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Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50 values of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively.
Synonyms: JNJ 28431754; TA-7284; JNJ-24831754
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Hasan, Ahasanul ; Zerin, Farzana ; Menon, Sreelakshmi N ; Alam, Md Ashraful ; Hasan, Raquibul ;
Abstract: Canagliflozin, a sodium glucose co-transporter 2 (SGLT2) inhibitor, is reported to produce beneficial cardiovascular effects including a reduction in arterial contractility, and blood pressure. However, whether canagliflozin could directly relax resistance mesenteric arteries, underlying molecular mechanism and its role in regulating systemic blood pressure remain unclear. Here, we investigated the mechanism of regulation of small mesenteric artery contractility and its relevance for blood pressure regulation. Our pressure myography data showed that canagliflozin application rapidly produces a concentration-dependent vasodilation in mesenteric arteries. Such vasodilation was inhibited by concurrent inhibition of smooth muscle cell voltage-gated Kt channels KV1.5 (by 1 mM DPO-1), KV2.1 (by 100 nM guangxitoxin), and KV7 (by 10 mM linopirdine) but not by the inhibition of small-, intermediate-, and large-conductance Ca2t-activated Kt channels (SKCa by 1 mM apamin, IKCa 10 mM TRAM-34, and BKCa by 10 mM paxilline, respectively), ATP-sensitive (KATP) channels (by 10 mM glibenclamide), or SERCA pump (by 0.1 mM thapsigargin). Inhibition of SGLTs (by 1 mM phlorizin or the inhibition of endothelial signaling did not alter canagliflozin-evoked vasodilation. Consistently, acute canagliflozin treatment (4 mg/kg body weight) lowered systemic blood pressure in vivo. Overall, our data suggests that canagliflozin stimulates KV1.5, KV2.1, and KV7 channels, leading to vasodilation and a reduction of systemic blood pressure.
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Keywords: Canagliflozin ; Mesenteric arteries ; Voltage-gated Kt channels ; Vasorelaxation ; Blood pressure
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CAS No. : | 842133-18-0 |
Formula : | C24H25FO5S |
M.W : | 444.52 |
SMILES Code : | FC1=CC=C(C2=CC=C(CC3=C(C=CC([C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3)C)S2)C=C1 |
Synonyms : |
JNJ 28431754; TA-7284; JNJ-24831754
|
MDL No. : | MFCD18251436 |
InChI Key : | XTNGUQKDFGDXSJ-ZXGKGEBGSA-N |
Pubchem ID : | 24812758 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H318-H361 |
Precautionary Statements: | P201-P202-P280-P281-P305+P351+P338-P308+P313-P310-P405-P501 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02053116 | Type 2 Diabetes Mellitus | Phase 2 | Terminated(On 25April2014, stu... More >>dy was terminated before any dosing due to an AE of safety concern that occurred in protocol B1731003 with the same drug.) Less << | - | United States, Florida ... More >> Pfizer Investigational Site DeLand, Florida, United States, 32720 Less << |
NCT00650806 | - | Completed | - | - | |
NCT01273558 | Diabetes Mellitus, Type 2 | PHASE1 | COMPLETED | 2025-07-11 | Neuss, Germany |
NCT01756404 | Healthy | Phase 1 | Completed | - | United States, Florida ... More >> Miramar, Florida, United States Less << |
NCT00650806 | Obesity | Phase 2 | Completed | - | - |
NCT02920918 | Heart Failure, Systolic ... More >> Diabetes Mellitus, Type 2 Less << | Phase 4 | Active, not recruiting | March 2019 | United States, Virginia ... More >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT02681497 | - | Completed | - | Canada, Ontario ... More >> Western University London, Ontario, Canada, N6A 3K7 Less << | |
NCT01714206 | Healthy | Phase 1 | Completed | - | - |
NCT01032629 | Diabetes Mellitus, Type 2 ... More >> Cardiovascular Diseases Risk Factors Less << | Phase 3 | Completed | - | - |
NCT01459094 | Healthy | Phase 1 | Completed | - | - |
NCT02737657 | - | Completed | - | Kuwait ... More >> Kuwait City, Kuwait Lebanon Amioun, Lebanon Beirut, Lebanon Nabatieh, Lebanon Saida, Lebanon Taalabya, Lebanon Tripoli, Lebanon United Arab Emirates Al Ain, United Arab Emirates Dubai, United Arab Emirates Less << | |
NCT02220907 | - | Completed | - | - | |
NCT02220907 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Research site Chubu, Japan Research site Chugoku, Japan Research site Hokkaido, Japan Research site Kanto, Japan Research site Kyushu, Japan Research site Tohoku, Japan Less << |
NCT01032629 | - | Completed | - | - | |
NCT01463774 | Healthy | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT02354222 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Reserch site Kanto, Japan Reserch site Kinki, Japan Reserch site Tohoku, Japan Less << |
NCT02354222 | - | Completed | - | - | |
NCT01665638 | Healthy | Phase 1 | Completed | - | Germany ... More >> Neuss, Germany Less << |
NCT02846506 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT02851212 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT02694263 | Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | September 2018 | United Kingdom ... More >> University Hospitals of Leicester NHS Trust Recruiting Leicester, Leicestershire, United Kingdom, LE5 4PW Contact: Emer Brady, PhD ?? 0116248 ext 8959 ?? emer.brady@uhl-tr.nhs.uk ?? Contact: Natasha Wileman, MSc ?? 0116258 ext 8929 ?? natasha.wileman@uhl-tr.nhs.uk ?? University Hospitals Birmingham NHS Foundation Trust Recruiting Birmingham, West Midlands, United Kingdom, B15 2TH Contact: Wasim Hanif ?? 0121371 ext 4404 ?? wasim.hanif@uhb.nhs.uk ?? Contact: Deborah Smith ?? 0121371 ext 4707 ?? deborah.smith@uhb.nhs.uk Less << |
NCT00968812 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT00968812 | - | Completed | - | - | |
NCT03267576 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | Mexico ... More >> Consultorio Privado Guadalajara, Mexico, 44150 Investigación Clínica Especializada Guadalajara, Mexico, 44600 Consultorio Privado en Unidad de Patología Clínica Guadalajara, Mexico, 44650 Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán Mexico City, Mexico, 14080 Hospital Universitario 'Dr. Jose Eleuterio Gonzalez' Monterrey, Mexico, 64460 Less << |
NCT01787357 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01916863 | Healthy Subjects | Phase 1 | Completed | - | United States, California ... More >> Lexicon Investigational Site Chula Vista, California, United States, 91911 Less << |
NCT01106677 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01748526 | Healthy | Phase 1 | Completed | - | India ... More >> Ahmedabad, India Less << |
NCT01759576 | Renal Insufficiency ... More >> Healthy Less << | Phase 1 | Completed | - | United States, Florida ... More >> Orlando, Florida, United States United States, Minnesota Minneapolis, Minnesota, United States United States, Tennessee Knoxville, Tennessee, United States Less << |
NCT01381887 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... More >> Chula Vista, California, United States United States, Florida Miramar, Florida, United States United States, Ohio Cincinnati, Ohio, United States United States, Texas Dallas, Texas, United States San Antonio, Texas, United States Less << |
NCT02851095 | Healthy | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT02865668 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01106690 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02220920 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Japan ... More >> Reserch site Chubu, Japan Reserch site Chugoku, Japan Reserch site Hokkaido, Japan Reserch site Kanto, Japan Reserch site Kinki, Japan Reserch site Kyushu, Japan Reserch site Tohoku, Japan Less << |
NCT02220920 | - | Completed | - | - | |
NCT02360774 | - | Completed | - | - | |
NCT01821027 | Healthy | Phase 1 | Completed | - | - |
NCT01483781 | Diabetes Mellitus, Type 2 ... More >> Plasma Volume Less << | Phase 1 | Completed | - | Germany ... More >> Neuss, Germany Less << |
NCT01106677 | - | Completed | - | - | |
NCT01137812 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01137812 | - | Completed | - | - | |
NCT03136484 | Diabetes Diab... More >>etes Mellitus, Type 2 Less << | Phase 3 | Completed | - | - |
NCT02025907 | - | Completed | - | - | |
NCT01106690 | - | Completed | - | - | |
NCT02025907 | Diabetes Mellitus, Type 2 | Phase 4 | Completed | - | - |
NCT01106625 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT02360774 | Type 2 Diabetes ... More >> Overweight Obesity Less << | Phase 4 | Completed | - | United States, Massachusetts ... More >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Less << |
NCT01173549 | Healthy | Phase 1 | Completed | - | United States, California ... More >> La Jolla, California, United States Less << |
NCT01106625 | - | Completed | - | - | |
NCT02462421 | Diabetes Mellitus|Gout|Hyperur... More >>icemia Less << | PHASE4 | TERMINATED | 2021-12-31 | - |
NCT01508182 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01508195 | Healthy | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT01756417 | Healthy | Phase 1 | Completed | - | United States, New Jersey ... More >> Neptune, New Jersey, United States Less << |
NCT02009488 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, California ... More >> San Diego, La Jolla, California, United States United States, Florida Gainesville, Florida, United States Less << |
NCT02039258 | Healthy Volunteers | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT01106651 | - | Completed | - | - | |
NCT01106651 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01081834 | - | Completed | - | - | |
NCT01939496 | - | Completed | - | - | |
NCT01989754 | Diabetes Mellitus, Type 2 ... More >> Albuminuria Less << | Phase 4 | Completed | - | - |
NCT01939496 | Diabetes Mellitus, Type 2 ... More >> Hypertension Less << | Phase 4 | Completed | - | - |
NCT01733108 | Healthy | Phase 1 | Completed | - | - |
NCT01081834 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01809327 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | - |
NCT01989754 | - | Completed | - | - | |
NCT02077803 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT02354235 | - | Completed | - | - | |
NCT02354235 | Type 2 Diabetes Mellitus | Phase 3 | Completed | - | Japan ... More >> Reserch site Kanto, Japan Reserch site Kinki, Japan Reserch site Tohoku, Japan Less << |
NCT02071368 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01281579 | Healthy | Phase 1 | Completed | - | - |
NCT01381900 | Diabetes Mellitus, Type 2 | Phase 3 | Completed | - | China ... More >> Baotou, China Beijing, China Changchun, China Changsha, China Chengdu, China Chongqing, China Guangzhou, China Hangzhou, China Harbin, China Nanchang, China Nanjing, China Nanning, China Shanghai, China Shenyang, China Shiyan, China Siping, China Su Zhou, China Tianjin, China Wuxi, China Xi'An, China Malaysia Kota Bharu, Malaysia Pulau Pinang, Malaysia Selangor, Malaysia Vietnam Hanoi, Vietnam Ho Chi Minh, Vietnam Less << |
NCT01809327 | - | Completed | - | - | |
NCT02065791 | Diabetes Mellitus, Type 2 ... More >> Diabetic Nephropathy Less << | Phase 3 | Active, not recruiting | June 28, 2019 | - |
NCT01381900 | - | Completed | - | - | |
NCT01463228 | Healthy | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT01454622 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT02404870 | Diabetes PTH ... More >> Vitamin D Fibroblast Growth Factor (FGF23) Phosphate Less << | Phase 1 | Recruiting | May 1, 2019 | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) ?? 800-411-1222 ext TTY8664111010 ?? prpl@cc.nih.gov Less << |
NCT01195324 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Merksem, Belgium Less << |
NCT01791231 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Merksem, Belgium Less << |
NCT01286103 | Healthy | Phase 1 | Completed | - | - |
NCT01128985 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, Florida ... More >> Fort Myers, Florida, United States Miramar, Florida, United States Less << |
NCT02065752 | Healthy Volunteers | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT02227849 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Japan ... More >> Reserch site Chubu, Japan Reserch site Hokkaido, Japan Reserch site Kanto, Japan Reserch site Kinki, Japan Less << |
NCT01340664 | Diabetes Mellitus, Type 2 | Phase 2 | Completed | - | - |
NCT01518712 | Healthy | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01340664 | - | Completed | - | - | |
NCT02622113 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Japan ... More >> Reserch site Chubu, Japan Reserch site Chugoku, Japan Reserch site Hokkaido, Japan Reserch site Kanto, Japan Reserch site Kinki, Japan Reserch site Kyushu, Japan Reserch site Tohoku, Japan Less << |
NCT02688075 | - | Completed | - | Canada, Alberta ... More >> Calgary, Alberta, Canada Edmonton, Alberta, Canada Canada, British Columbia Coquitlam, British Columbia, Canada Surrey, British Columbia, Canada Canada, Manitoba Winnipeg, Manitoba, Canada Canada, Ontario Brampton, Ontario, Canada Downsview, Ontario, Canada Guelph, Ontario, Canada London, Ontario, Canada Mississauga, Ontario, Canada Ohsweken, Ontario, Canada Ottawa, Ontario, Canada Smiths Falls, Ontario, Canada Toronto, Ontario, Canada Canada, Quebec Laval, Quebec, Canada Longueuil, Quebec, Canada Montreal, Quebec, Canada Saint-Jean-Sur-Richelieu, Quebec, Canada Sherbrooke, Quebec, Canada St Marc Des Carrieres, Quebec, Canada Toronto, Quebec, Canada Westmont, Quebec, Canada Canada, Saskatchewan Saskatoon, Saskatchewan, Canada Less << | |
NCT02039245 | Healthy Volunteers | Phase 1 | Completed | - | United States, New Jersey ... More >> Neptune, New Jersey, United States Less << |
NCT01064414 | Diabetes Mellitus, Type 2 ... More >> Renal Insufficiency Less << | Phase 3 | Completed | - | - |
NCT01294631 | Healthy | Phase 1 | Completed | - | - |
NCT01395927 | Healthy | Phase 1 | Completed | - | United States, Kansas ... More >> Overland Park, Kansas, United States Less << |
NCT01340677 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Merksem, Belgium Less << |
NCT01064414 | - | Completed | - | - | |
NCT01714193 | Healthy | Phase 1 | Completed | - | - |
NCT03170518 | Diabetes Mellitus, Type 2 | Phase 3 | Recruiting | June 30, 2021 | - |
NCT01273571 | Healthy | Phase 1 | Completed | - | - |
NCT01343290 | Healthy | PHASE1 | COMPLETED | 2025-06-11 | - |
NCT02243202 | Obesity | Phase 2 | Completed | - | United States, Arizona ... More >> Phoenix, Arizona, United States United States, California Walnut Creek, California, United States United States, Florida Jacksonville, Florida, United States United States, Idaho Meridian, Idaho, United States United States, Indiana Evansville, Indiana, United States United States, Kentucky Lexington, Kentucky, United States Louisville, Kentucky, United States United States, Louisiana New Orleans, Louisiana, United States United States, Massachusetts Milford, Massachusetts, United States United States, New York Manlius, New York, United States United States, Rhode Island Warwick, Rhode Island, United States United States, South Carolina Mt Pleasant, South Carolina, United States United States, Tennessee Nashville, Tennessee, United States United States, Texas Dallas, Texas, United States Odessa, Texas, United States United States, Virginia Norfolk, Virginia, United States United States, Wisconsin Wauwatosa, Wisconsin, United States Less << |
NCT02139943 | - | Completed | - | - | |
NCT02964585 | Type 2 Diabetes Mellitus | Phase 4 | Recruiting | May 2019 | United States, District of Col... More >>umbia The George Washington University Medical Faculty Associates Recruiting Washington, District of Columbia, United States, 20037 Contact: Fiona Dore, BS ?? 202-741-2342 ?? fdore@mfa.gwu.edu Less << |
NCT02221180 | Bioequivalence | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT03298009 | Type2 Diabetes ... More >> Heart Failure Less << | Not Applicable | Withdrawn(end of contract nego... More >>ciations) Less << | January 1, 2019 | - |
NCT02139943 | Diabetes Mellitus, Type 1 | Phase 2 | Completed | - | - |
NCT01428284 | Healthy | Phase 1 | Completed | - | United States, Kansas ... More >> Overland Park, Kansas, United States Less << |
NCT02073227 | Healthy Volunteers | Phase 1 | Completed | - | United States, Arizona ... More >> Tempe, Arizona, United States Less << |
NCT01707316 | Healthy | Phase 1 | Completed | - | China ... More >> Beijing, China Less << |
NCT02243202 | - | Completed | - | - | |
NCT03436693 | Diabetic Nephropathy | Phase 3 | Recruiting | September 2021 | Japan ... More >> Research site Recruiting Aichi, Japan Research site Recruiting Chiba, Japan Research site Recruiting Fukuoka, Japan Research site Recruiting Fukushima, Japan Research site Recruiting Gunma, Japan Research site Recruiting Hiroshima, Japan Research site Recruiting Hokkaido, Japan Research site Recruiting Hyogo, Japan Research site Recruiting Ibaraki, Japan Research site Recruiting Kagawa, Japan Research site Recruiting Kagoshima, Japan Research site Recruiting Kanagawa, Japan Research site Recruiting Kumamoto, Japan Research site Recruiting Mie, Japan Research site Recruiting Nagano, Japan Research site Recruiting Nagasaki, Japan Research site Recruiting Oita, Japan Research site Recruiting Okinawa, Japan Research site Recruiting Osaka, Japan Research site Recruiting Saitama, Japan Research site Recruiting Shizuoka, Japan Research site Recruiting Tochigi, Japan Research site Recruiting Tokyo, Japan Research site Recruiting Wakayama, Japan Research site Recruiting Yamagata, Japan Research site Recruiting Yamaguchi, Japan Less << |
NCT02220218 | Healthy | Phase 1 | Completed | - | United States, Nebraska ... More >> Lincoln, Nebraska, United States Less << |
NCT02597309 | Diabetes, Obesity | PHASE4 | WITHDRAWN | 2025-07-17 | Joslin Diabetes Center, Boston... More >>, Massachusetts, 02215, United States Less << |
NCT02324842 | Type 2 Diabetes Mellitus | Not Applicable | Recruiting | December 2018 | United States, Texas ... More >> University of Texas Health Science Center at San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Ralph A DeFronzo, MD ?? 210-567-6691 ?? defronzo@uthscsa.edu ?? Contact: Monica Palomo, BS ?? 210-567-6710 ?? palomom@uthscsa.edu ?? Principal Investigator: Ralph A DeFronzo, MD Less << |
NCT01186588 | Healthy|Hepatic Insufficiency | PHASE1 | COMPLETED | 2025-04-11 | Orlando, Florida, United State... More >>s|Knoxville, Tennessee, United States Less << |
NCT01877889 | Healthy | Phase 1 | Completed | - | Germany ... More >> Neuss, Germany Less << |
NCT03604224 | - | Recruiting | March 29, 2019 | India ... More >> Diacon Hospital Recruiting Bangalore, India, 560010 Dr. A. Ramachandran's Diabetes Hospitals Not yet recruiting Chennai, India, 600032 CARE Hospitals Not yet recruiting Hydrabad, India, 500001 Less << | |
NCT02624908 | Diabetes Mellitus, Type 2 | Phase 4 | Recruiting | November 2018 | United States, Georgia ... More >> Atlanta VA Medical Center Recruiting Decatur, Georgia, United States, 30033 Less << |
NCT01718652 | Healthy | Phase 1 | Completed | - | Belgium ... More >> Antwerpen, Belgium Less << |
NCT03190798 | Type2 Diabetes Mellitus ... More >> Cardiovascular Diseases Less << | Phase 4 | Withdrawn(Study has been withd... More >>rawn from IRB review pending IND revision) Less << | August 1, 2018 | United States, Texas ... More >> The University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 Less << |
NCT02891954 | Diabetes Mellitus, Type 2 | PHASE1 | ACTIVE_NOT_RECRUITING | 2025-09-25 | - |
NCT02673138 | Type 1 Diabetes | Not Applicable | Completed | - | United States, Connecticut ... More >> Yale University School of Medicine New Haven, Connecticut, United States, 06520 Less << |
NCT02673138 | - | Completed | - | - | |
NCT02000700 | Diabetes Mellitus, Type 2 | Phase 1 | Completed | - | United States, Arkansas ... More >> Little Rock, Arkansas, United States United States, California Los Angeles, California, United States United States, Colorado Aurora, Colorado, United States United States, Connecticut New Haven, Connecticut, United States United States, Florida Jacksonville, Florida, United States United States, Indiana Indianapolis, Indiana, United States United States, Kansas Lenexa, Kansas, United States United States, Maryland Baltimore, Maryland, United States United States, Missouri Kansas City, Missouri, United States United States, Ohio Toledo, Ohio, United States United States, Pennsylvania Pittsburgh, Pennsylvania, United States United States, Texas Houston, Texas, United States United States, Utah Salt Lake City, Utah, United States Brazil Campinas, Brazil Curitiba, Brazil Ribeir?o Preto, Brazil Sao Paulo, Brazil Less << |
NCT01157000 | Healthy | PHASE1 | COMPLETED | 2025-06-10 | Merksem, Belgium |
NCT02912455 | Diabetes Mellitus, Type 2 ... More >> Obesity Less << | Phase 4 | Recruiting | July 31, 2018 | United States, Ohio ... More >> Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Sangeeta Kashyap, MD ?? 216-445-2679 ?? kashyas@ccf.org ?? Contact: Mario Scarcipino ?? 216-444-3599 ?? mascar@ccf.org ?? Principal Investigator: Sangeeta Kashyap, MD Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.22mL |
11.25mL 2.25mL 1.12mL |
22.50mL 4.50mL 2.25mL |