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[ CAS No. 867-56-1 ] {[proInfo.proName]}

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Chemical Structure| 867-56-1
Chemical Structure| 867-56-1
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Acikalin ; Merve Yalcin ; Dokur , et al. DOI:

Abstract: This study presents the development of a selective sensor for the electrochemical determination of riboflavin. In the first step, electropolymerization of 3,4-ethylenedioxythiophene (EDOT) was carried out on the pencil graphite electrode to prepare the modified electrode (PEDOT/PGE). In the second step, we prepared over-oxidized poly(3,4-ethylene-dioxythiophene) pencil graphite electrode (OOPEDOT/PGE) by chronoamperometry method in pH 7.0 phosphate buffer solution. In the final step, silver nanoparticles were deposited on the OOPEDOT/PGE by chronoamperometry. The sensitivity of the developed AgNp/OOPEDOT/PGE sensor to riboflavin has been improved. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR) were used to characterize the sensor. The surface morphology of the sensor was examined using field emission scanning electron microscopy (FESEM). The limit of detection (LOD) value was determined to be 0.51?μmol L?1 and a linear range of 0.8 and 80?μmol L?1 using differential pulse voltammetry (DPV). The sensor demonstrated excellent resistance to interference from dopamine (DA), glucose (G), uric acid (UA), and lactate (LA). The study investigated the applicability of the constructed sensor to real samples and achieved good recovery values. The results indicate that the modified electrode is suitable for riboflavin determination applications.

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Product Details of [ 867-56-1 ]

CAS No. :867-56-1 MDL No. :MFCD00066576
Formula : C3H5NaO3 Boiling Point : -
Linear Structure Formula :- InChI Key :NGSFWBMYFKHRBD-DKWTVANSSA-M
M.W : 112.06 Pubchem ID :23664767
Synonyms :
Sodium L-lactate

Calculated chemistry of [ 867-56-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 7
Num. arom. heavy atoms : 0
Fraction Csp3 : 0.67
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 17.53
TPSA : 60.36 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -7.49 cm/s

Lipophilicity

Log Po/w (iLOGP) : -6.99
Log Po/w (XLOGP3) : -0.72
Log Po/w (WLOGP) : -1.88
Log Po/w (MLOGP) : -0.85
Log Po/w (SILICOS-IT) : -0.8
Consensus Log Po/w : -2.25

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.02
Solubility : 108.0 mg/ml ; 0.966 mol/l
Class : Very soluble
Log S (Ali) : -0.07
Solubility : 95.0 mg/ml ; 0.848 mol/l
Class : Very soluble
Log S (SILICOS-IT) : 0.98
Solubility : 1080.0 mg/ml ; 9.62 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.5

Safety of [ 867-56-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:
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