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Chemical Structure| 816-94-4 Chemical Structure| 816-94-4

Structure of 816-94-4

Chemical Structure| 816-94-4

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CAS No.: 816-94-4

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1,2-DSPC is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions, which is commonly used in the generation of liposomes.

Synonyms: 1,2-Distearoyl-sn-glycero-3-PC; DSPC; Coatsome MC 8080

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Product Citations

Product Citations

Xuexiang Han ; Junchao Xu ; Ying Xu ; Mohamad-Gabriel Alameh ; Lulu Xue ; Ningqiang Gong , et al.

Abstract: The ionizable lipidoid is a key component of nanoparticles (LNPs). Degradable lipidoids containing extended alkyl branches have received tremendous attention, yet their optimization and investigation are underappreciated. Here, we devise an in situ construction method for the combinatorial synthesis of degradable branched (DB) lipidoids. We find that appending branch tails to inefficacious lipidoids via degradable linkers boosts mRNA delivery efficiency up to three orders of magnitude. Combinatorial screening and systematic investigation of two libraries of DB-lipidoids reveal important structural criteria that govern their in vivo potency. The DB-LNP demonstrates robust delivery of mRNA therapeutics and gene editors into the liver. In a diet-induced obese mouse model, we show that repeated administration of DB-LNP encapsulating mRNA encoding human fibroblast growth factor 21 alleviates obesity and fatty liver. Together, we offer a construction strategy for high-throughput and cost-efficient synthesis of DB-lipidoids. This study provides insights into branched lipidoids for efficient mRNA delivery.

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Product Details of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine

CAS No. :816-94-4
Formula : C44H88NO8P
M.W : 790.15
SMILES Code : O=P(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)([O-])OCC[N+](C)(C)C
Synonyms :
1,2-Distearoyl-sn-glycero-3-PC; DSPC; Coatsome MC 8080
InChI Key :NRJAVPSFFCBXDT-HUESYALOSA-N
Pubchem ID :94190

Safety of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.33mL

1.27mL

0.63mL

12.66mL

2.53mL

1.27mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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