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Chemical Structure| 85141-94-2 Chemical Structure| 85141-94-2
Chemical Structure| 85141-94-2

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CAS No.: 85141-94-2

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Br-PEG4-OH is a 4-unit PEG derivative containing a bromine atom and a hydroxyl group. It is often used in drug delivery systems and in the preparation of reactive intermediates.

Synonyms: Br-PEG4-OH

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Product Citations

Product Citations

Cifone, Matthew T. ; He, YongLe ; Basu, Rajeswari ; Wang, Nan ; Davoodi, Shabnam ; Spagnuolo, Lauren A. , et al.

Abstract: The relationship between drug-target residence time and the post-antibiotic effect (PAE) provides insights into target vulnerability. To probe the vulnerability of bacterial acetyl-CoA carboxylase (ACC), a series of heterobivalent inhibitors were synthesized based on pyridopyrimidine 1 and moiramide B (3) which bind to the biotin carboxylase and carboxyltransferase ACC active sites, resp. The heterobivalent compound 17, which has a linker of 50 ?, was a tight binding inhibitor of Escherichia coli ACC (Kiapp 0.2 nM) and could be displaced from ACC by a combination of both 1 and 3 but not just by 1. In agreement with the prolonged occupancy of ACC resulting from forced proximity binding, the heterobivalent inhibitors produced a PAE in E. coli of 1-4 h in contrast to 1 and 3 in combination or alone, indicating that ACC is a vulnerable target and highlighting the utility of kinetic, time-dependent effects in the drug mechanism of action.

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Product Details of Br-PEG4-OH

CAS No. :85141-94-2
Formula : C8H17BrO4
M.W : 257.12
SMILES Code : BrCCOCCOCCOCCO
Synonyms :
Br-PEG4-OH
MDL No. :MFCD18205852
InChI Key :CERQCRALBKUCTF-UHFFFAOYSA-N
Pubchem ID :14786209

Safety of Br-PEG4-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501
 

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