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Chemical Structure| 85916-13-8 Chemical Structure| 85916-13-8
Chemical Structure| 85916-13-8

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CAS No.: 85916-13-8

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NH-bis(C1-Boc)is a uncleavable linker used for antibody-drug conjugates (ADC).

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Product Details of NH-bis(C1-Boc)

CAS No. :85916-13-8
Formula : C12H23NO4
M.W : 245.32
SMILES Code : O=C(OC(C)(C)C)CNCC(OC(C)(C)C)=O
MDL No. :MFCD01863672
InChI Key :SMXMBXPLRFTROI-UHFFFAOYSA-N
Pubchem ID :4393691

Safety of NH-bis(C1-Boc)

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of NH-bis(C1-Boc)

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 85916-13-8 ]

[ 85916-13-8 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 16644-30-7 ]
  • [ 85916-13-8 ]
  • [ 947323-53-7 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In tetrahydrofuran; for 4h;Heating / reflux; To a THF (8 ml) solution of di-tert-butyl iminodiacetate (504 mg, 2.1 mmol) and Et3N (0.54 ml, 3.9 mmol) was added a THF (2 ml) solution of <strong>[16644-30-7]3-chloromethyl-5-nitrosalicylaldehyde</strong> (435 mg, 2 mmol) dropwise at refluxing condition, and the reaction mixture was further refluxed for 4 h. After filtration, the reaction solvent was evaporated to afford V as a mixture with Et3N (10:7), which was used for the next reaction without purification. 1H NMR(CDCl3) delta1.50(s, 18H), 3.46(s, 4H), 4.07(s, 2H), 8.22(d, J=3.8 Hz, 1H), 8.65(d, J=3.8 Hz, 1H), 10.44 (s, 1H)
 

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