100 mg/kg Twice daily for 27 days To evaluate the inhibitory effect of Vismodegib combined with Rapamycin on tumor growth, results showed that the combination treatment significantly inhibited tumor growth PMC4366884
BALB/c nude mice HCC metastatic model intraperitoneal injection 20 mg/kg once daily for 7 weeks To evaluate the inhibitory effect of Vismodegib on HCC metastasis, results showed that Vismodegib could suppress HMGCR overexpression-induced HCC metastasis. PMC11252768
Mice Math1-Cre/SmoM2 (M-Smo) mice Intraperitoneal injection 75 mg/kg or 100 mg/kg Once daily for 3 days, then every other day until symptomatic progression Vismodegib initially induced transient tumor regression, but after 2 weeks of treatment, tumor cells began to proliferate again, indicating early resistance to Vismodegib. PMC6925218

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03498521 Cancer of Unknown Primary Site Phase 2 Recruiting April 16, 2022 -
NCT03297606 Lymphoma, Non-Hodgkin ... More >> Multiple Myeloma Advanced Solid Tumors Less << Phase 2 Recruiting September 2021 Canada, British Columbia ... More >> BCCA - Vancouver Cancer Centre Recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Daniel John Renouf ?? 604 877-6000 ext 672357 ?? ?? Canada, Ontario London Regional Cancer Program Recruiting London, Ontario, Canada, N6A 5W9 Contact: Stephen Welch ?? 519 685-8640 ?? ?? Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1H 8L6 Contact: John Hilton ?? 613 737-7700 ext 70179 ?? ?? University Health Network Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Lillian Siu ?? 416 946-2911 ?? ?? Canada, Quebec The Jewish General Hospital Recruiting Montreal, Quebec, Canada, H3T 1E2 Contact: Cristiano Ferrario ?? 514 398-8307 Less <<
NCT02788201 Urothelial Carcinoma ... More >> Bladder Cancer Urinary Bladder Neoplasms Less << Phase 2 Recruiting July 1, 2020 United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office ?? 888-624-1937 Less <<
NCT03158389 Glioblastoma, Adult Phase 1 Phase 2 Recruiting September 30, 2024 Germany ... More >> Charité Berlin, Neurosurgery Not yet recruiting Berlin, Germany Knappschaftskrankenhaus Bochum GmbH, Neurology Clinic Not yet recruiting Bochum, Germany University Hospital Bonn, Neurology Clinic Not yet recruiting Bonn, Germany University Hospital Cologne, Neurosurgery Not yet recruiting Cologne, Germany University Hospital Dresden, Neurosurgery Not yet recruiting Dresden, Germany University Hospital Essen, Neurology Clinic Not yet recruiting Essen, Germany University Hospital Frankfurt, Neurooncology Not yet recruiting Frankfurt am Main, Germany University Hospital Heidelberg, Neurology Clinic Recruiting Heidelberg, Germany University Hospital Saarland, Neurosurgery Not yet recruiting Homburg, Germany University Hospital Mainz, Neurosurgery Not yet recruiting Mainz, Germany University Hospital Mannheim, Neurology Clinic Not yet recruiting Mannheim, Germany University Hospital Regensburg, Neurology Clinic Not yet recruiting Regensburg, Germany University Hospital Tuebingen, Neurooncology Not yet recruiting Tübingen, Germany Less <<
NCT01108094 Basal Cell Carcinoma (BCC) ... More >> Skin Cancer Less << Phase 2 Completed - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT02465060 Advanced Malignant Solid Neopl... More >>asm Bladder Carcinoma Breast Carcinoma Cervical Carcinoma Colon Carcinoma Colorectal Carcinoma Endometrial Carcinoma Esophageal Carcinoma Gastric Carcinoma Glioma Head and Neck Carcinoma Kidney Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Lung Carcinoma Lymphoma Malignant Uterine Neoplasm Melanoma Ovarian Carcinoma Pancreatic Carcinoma Plasma Cell Myeloma Prostate Carcinoma Rectal Carcinoma Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Colon Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Glioma Recurrent Head and Neck Carcinoma Recurrent Liver Carcinoma Recurrent Lung Carcinoma Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Pancreatic Carcinoma Recurrent Plasma Cell Myeloma Recurrent Prostate Carcinoma Recurrent Rectal Carcinoma Recurrent Skin Carcinoma Recurrent Thyroid Gland Carcinoma Recurrent Uterine Corpus Carcinoma Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Plasma Cell Myeloma Skin Carcinoma Thyroid Gland Carcinoma Uterine Corpus Cancer Less << Phase 2 Recruiting - -
NCT02073838 Acute Myeloid Leukemia Phase 2 Recruiting June 2018 Canada, Quebec ... More >> Jewish General Hospital Recruiting Montreal, Quebec, Canada, H3T1E2 Contact: Eftihia Cocolakis, PhD ?? 5143408222 ext 3628 ?? ecocolakis@jgh.mcgill.ca ?? Principal Investigator: Sarit Assouline, MD Less <<
NCT01173536 Healthy Volunteer Phase 1 Completed - -
NCT02091141 Neoplasms Sol... More >>id Tumors Biliary Cancer Salivary Cancer Bladder Cancer Less << Phase 2 Recruiting March 31, 2021 -
NCT02925234 Cancer Tumors... More >> Neoplasm Neoplasia Less << Phase 2 Recruiting December 2019 Netherlands ... More >> Meander Medical Center Not yet recruiting Amersfoort, Utrecht, Netherlands, 3818 ES Contact: H.J. Bloemendal, MD, PhD ?? ?? ?? Principal Investigator: H.J. Bloemendal, MD, PhD ?? ?? ?? Netherlands Cancer Institute Recruiting Amsterdam, Netherlands, 1066CX Contact: E.E. Voest, prof. ?? 0031205129111 ?? DRUP@nki.nl ?? Contact: D.L. vd Velden, MD ?? 0031205129111 ?? DRUP@nki.nl ?? AZVU Not yet recruiting Amsterdam, Netherlands, 1081 HV Contact: H Verheul, prof ?? ?? ?? Principal Investigator: H Verheul, prof ?? ?? ?? Amphia Hospital Not yet recruiting Breda, Netherlands Contact: A.J. Ten Tije, MD, PhD ?? ?? ?? Principal Investigator: A.J. Ten Tije, MD, PhD ?? ?? ?? Maxima Medisch Centrum Not yet recruiting Eindhoven, Netherlands, 5631 BM Contact: G Vreugdenhil, MD, PhD ?? ?? ?? Principal Investigator: G Vreugdenhil, MD, PhD ?? ?? ?? Orbis Concern Not yet recruiting Geleen, Netherlands, 6162 BG Contact: F L Erdkamp, MD ?? ?? ?? Principal Investigator: F L Erdkamp, MD ?? ?? ?? University Medical Center Groningen Not yet recruiting Groningen, Netherlands Contact: D.J.A. de Groot, MD, PhD ?? ?? ?? Principal Investigator: D.J.A. de Groot, MD, PhD ?? ?? ?? Leiden University Medical Center Not yet recruiting Leiden, Netherlands Contact: A.J. Gelderblom, MD, PhD ?? ?? ?? Principal Investigator: A.J. Gelderblom, MD, PhD ?? ?? ?? Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands Contact: A. Hoeben, MD, PhD ?? ?? ?? Principal Investigator: A. Hoeben, MD, PhD ?? ?? ?? Radboud umc Not yet recruiting NIjmegen, Netherlands, 6225GA Contact: C.M.L. van Herpen, MD, PhD ?? ?? ?? Principal Investigator: C.M.L. van Herpen, MD, PhD ?? ?? ?? St. Fransicus Gasthuis Not yet recruiting Rotterdam, Netherlands, 3045 PM Contact: A P Hamberg, MD ?? ?? ?? Principal Investigator: A P Hamberg, MD ?? ?? ?? Erasmus MC Not yet recruiting Rotterdam, Netherlands Contact: M.J.A. de Jonge, MD, PhD ?? ?? ?? Principal Investigator: M.J.A. de Jonge, MD, PhD ?? ?? ?? St. Elisabeth Not yet recruiting Tilburg, Netherlands, 5022 GC Contact: L.V. Beerepoot, MD, PhD ?? ?? ?? Principal Investigator: L.V. Beerepoot, MD, PhD ?? ?? ?? University Medical Center Utrecht Not yet recruiting Utrecht, Netherlands, 3584CX Contact: M.H.G. Langenberg, MD, PhD ?? ?? ?? Principal Investigator: M.H.G. Langenberg, MD, PhD Less <<
NCT00968981 Solid Cancers Phase 1 Completed - -
NCT01878617 Medulloblastoma Phase 2 Recruiting December 2026 -
NCT01108094 - Completed - -
NCT00887159 Extensive Stage Small Cell Lun... More >>g Carcinoma Recurrent Small Cell Lung Carcinoma Less << Phase 2 Completed - -
NCT00887159 - Completed - -
NCT00607724 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << PHASE1 COMPLETED 2025-11-09 -
NCT00968981 - Completed - -
NCT00991718 Healthy Phase 1 Completed - -
NCT01088815 Metastatic Pancreatic Cancer Phase 2 Unknown October 2015 United States, Arizona ... More >> Translational Genomics Research Institute (TGen) Scottsdale, Arizona, United States, 85258 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21205 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00982592 Adenocarcinoma of the Gastroes... More >>ophageal Junction Adenocarcinoma of the Stomach Recurrent Gastric Cancer Stage IIIA Gastric Cancer Stage IIIB Gastric Cancer Stage IIIC Gastric Cancer Stage IV Gastric Cancer Less << Phase 2 Completed - United States, California ... More >> University of California at Davis Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 Cancer Care Center of Decatur Decatur, Illinois, United States, 62526 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 Crossroads Cancer Center Effingham, Illinois, United States, 62401 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Loyola University Medical Center Maywood, Illinois, United States, 60153 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Illinois Oncology Research Association CCOP Peoria, Illinois, United States, 61615 Memorial Medical Center Springfield, Illinois, United States, 62781-0001 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 Indiana University Medical Center Indianapolis, Indiana, United States, 46202 United States, Michigan University of Michigan University Hospital Ann Arbor, Michigan, United States, 48109 University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Saint John's Mercy Medical Center Saint Louis, Missouri, United States, 63141 United States, New York New York Cancer Consortium Bronx;, New York, United States, 10461 Albert Einstein College of Medicine Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467-2490 Beth Israel Medical Center New York, New York, United States, 10003 New York University Langone Medical Center New York, New York, United States, 10016 Saint Luke's Roosevelt Hospital Center - Saint Luke's Division New York, New York, United States, 10025 Columbia University Medical Center New York, New York, United States, 10032 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Weill Medical College of Cornell University New York, New York, United States, 10065 United States, Ohio Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Virginia Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less <<
NCT00607724 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << PHASE1 COMPLETED 2025-11-09 -
NCT02168530 Idiopathic Pulmonary Fibrosis Phase 2 Withdrawn January 2017 -
NCT01893892 Musculoskeletal Complications Not Applicable Completed - United States, California ... More >> Stanford University, School of Medicine Stanford, California, United States, 94305 Less <<
NCT02438644 - Completed - -
NCT00982592 - Completed - -
NCT02523014 Intracranial Meningioma ... More >> Recurrent Meningioma NF2 Gene Mutation Less << Phase 2 Suspended(No arms are currentl... More >>y open to patient registration) Less << - -
NCT01160250 - - - United States, Arizona ... More >> Scottsdale, Arizona, United States, 85258 Scottsdale, Arizona, United States, 85259 United States, California Los Angeles, California, United States, 90025 Stanford, California, United States, 94305 United States, Florida Ormond Beach, Florida, United States, 32174 United States, Michigan Detroit, Michigan, United States, 48201 United States, New York New York, New York, United States, 10029 United States, Ohio Columbus, Ohio, United States, 43210 United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee Nashville, Tennessee, United States, 37203 United States, Texas Houston, Texas, United States, 77030 Less <<
NCT00822458 Recurrent Childhood Medullobla... More >>stoma Less << Phase 1 Completed - United States, California ... More >> UCSF-Mount Zion San Francisco, California, United States, 94115 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60614 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Pediatric Brain Tumor Consortium Memphis, Tennessee, United States, 38105 St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 Less <<
NCT00980343 Adult Giant Cell Glioblastoma ... More >> Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Less << Phase 2 Completed - United States, California ... More >> University of California at Los Angeles Los Angeles, California, United States, 90095 University of California San Francisco San Francisco, California, United States, 94115 United States, Georgia Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Ohio University Hospitals Case Medical Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pennsylvania/Abramson Cancer Center Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT01367665 Basal Cell Carcinoma Phase 2 Completed - -
NCT00980343 - Completed - -
NCT01772290 Healthy Volunteer Phase 1 Completed - United States, Florida ... More >> Daytona Beach, Florida, United States, 32117 United States, Texas Dallas, Texas, United States, 75247 Less <<
NCT00878163 Adult Solid Neoplasm ... More >> Pancreatic Acinar Cell Carcinoma Pancreatic Ductal Adenocarcinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer AJCC v6 and v7 Less << Phase 1 Active, not recruiting - United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 UF Cancer Center at Orlando Health Orlando, Florida, United States, 32806 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT02781389 - Active, not recruiting April 2021 Germany ... More >> Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (Universit?tsklinikum Essen) Essen, Germany, 45122 Less <<
NCT01071564 Estrogen Receptor Negative ... More >> HER2/Neu Negative Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Triple-Negative Breast Carcinoma Less << Phase 1 Terminated - United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Baltimore, Maryland, United States, 21287 United States, Michigan University of Michigan University Hospital Ann Arbor, Michigan, United States, 48109 Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less <<
NCT01096732 Pancreatic Ductal Adenocarcino... More >>ma Less << PHASE2 TERMINATED 2025-08-12 Cambridge University Hospitals... More >> NHS Foundation Trust, Cambridge, CB2 0QQ, United Kingdom Less <<
NCT01163084 Prostate Adenocarcinoma ... More >> Stage IIA Prostate Cancer AJCC v7 Stage IIB Prostate Cancer AJCC v7 Less << Phase 1 Phase 2 Terminated - United States, Michigan ... More >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT01537107 Acinar Cell Adenocarcinoma of ... More >>the Pancreas Duct Cell Adenocarcinoma of the Pancreas Recurrent Pancreatic Cancer Stage IV Pancreatic Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 1 Suspended December 2018 United States, Arizona ... More >> Mayo Clinic Campus in Arizona Scottsdale, Arizona, United States United States, Florida Mayo Clinic Campus in Florida Jacksonville, Florida, United States, 32224 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT01209143 Solid Cancers Phase 1 Completed - United States, California ... More >> Stanford, California, United States, 94305 United States, Michigan Detroit, Michigan, United States, 48201 United States, Texas Houston, Texas, United States, 77030 Less <<
NCT01064622 Adenocarcinoma of the Pancreas... More >> Recurrent Pancreatic Cancer Stage IV Pancreatic Cancer Less << Phase 1 Phase 2 Completed - United States, California ... More >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Medical Center Duarte, California, United States, 91010 University of Southern California/Norris Cancer Center Los Angeles, California, United States, 90033 City of Hope Medical Group Inc Pasadena, California, United States, 91105 University of California at Davis Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Loyola University Medical Center Maywood, Illinois, United States, 60153 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 60702 Southern Illinois University Springfield, Illinois, United States, 62702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 University of Maryland Saint Joseph Medical Center Towson, Maryland, United States, 21204 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Saint John's Mercy Medical Center Saint Louis, Missouri, United States, 63141 United States, New York Montefiore Medical Center-Weiler Division Bronx, New York, United States, 10461 Montefiore Medical Center Bronx, New York, United States, 10467-2490 New York University Clinical Cancer Center New York, New York, United States, 10016-4760 New York University Langone Medical Center New York, New York, United States, 10016 Weill Medical College of Cornell University New York, New York, United States, 10065 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less <<
NCT01209143 - Completed - -
NCT01195415 Recurrent Pancreatic Carcinoma... More >> Stage IV Pancreatic Cancer Less << Phase 2 Completed - United States, Michigan ... More >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Less <<
NCT01154452 - Completed - -
NCT01154452 Adult Alveolar Soft Part Sarco... More >>ma Adult Angiosarcoma Adult Desmoplastic Small Round Cell Tumor Adult Epithelioid Hemangioendothelioma Adult Epithelioid Sarcoma Adult Extraskeletal Myxoid Chondrosarcoma Adult Extraskeletal Osteosarcoma Adult Fibrosarcoma Adult Leiomyosarcoma Adult Liposarcoma Adult Malignant Mesenchymoma Adult Malignant Peripheral Nerve Sheath Tumor Adult Rhabdomyosarcoma Adult Synovial Sarcoma Adult Unclassified Pleomorphic Sarcoma Chondrosarcoma Clear Cell Sarcoma of the Kidney Conjunctival Kaposi Sarcoma Dermatofibrosarcoma Protuberans Gastrointestinal Stromal Tumor Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Metastatic Osteosarcoma Ovarian Sarcoma Recurrent Adult Soft Tissue Sarcoma Recurrent Adult Unclassified Pleomorphic Sarcoma of Bone Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Kaposi Sarcoma Recurrent Osteosarcoma Recurrent Uterine Corpus Sarcoma Small Intestine Leiomyosarcoma Stage III Adult Soft Tissue Sarcoma Stage III Uterine Sarcoma Stage IV Adult Soft Tissue Sarcoma Stage IV Uterine Sarcoma Unclassified Pleomorphic Sarcoma of Bone Less << Phase 1 Phase 2 Completed - United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT01880437 Myelodysplastic Syndromes, Mye... More >>logenous Leukemia, Acute Less << Phase 2 Terminated - United States, California ... More >> Stanford, California, United States, 94305 United States, Michigan Ann Arbor, Michigan, United States, 48109 United States, Missouri Kansas City, Missouri, United States, 64131 United States, New York New York, New York, United States, 10065 United States, Texas Houston, Texas, United States, 77030 Canada, Alberta Edmonton, Alberta, Canada, T6L5X8 Canada, Ontario Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec Montreal, Quebec, Canada, H1T 2M4 Montreal, Quebec, Canada, H3T 1E2 Germany Braunschweig, Germany, 38114 Essen, Germany, 45122 Hamburg, Germany, 20246 Heidelberg, Germany, 69120 Münster, Germany, 48149 Less <<
NCT01880437 - Terminated - -
NCT02690948 Skin Basal Cell Carcinoma Phase 1 Phase 2 Active, not recruiting July 19, 2020 United States, California ... More >> Stanford University School of Medicine Palo Alto, California, United States, 94304 Less <<
NCT01064622 - Completed - -
NCT00959647 - Completed - -
NCT01195415 - Completed - -
NCT01267955 Clear Cell Chondrosarcoma ... More >> Dedifferentiated Chondrosarcoma Mesenchymal Chondrosarcoma Metastatic Chondrosarcoma Primary Central Chondrosarcoma Less << Phase 2 Active, not recruiting - France ... More >> Institut Bergonie Cancer Center Bordeaux, France, 33076 Centre Oscar Lambert Lille, France, 59020 Centre Leon Berard Lyon, France, 69373 Hopital De La Timone Marseille, France, 13385 Institut Curie Paris Paris, France, 75005 Gustave Roussy Villejuif, France, 94805 Less <<
NCT00636610 - Completed - -
NCT01174264 Malignant Neoplasm Phase 1 Phase 2 Completed - United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 Less <<
NCT00959647 Ovarian Cancer ... More >> Basal Cell Carcinoma Metastatic Colorectal Cancer Less << Phase 2 Completed - United States, Arizona ... More >> Scottsdale, Arizona, United States, 85258 United States, California Oakland, California, United States, 94609 Palm Springs, California, United States, 92262 Stanford, California, United States, 94305 United States, Maryland Baltimore, Maryland, United States, 21231 United States, Michigan Ann Arbor, Michigan, United States, 48109-0934 Detroit, Michigan, United States, 48201 United States, Nevada Las Vegas, Nevada, United States, 89106 United States, Ohio Cincinnati, Ohio, United States, 45242 United States, Texas Houston, Texas, United States, 77030 Less <<
NCT01174264 - Completed - -
NCT00636610 Metastatic Colorectal Cancer Phase 2 Completed - -
NCT02694224 Breast Cancer Phase 2 Recruiting December 2018 Spain ... More >> Clínica Universidad de Navarra Recruiting Pamplona, Navarra, Spain, 31008 Contact: Amaya Izal ?? +34948255400 ext 2724 ?? aizal@unav.es Less <<
NCT02436408 Carcinoma, Basal Cell PHASE4 COMPLETED 2025-09-20 University of Michigan Hospita... More >>l, Ann Arbor, Michigan, 48109, United States Less <<
NCT01898598 Basal Cell Carcinoma Phase 2 Terminated - United States, Arizona ... More >> Mayo Clinic Scottsdale, Arizona, United States, 85259 United States, California Moy-Fincher-Chipps Facial Plastics and Dermatology Beverly Hills, California, United States, 90210 Scripps Clinic La Jolla, California, United States, 92037 Loma Linda University Medical Center Loma Linda, California, United States, 92354 Stanford University Palo Alto, California, United States, 94305 California Pacific Medical Center San Francisco, California, United States, 94107 Univ of Calif-San Francisco San Francisco, California, United States, 94115 United States, Florida Spencer Derma & Skin Surg Ctr St. Petersburg, Florida, United States, 33716 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Indiana Laser & Skin Surgery Center of Indiana Carmel, Indiana, United States, 46032 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55455 United States, New York Beth Israel Cancer Center; West Campus New York, New York, United States, 10011 University of Rochester Medical Center; University Dermatology Associates Rochester, New York, United States, 14642 Mariwalla Dermatology West Islip, New York, United States, 11795 United States, North Carolina The Skin Surgery Center Winston-Salem, North Carolina, United States, 27106 United States, Oregon Oregon Health & Science University; Department of Dermatology Portland, Oregon, United States, 97239-4501 United States, Pennsylvania Penn State Milton S. Hershey Medical Center Hershey, Pennsylvania, United States, 17033 Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-4095 United States, Utah Huntsman Cancer Institute at The University of Utah Salt Lake City, Utah, United States, 84112 United States, Wisconsin University of Wisconsin Madison, Wisconsin, United States, 53792 Less <<
NCT00957229 Basal Cell Nevus Syndrome|Gorl... More >>in Syndrome Less << PHASE2 COMPLETED 2025-01-14 Children's Hospital Oakland Re... More >>search Institiute, Oakland, California, 94609, United States|Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York, New York, 10032, United States Less <<
NCT01898598 - Terminated - -
NCT01330173 DS Stage I Plasma Cell Myeloma... More >> DS Stage II Plasma Cell Myeloma DS Stage III Plasma Cell Myeloma Refractory Plasma Cell Myeloma Less << Phase 1 Completed - United States, Maryland ... More >> University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital Baltimore, Maryland, United States, 21231 Less <<
NCT01713218 Pancreatic Adenocarcinoma Rese... More >>ctable Less << Early Phase 1 Unknown December 2016 Belgium ... More >> Antwerp University Hospital (UZA) Not yet recruiting Edegem, Antwerpen, Belgium, 2650 Contact: Marc Peeters, MD,PhD ?? ?? marc.peeters@uza.be ?? Principal Investigator: Marc Peeters, MD, PhD ?? ?? ?? Erasme University Hospital (ULB) Not yet recruiting Brussels, Belgium, 1070 Contact: Jean-Luc Van Laethem, MD, PhD ?? ?? jl.vanlaethem@erasme.ulb.ac.be ?? Principal Investigator: Jean-Luc Van Laethem, MD, PhD ?? ?? ?? Sub-Investigator: Rapha?l Maréchal, MD, PhD ?? ?? ?? Sub-Investigator: Anne Demols, MD, PhD Less <<
NCT02337517 Chronic Graft Versus Host Dise... More >>ase Less << Not Applicable Recruiting - United States, Michigan ... More >> University of Michigan Comprehensive Cancer Center Suspended Ann Arbor, Michigan, United States, 48109 United States, Utah Huntsman Cancer Institute/University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Daniel R. Couriel ?? 801-581-4477 ?? clinical.trials@hci.utah.edu ?? Principal Investigator: Daniel R. Couriel Less <<
NCT01546519 Cancer PHASE1 COMPLETED 2025-04-14 Chicago, Illinois, 60637, Unit... More >>ed States|Baltimore, Maryland, 21201, United States|Detroit, Michigan, 48201, United States|Lebanon, New Hampshire, 03756, United States|New York, New York, 10017, United States Less <<
NCT02674009 Carcinoma, Basal Cell COMPLETED 2019-03-31 Klinik Johann Wolfgang von Goe... More >>the Uni; Klinik für Dermatologie, Venerologie und Allergologie, Frankfurt, 60590, Germany Less <<
NCT00939484 Adult Medulloblastoma Phase 2 Completed - United States, California ... More >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States, 94304 UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60611 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Pediatric Brain Tumor Consortium Memphis, Tennessee, United States, 38105 St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Less <<
NCT00939484 - Completed - -
NCT00739661 Ovarian Cancer Phase 2 Completed - -
NCT00739661 - Completed - -
NCT01546519 Cancer PHASE1 COMPLETED 2025-04-14 Chicago, Illinois, 60637, Unit... More >>ed States|Baltimore, Maryland, 21201, United States|Detroit, Michigan, 48201, United States|Lebanon, New Hampshire, 03756, United States|New York, New York, 10017, United States Less <<
NCT02593760 Myelofibrosis Phase 1 Completed - United States, Florida ... More >> Florida Cancer Specialists-Broadway, Fort Myers Fort Myers, Florida, United States, 33908 Florida Cancer Specialist, North Region Saint Petersburg, Florida, United States, 33705 Florida Cancer Specialists West Palm Beach, Florida, United States, 33401 United States, Ohio Oncology Hematology Care Inc Cincinnati, Ohio, United States, 45242 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 United States, Texas Uni of Texas - Md Anderson Cancer Center; Dept of Leukemia Houston, Texas, United States, 77030 Canada, Alberta Tom Baker Cancer Centre-Calgary; Clinical Research Unit Calgary, Alberta, Canada, T2N 4N2 Canada, Nova Scotia Queen Elizabeth II Health Sciences Centre; Oncology Halifax, Nova Scotia, Canada, B3H 2Y9 Canada, Quebec Centre Hospitalier De L'Universite De Montreal, Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 Germany Uniklinik RWTH Aachen; Med. Klinik IV; Klinik für H?matologie, Onkologie, H?mostaseologie und Stammz Aachen, Germany, 52074 Campus Virchow-Klinikum Charité Centrum 14; Medizinische Klinik m.S. H?matologie u. Onkologie Berlin, Germany, 13353 Italy A.O.U. Citta' Della Salute E Della Scienza-P.O. Molinette;S.C. Ematologia Torino, Piemonte, Italy, 10126 Az. Osp. Di Careggi; Divisione Di Ematologia Firenze, Toscana, Italy, 50135 Less <<
NCT00833417 - Completed - -
NCT01601184 Histologically Confirmed Medul... More >>loblastoma Activation of the Sonic Hedgehog (SHH) Pathway Less << Phase 1 Phase 2 Terminated(The number of succe... More >>sses is not reached at the end of first stage of the phase II. The study is stopped.) Less << - France ... More >> CHU La Timone Marseille, Bouches Du Rh?ne, France, 13385 Institut Claudius Régaud (iuct-oncopole) Toulouse, Haute-Garonne, France, 31059 Hopital de La Pitié Salpétrière Paris, Ile De France, France, 75013 Institut de Cancérologie de l'Ouest - René Gauducheau St Herblain, Loire Atlantique, France, 44805 Hopital Central de Nancy Nancy, Meurthe Et Moselle, France, 54035 CHBS H?pital du Scorff Lorient, Morbihan, France, 56322 CHRU de Lille Lille, Nord, France, 59037 Centre Léon Bérard Lyon, Rhone, France, 69373 Institut de Cancérologie de l'Ouest - Paul Papin Angers, France, 49933 Institut Bergonié Bordeaux, France, 33076 Italy BELLARIA Ospedale Bologna, Italy, 40139 University of Turin Torino, Italy, 10126 Switzerland Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne, Switzerland, CH-8091 University Hospital Zurich Zurich, Switzerland, CH-8091 United Kingdom University College London Hospital - Mount Vernon Cancer Centre - Mount Vernon hospital London, United Kingdom, London-NW1-2PG Less <<
NCT01239316 - Completed - -
NCT01239316 Recurrent Childhood Medullobla... More >>stoma Less << Phase 2 Completed - United States, California ... More >> Children's Hospital Los Angeles Los Angeles, California, United States, 90027 Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States, 94304 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60611 United States, Maryland National Cancer Institute Pediatric Oncology Branch Bethesda, Maryland, United States, 20892 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 Less <<
NCT01631331 Basal Cell Carcinoma of the Sk... More >>in Recurrent Skin Cancer Less << Early Phase 1 Completed - United States, California ... More >> Stanford University Stanford, California, United States, 94305 Less <<
NCT00833417 Basal Cell Carcinoma Phase 2 Completed - -
NCT01631331 - Completed - -
NCT02371967 Basal Cell Carcinoma COMPLETED 2020-08-19 SU/Sahlgrenska, Hudkliniken, G... More >>?teborg, 41345, Sweden|Sk?nes Universitetssjukhus; Hudkliniken, Lund, 222 41, Sweden|Radiumhemmet, Solna, 171 64, Sweden|Norrlands universitetssjukhus; Onkologkliniken, Ume?, Sweden Less <<
NCT01815840 Basal Cell Carcinoma Phase 2 Completed - -
NCT01815840 - Completed - -
NCT01700049 Basal Cell Carcinoma Phase 2 Active, not recruiting July 2018 United States, Florida ... More >> Mayo Clinic - Florida Jacksonville, Florida, United States, 32224 United States, Missouri Saint Louis University Dermatology Saint Louis, Missouri, United States, 63104 Less <<
NCT03052478 Stomach Neoplasms Phase 2 Recruiting September 30, 2019 Korea, Republic of ... More >> Samsung Medical Center Recruiting Seoul City, Seoul, Korea, Republic of, 135710 Contact: Sung Ju Park Less <<
NCT01201915 Basal Cell Carcinoma PHASE2 COMPLETED 2025-05-13 Scottsdale, Arizona, 85259, Un... More >>ited States|Los Angeles, California, 90045, United States|Redwood City, California, 94063, United States|San Diego, California, 92117, United States|St. Petersburg, Florida, 33716, United States|Alpharetta, Georgia, 30005, United States|Chicago, Illinois, 60611, United States|Louisville, Kentucky, 40217, United States|Philadelphia, Pennsylvania, 19111, United States|Bartlett, Tennessee, 38134, United States|Houston, Texas, 77030, United States|Madison, Wisconsin, 53705, United States Less <<
NCT01835626 Locally Advanced Basal Cell Ca... More >>rcinoma Skin Cancer Cutaneous Malignancy Less << Phase 2 Recruiting June 2019 United States, California ... More >> University of California, San Francisco Recruiting San Francisco, California, United States, 94115 Contact: Kyusun Cha ?? 877-827-3222 ?? clinicaltrials@ucsf.edu ?? Principal Investigator: Sue Yom, MD ?? ?? ?? Principal Investigator: Chris Barker, MD, PhD ?? ?? ?? United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Ming Lian ?? 212-639-8074 ?? lianm@mskcc.org Less <<
NCT01774253 Pontine Glioma PHASE2 TERMINATED 2025-10-15 Phoenix Children's Hospital, P... More >>hoenix, Arizona, 85016, United States|Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States Less <<
NCT01774253 Pontine Glioma PHASE2 TERMINATED 2025-10-15 Phoenix Children's Hospital, P... More >>hoenix, Arizona, 85016, United States|Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States Less <<
NCT02648048 Idiopathic Pulmonary Fibrosis Phase 1 Completed - United States, California ... More >> Scripps Clinic La Jolla, California, United States, 92037 United States, Florida Central Florida Pulmonary Group, PA Orlando, Florida, United States, 32803 United States, Illinois Suburban Lung Associates Elk Grove, Illinois, United States, 60007 United States, Indiana Medical Consultants, PC ; Pulmonary Muncie, Indiana, United States, 47303 United States, Kentucky University of Louisville Louisville, Kentucky, United States, 40202-1798 United States, Louisiana Tulane University Medical School New Orleans, Louisiana, United States, 70112 United States, Massachusetts Steward St. Elizabeth's Medical Center ; Pulmonary, Critical Care and Sleep Medicine Boston, Massachusetts, United States, 02135 United States, Nebraska Creighton University Medical Center Omaha, Nebraska, United States, 68131 United States, Nevada Allied Clinical Research Reno, Nevada, United States, 89503 United States, New Jersey Atlantic Respiratory Institute Summit, New Jersey, United States, 07901 United States, North Carolina Pulmonix LLC Greensboro, North Carolina, United States, 27403 PMG Research of Wilmington Wilmington, North Carolina, United States, 28401 United States, Washington Western Washington Medical Group Everett, Washington, United States, 98208 Swedish Medical Center Seattle, Washington, United States, 98122 Germany Fraunhofer-Institut fur Toxikologie und Experimentelle Medizin ITEM Hannover, Germany, 30625 Less <<
NCT01201915 Basal Cell Carcinoma PHASE2 COMPLETED 2025-05-13 Scottsdale, Arizona, 85259, Un... More >>ited States|Los Angeles, California, 90045, United States|Redwood City, California, 94063, United States|San Diego, California, 92117, United States|St. Petersburg, Florida, 33716, United States|Alpharetta, Georgia, 30005, United States|Chicago, Illinois, 60611, United States|Louisville, Kentucky, 40217, United States|Philadelphia, Pennsylvania, 19111, United States|Bartlett, Tennessee, 38134, United States|Houston, Texas, 77030, United States|Madison, Wisconsin, 53705, United States Less <<
NCT02667574 Basal Cell Carcinoma Phase 2 Active, not recruiting December 2020 France ... More >> CHU de Besan?on Besan?on, France, 25030 H?pital St André Bordeaux, France, 33075 CH de Boulogne sur mer Boulogne sur mer, France, 62321 CHU - H?pital d'Estaing Clermont-Ferrand, France, 63003 CHU Bocage Dijon, France, 21079 Clinique de Dermatologie Lille, France, 59037 H?pital de la Timone Marseille, France, 13885 H?pital Saint Eloi Montpellier, France, 34295 H?pital Bichat Paris, France, 75018 H?pital Saint-Louis Paris, France, 75475 CHU Ambroise Paré Paris, France, 92104 H?pital Haut-Lévêque Pessac, France, 33604 Centre hospitalier Lyon Sud Pierre-benite, France, 69495 H?pital Robert Debré Reims, France, 51100 H?pital Pontchaillou Rennes, France, 35033 H?pitaux de Brabois Vandoeuvre Les Nancy, France, 54500 Institut Gustave Roussy Villejuif, France, 94805 Less <<
NCT01944943 Diffuse Large B-cell Lymphoma|... More >>Indolent Non-hodgkin Lymphoma|Primary Central Nervous System Lymphoma|Chronic Lymphocytic Leukemia Less << PHASE2 TERMINATED 2025-10-14 H?pital Henri MONDOR, Creteil,... More >> 94010, France|CHU Dijon _ H?pital d'Enfants, Dijon, 21000, France|CHRU de Lille _ H?pital Huriez, Lille, 59800, France|CHU de Nantes _ H?tel Dieu, Nantes, 44093, France|H?pital Saint-Louis, Paris, 75475, France|CHU Haut Lévèque, Pessac, 33604, France|CH Lyon Sud, Pierre-Bénite, 69495, France|CHU Pontchaillou, Rennes, 35003, France|Centre Henri Becquerel, Rouen, 76038, France|H?pital René Huguenin _ Institut Curie, Saint-Cloud, 92210, France Less <<
NCT02067104 Basal Cell Carcinomas Phase 2 Active, not recruiting December 31, 2019 United States, Arizona ... More >> University of Arizona Cancer Center Tucson, Arizona, United States, 85724 Less <<
NCT01543581 - Completed - -
NCT03767439 Basal Cell Nevus Syndrome Phase 2 Not yet recruiting February 2020 -
NCT02956889 Carcinoma, Basal Cell Phase 2 Recruiting November 2019 Italy ... More >> Istituto Clinico humanitas Recruiting Rozzano, Mi, Italy, 20089 Contact: Armando Santoro, MD ?? 02 8224 ext 4080 ?? Armando.santoro@humanitas.it ?? Contact: Maria C Tronconi, MD ?? 02 8224 ext 4593 ?? Maria_chiara.tronconi@humanitas.it ?? Principal Investigator: Armando Santoro, MD ?? ?? ?? Sub-Investigator: Maria C Tronconi, MD Less <<
NCT02115828 Prostate Cancer EARLY_PHASE1 COMPLETED 2025-04-16 Johns Hopkins Hospital, Baltim... More >>ore, Maryland, 21205, United States Less <<
NCT01556009 Basal Cell Nevus Syndrome ... More >> Gorlin's Syndrome Less << Phase 2 Completed - United States, California ... More >> Children's Hospital Oakland Research Institiute Oakland, California, United States, 94609 Children's Hospital Research Center Oakland Oakland, California, United States, 94609 United States, New York Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 Less <<
NCT01543581 Basal Cell Carcinoma Phase 2 Completed - -
NCT02366312 Keratocystic Odontogenic Tumor Phase 2 Active, not recruiting May 2019 United States, New York ... More >> NYU Bluestone Center For Cllinical Research New York, New York, United States, 10010 Less <<
NCT03035188 Basal Cell Carcinoma PHASE2 COMPLETED 2025-01-21 SRH Wald-Klinikum Gera GmbH, G... More >>era, Thuringia, 07548, Germany|Klinikum Augsburg Süd, Augsburg, 86179, Germany|Charité - Universit?tsmedizin Berlin, Berlin, 10117, Germany|Elbe Kliniken Stade - Buxtehude GmbH, Buxtehude, 21614, Germany|Universit?tsklinik Carl Gustav Carus der Technischen Universit?t Dresden, Dresden, 01307, Germany|HELIOS Klinikum Erfurt, Erfurt, 99089, Germany|Universit?tsklinikum Leipzig, Leipzig, 04103, Germany|Universit?tsklinikum Münster, Münster, 48149, Germany|Fachklinik Hornheide, Münster, 48157, Germany|Klinikum Nürnberg Nord, Nürnberg, 90419, Germany|Harzklinikum Dorothea Christiane Erxleben GmbH, Quedlinburg, 06484, Germany|Universit?tsklinikum Tübingen, Tübingen, 72076, Germany Less <<
NCT02115828 Prostate Cancer EARLY_PHASE1 COMPLETED 2025-04-16 Johns Hopkins Hospital, Baltim... More >>ore, Maryland, 21205, United States Less <<
NCT03610022 Metastatic Basal Cell Carcinom... More >>a Locally Advanced Basal Cell Carcinoma Less << Phase 4 Not yet recruiting July 2020 -
NCT02639117 Basal Cell Carcinoma PHASE1 COMPLETED 2017-11-18 Arizona Cancer Center, Tucson,... More >> Arizona, 85719, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.87mL

2.37mL

1.19mL

23.74mL

4.75mL

2.37mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories