成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 78415-72-2 Chemical Structure| 78415-72-2

Structure of Milrinone
CAS No.: 78415-72-2

Chemical Structure| 78415-72-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

{[proInfo.proName]}

CAS No.: 78415-72-2

,{[proInfo.pro_purity]}

Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.

Synonyms: Win 47203; WIN 47,203; Milrinone, Primacor, Corotrop, Milrila, Win-47203

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Milrinone

CAS No. :78415-72-2
Formula : C12H9N3O
M.W : 211.22
SMILES Code : N#CC1=CC(C2=CC=NC=C2)=C(C)NC1=O
Synonyms :
Win 47203; WIN 47,203; Milrinone, Primacor, Corotrop, Milrila, Win-47203
MDL No. :MFCD00133539
InChI Key :PZRHRDRVRGEVNW-UHFFFAOYSA-N
Pubchem ID :4197

Safety of Milrinone

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:Ⅲ

Isoform Comparison

Biological Activity

Target

  • PDE2

    PDE2, IC50:5.2 μM

  • PDE3

    PDE3, IC50:2.1 μM

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse denuded oocytes 1.0 μM Inhibition of oocyte maturation PMC508914
Mouse oocytes 1 μM 2 hours Maintain germinal vesicle stage arrest PMC5716262
HEK-TSHR cells 1.0 mM Milrinone, as a PDE3-specific inhibitor, exposed persistent TSHR-mediated cAMP signaling PMC3822400
Murine tracheal epithelial cells 13.7 μM 80 minutes To evaluate the effect of Milrinone on ciliary transport velocity in murine tracheal epithelial cells, results showed that Milrinone increased PTV in a dose-dependent manner with an EC50 of 13.7 μM. PMC11816908
Adult mouse cardiomyocytes 30 μM 24 hours To evaluate the effect of milrinone on hypoxia/reoxygenation or H2O2-induced cardiomyocyte apoptosis. Results showed that milrinone treatment significantly increased the apoptotic rate in both WT and TG cardiomyocytes. PMC3869570
HT22CREluc cells 100 μM ~11 hours To investigate the effect of the PDE3-selective inhibitor milrinone on CRE-dependent transcriptional activity, results showed milrinone was effective at higher concentrations but two orders of magnitude less efficient than IBMX and rolipram. PMC7696530

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice DF508 mutant mice Nasal perfusion 100 μM Single administration, lasting 4.5 minutes To evaluate the effect of milrinone and forskolin combination on the potential difference across nasal epithelium in DF508 mutant mice. Results showed that the combination significantly increased the potential difference, indicating partial restoration of CFTR-mediated electrolyte transport. PMC20135
Mice HDM-driven allergic airway inflammation model Intratracheal administration 10 μg 5 consecutive days Study the effect of milrinone on allergic airway inflammation PMC5821178
Male ddY mice LPS-induced microvascular permeability change model Intraperitoneal injection 5 – 10 mg/kg Single dose, lasting 2 hours Milrinone significantly inhibited LPS-induced dye leakage and elevation of serum TNF-α levels PMC1572781
Mice Murine tracheal model Intratracheal administration 13.7 μM Single administration, lasting 80 minutes To evaluate the effect of Milrinone on ciliary transport velocity in murine tracheae, results showed that Milrinone increased PTV via Ca2+ release from intracellular stores and depended on both PKA and PLC pathways. PMC11816908
Mice Transgenic mice with myocardial overexpression of PDE3A1 Intraperitoneal injection 10 mg/kg Single dose To evaluate the effect of milrinone on cardiac contractile function and heart rate. Results showed that milrinone treatment significantly attenuated the differences in cardiac contractile function and heart rate between TG and WT mice under ISO stimulation. PMC3869570

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02606253 Heart Failure Phase 4 Active, not recruiting October 31, 2018 United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37204 Less <<
NCT02884011 - Completed - United States, Illinois ... More >> Rush Univeristy Medical Center Chicago, Illinois, United States, 60612 Less <<
NCT02261506 Bacteremia Not Applicable Completed - Canada, Alberta ... More >> Foothills Hospital Calgary, Alberta, Canada University of Alberta Hospital Edmonton, Alberta, Canada Canada, British Columbia Royal Columbian Hospital Vancouver, British Columbia, Canada St. Paul's Hospital Vancouver, British Columbia, Canada Canada, Manitoba St. Boniface Hospital Winnipeg, Manitoba, Canada Canada, Nova Scotia Queen Elizabeth II Hospital Halifax, Nova Scotia, Canada Canada, Ontario Kingston General Hospital Kingston, Ontario, Canada London Health Sciences Centre London, Ontario, Canada The Ottawa Hospital Ottawa, Ontario, Canada Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Mount Sinai Hospital Toronto, Ontario, Canada St. Michael's Hospital Toronto, Ontario, Canada Toronto Western Hospital Toronto, Ontario, Canada Canada, Quebec CHUM Montreal, Quebec, Canada Université de Sherbrooke Sherbrooke, Quebec, Canada Canada Centre hospitalier affilié universitaire de Québec Quebec, Canada CSSS de Trois-Rivières Quebec, Canada Less <<
NCT01364636 - Terminated(problems with the s... More >>tability of samples collected) Less << - Brazil ... More >> Hospital Universitário Antonio Pedro Rio de Janeiro, RJ, Brazil, 22280-000 Less <<
NCT02836899 Acute Kidney Injury Phase 3 Recruiting December 31, 2021 United States, Massachusetts ... More >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Lorenzo Berra, MD ?? 617-643-7733 ?? lberra@mgh.harvard.edu Less <<
NCT02681913 Pathological Processes ... More >> Cardiomyopathies Less << Phase 2 Recruiting December 2018 Netherlands ... More >> Amphia Hospital Recruiting Breda, Noord-Brabant, Netherlands, 4818CK Contact: Jeffrey Engelhart, PharmD ?? 0031765954391 ?? jengelhart@amphia.nl ?? Contact: Thierry Scohy, MD ?? 0031765955570 ?? tscohy@amphia.nl Less <<
NCT03335865 - Recruiting December 1, 2018 United States, Utah ... More >> University of Utah Recruiting Salt Lake City, Utah, United States, 84112 Contact: Ami Stuart, PhD ?? 801-793-4800 ?? ami.stuart@hsc.utah.edu Less <<
NCT03574311 Coronary Artery Disease ... More >> Postoperative Complications Less << Phase 4 Recruiting December 2020 Finland ... More >> Turku University Hospital Recruiting Turku, Finland, 20521 Contact: Jarmo M Gunn, PhD ?? +35823130548 ?? jarmo.gunn@tyks.fi ?? Contact: Tuija Vasankari, RN ?? +35823130000 ?? tuija.vasankari@tyks.fi Less <<
NCT02043379 Hypogammaglobulinemia ... More >> Congenital Heart Disease Less << Not Applicable Completed - United States, Alabama ... More >> Children's of Alabama Birmingham, Alabama, United States, 35233 Less <<
NCT03071835 - Enrolling by invitation December 31, 2029 United States, Florida ... More >> ISCI / University of Miami Miller School of Medicine Miami, Florida, United States, 33136 Less <<
NCT01595386 Heart Disease Congenital Compl... More >>ex Less << Not Applicable Completed - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 Less <<
NCT03060018 Critical Illness Not Applicable Recruiting July 31, 2019 Switzerland ... More >> University Children's Hospital Zurich Recruiting Zürich, Switzerland, 8032 Contact: Philipp Baumann, MD ?? 0041442667076 ?? philipp.baumann@kispi.uzh.ch ?? Contact: Vera Bernet, MD ?? 0041442667111 ?? vera.bernet@kispi.uzh.ch Less <<
NCT02043379 - Completed - -
NCT01864252 Myocardial Reperfusion Injury Phase 3 Unknown February 2016 United Kingdom ... More >> The Heart Hospital, UCL Hospitals NHS Trust Recruiting London, United Kingdom, NW1 2PG Contact: Ashraf Hamarneh, MBchB,MRCP ?? 02034479781 ?? a.hamarneh@ucl.ac.uk ?? Principal Investigator: Derek M Yellon, PhD DSc FACC ?? ?? ?? Principal Investigator: Derek J Hausenloy, MD PhD FRCP ?? ?? ?? Sub-Investigator: Ashraf Hamarneh, MBchB MRCP ?? ?? ?? Sub-Investigator: Shyam Kolvekar, MS MCh FRCS ?? ?? ?? Sub-Investigator: Roger Cordery, BSc FRCA ?? ?? ?? Sub-Investigator: Vivek Sivaraman, MRCP MD FRCA Less <<
NCT01688648 Unstable Angina ... More >> Coronary Artery Bypass Graft Dexmedetomidine Lidocaine Myocardial Injury Arrhythmia Blood Electrolyte Balance Less << Not Applicable Completed - Korea, Republic of ... More >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 Less <<
NCT01681095 Coronary Artery Disease ... More >> Myocardial Ischemia Coronary Disease Heart Diseases Valvular Heart Disease Less << Phase 2 Completed - United States, Michigan ... More >> William Beaumont Hospital Royal Oak, Michigan, United States, 48073 Less <<
NCT02908009 - Recruiting July 2018 United Kingdom ... More >> England Recruiting Glenfield, Leicestershire, United Kingdom, LE3 9QP Less <<
NCT03082716 Congenital Heart Disease Phase 2 Recruiting January 20, 2019 Saudi Arabia ... More >> King Faisal Specialist Hospital and Research Centre Recruiting Jeddah, Western, Saudi Arabia, 40047 Contact: Bayan Alshaikh, MBBS ?? 00966502088088 ?? b_al-shaikh@hotmail.com Less <<
NCT01316497 Acute Kidney Injury Not Applicable Completed - Denmark ... More >> Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby Aarhus, Denmark, 8200 Less <<
NCT01595386 - Completed - -
NCT02025621 Coronary Artery Bypass Graftin... More >>g Mitral Valve Surgery Low Cardiac Output Syndrome Less << Phase 3 Completed - -
NCT02025621 - Completed - -
NCT03500783 Coronary Artery Disease ... More >> Coronary Artery Bypass Cardiopulmonary Bypass Nitric Oxide Reperfusion Injury, Myocardial Less << Phase 1 Phase 2 Completed - -
NCT02726620 Hypotension Not Applicable Active, not recruiting December 31, 2018 United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37212 Less <<
NCT03469440 Heart; Dysfunction Postoperati... More >>ve, Cardiac Surgery C.Surgical Procedure; Cardiac Less << Not Applicable Recruiting June 2018 Brazil ... More >> Incor - Heart Institute - University of Sao Paulo Recruiting Sao Paulo, Brazil, 05403000 Contact: Filomena RG Galas ?? +551126615232 ?? filomenagalas@hotmail.com Less <<
NCT01996436 Cerebral Vasospasm Phase 4 Recruiting December 2020 United States, Connecticut ... More >> Yale School of Medicine Recruiting New Haven, Connecticut, United States, 06520 Contact: Nils Petersen, MD ?? ?? nils.petersen@yale.edu ?? Principal Investigator: Nils Petersen, MD ?? ?? ?? United States, Illinois University of Illinois College of Medicine at Chicago Recruiting Chicago, Illinois, United States, 60612 Contact: Ali Alaraj, MD ?? 312-996-4842 ?? alaraj@uic.edu ?? Principal Investigator: Ali Alaraj, MD ?? ?? ?? United States, Michigan University of Michigan Not yet recruiting Ann Arbor, Michigan, United States, 48109 Contact: Aditya Pandey, MD ?? 734-615-4486 ?? adityap@med.umich.edu ?? United States, New York Northwell Health Not yet recruiting Manhasset, New York, United States, 11030 Contact: David Ledoux, MD ?? 516-562-3590 ?? ?? Lenox Hill Not yet recruiting New York, New York, United States, 10065 Contact: David Ledoux, MD ?? ?? ?? United States, North Carolina Wake Forest University Health Sciences Recruiting Winston-Salem, North Carolina, United States, 27157 Contact: Stacey Wolfe, MD ?? 336-716-3842 ?? sqwolfe@wakehealth.edu ?? Contact: Wendy Jenkins ?? 336.716.3842 ?? mailto:wejenkin@wakehealth.edu ?? United States, Pennsylvania Geisinger Clinic Recruiting Danville, Pennsylvania, United States, 17822 Contact: Clemens Schirmer, MD ?? ?? ?? Contact: Tejal Raichura ?? 570.214.6084 ?? taraichura@geisinger.edu ?? Thomas Jefferson University Not yet recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Pascal M Jabbour, MD ?? 215-955-7000 ?? Pascal.Jabbour@jefferson.edu ?? Principal Investigator: Pascal M Jabbour, MD ?? ?? ?? Temple University Recruiting Philadelphia, Pennsylvania, United States, 19140 Contact: Kadir Erkmen, MD ?? 617-697-4722 ?? Kadir.Erkmen@tuhs.temple.edu ?? Contact: Kathleen Hatala ?? ?? Kathleen.Hatala@tuhs.temple.edu ?? United States, Texas University of Texas Medical School at Houston Recruiting Houston, Texas, United States, 77030 Contact: Sunil Sheth, MD ?? ?? Sunil.A.Sheth@uth.tmc.edu ?? Contact: Aditya A Sanzgiri, MBBS MPH ?? 713-704-7263 ?? Aditya.A.Sanzgiri@uth.tmc.edu ?? Principal Investigator: Sunil Sheth, MD Less <<
NCT02891837 Acute Lung Injury Phase 3 Recruiting October 2019 -
NCT02287753 Congenital Heart Disease Not Applicable Completed - Korea, Republic of ... More >> Seoul national university hospital Seoul, Korea, Republic of Less <<
NCT01681095 - Completed - -
NCT01301313 Acute Heart Failure Phase 2 Terminated - Spain ... More >> Hospital Donosti Donostia, San Sebastian, Spain Hospital Clínico Universitario de Santiago de Compostela A Coru?a, Spain Hospital Juan Canalejo A Coru?a, Spain Hospital San Joan de Deu Barcelona, Spain Hospital Universitario Reina Sofía Córdoba, Spain Hospital Universitario Ramon y Cajal Madrid, Spain, 28034 Hospital General Universitario Gregorio Mara?ón Madrid, Spain Hospital Infantil La Paz Madrid, Spain Hospital Universitario Doce de Octubre Madrid, Spain Hospital Universitario Carlos Haya Malaga, Spain Hospital Virgen de la Arrixaca Murcia, Spain Hospital Clínico Universitario Son Dureta Palma de Mallorca, Spain Complejo Hospitalario Universitario de Salamanca Salamanca, Spain Hospital Virgen de la Salud Toledo, Spain Hospital Clínico de Valencia Valencia, Spain Hospital La Fe Valencia, Spain Hospital Clínico Universitario de Valladolid Valladolid, Spain Hospital de Cruces Vizcaya, Spain Hospital Miguel Servet Zaragoza, Spain Less <<
NCT03180450 Heart Failure Phase 1 Phase 2 Not yet recruiting January 2019 China, Inner Mongolia ... More >> Inner Mongolia International Mongolian Hospital Not yet recruiting Hohhot, Inner Mongolia, China, 010065 Contact: Bahushan ?? 864715182094 ?? bahushan@163.com Less <<
NCT00590018 Cardiac Output, Low Phase 2 Completed - United States, Texas ... More >> Texas Children's Hospital Houston, Texas, United States, 77030 Less <<
NCT01800877 Hypotension S... More >>hock Less << Not Applicable Completed - United States, Missouri ... More >> Mercy Hospital St. Louis, Missouri, United States Canada, Alberta University of Alberta Hospital Edmonton, Alberta, Canada Canada, Nova Scotia Queens Elizabeth II Hospital Halifax, Nova Scotia, Canada Canada, Ontario Kingston General Hospital Kingston, Ontario, Canada, K7L 2V7 The Ottawa Hospital Ottawa, Ontario, Canada Mt Sinai Hospital Toronto, Ontario, Canada, M5G 1X5 Sunnybrooke HSC Toronto, Ontario, Canada Toronto General Hospital Toronto, Ontario, Canada Canada, Quebec Hopital L'Enfant-Jesus Quebec City, Quebec, Canada Centre Hospitalier Universitaire de Sherbrooke Sherbrooke, Quebec, Canada, J1H 5N4 Less <<
NCT03631654 Heart Failure NYHA Class IV Phase 4 Not yet recruiting August 31, 2021 -
NCT01120106 Low Cardiac Output Syndrome Phase 2 Completed - Italy ... More >> Bambino Gesù Hospital Rome, Italy, 00165 Less <<
NCT00590018 - Completed - -
NCT01500785 Myocardial Stunning Phase 4 Suspended(Change of schedule) September 15, 2018 Finland ... More >> Heart Center Co. Tampere university hospital Tampere, Finland, 33521 Less <<
NCT02806245 Congenital Heart Disease (CHD) Not Applicable Completed - Canada, Ontario ... More >> Hospital for Sick Children Toronto, Ontario, Canada, M5G1X8 Less <<
NCT00060840 - Completed - -
NCT00060840 Congestive Heart Failure Phase 2 Completed - United States, New Jersey ... More >> Newark Beth Isreal Medical Center Newark, New Jersey, United States, 07112 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45219 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania Allegheny General Hospital Pittsburgh, Pennsylvania, United States, 15212 United States, Texas Baylor University Medical Center Dallas, Texas, United States, 75226 University of Texas/St. Paul Medical Center Dallas, Texas, United States, 75390 Texas Heart Institute Houston, Texas, United States, 20345 Germany Herz-und Diabeteszentrum Nordrhein-Westfalen Gergstrab, Bad Oeynhausen, Germany, 32545 Deutsches Herfzzentrum Berlin Augustenburger Platz, Berlin, Germany, 13353 United Kingdom Harefield Hospital Harefield, Middlesex, United Kingdom, UB96JH Less <<
NCT01616069 Cardiopulmonary Bypass Graft Phase 4 Completed - Brazil ... More >> National Institute of Cardiology / Ministry of Health Rio de janeiro, RJ, Brazil, 3600-100 Less <<
NCT02730117 Acute Kidney Injury Not Applicable Completed - Thailand ... More >> Sasipha Tachaboon Bangkok, Pathumwan, Thailand, 10330 Less <<
NCT02644824 Congenital Heart Disease (CHD) Not Applicable Completed - Canada, Ontario ... More >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Less <<
NCT03659851 - Recruiting December 31, 2018 Croatia ... More >> Nikola Bradic Recruiting Zagreb, Croatia, 10000 Contact: Nikola Bradic, MD ?? +385 91 589 3480 ?? nbradic@kbd.hr Less <<
NCT01940250 Hand, Foot and Mouth Disease Phase 2 Completed - Vietnam ... More >> Children's Hospital 1 Ho Chi Minh City, Vietnam Hospital for Tropical Diseases Ho CHi Minh City, Vietnam Less <<
NCT02033967 CVP and SVV During Living Dono... More >>r Hepatectomy Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC) Less << Not Applicable Completed - Korea, Republic of ... More >> Seoul national University Hospital Seoul, Korea, Republic of, 110-744 Less <<
NCT01971944 - Completed - United States, North Carolina ... More >> UNC Healthcare Chapel Hill, North Carolina, United States, 27599 Less <<
NCT03160846 - Recruiting August 2020 United States, Illinois ... More >> Northwestern University, Bluhm Cardiovascular Institute Recruiting Chicago, Illinois, United States, 60611 Contact: Catherine Crooke, MArch, CCRC ?? 312-695-4189 ?? ccrooke@nm.org ?? Principal Investigator: Jonathan Rich, MD ?? ?? ?? United States, New York Columbia University Medical Center/Vivian and Seymour Milstein Family Heart Center Recruiting New York, New York, United States, 10032 Contact: Danielle L. Brunjes, PhD ?? ?? dlt2127@columbia.edu ?? Principal Investigator: Maryjane A Farr, MD ?? ?? ?? United States, Wisconsin Aurora St. Luke's Medical Center, Tendick Center for Advanced Heart Failure Therapies Recruiting Milwaukee, Wisconsin, United States, 53215 Contact: Marilyn Miller, RN, CCRC ?? 414-385-2432 ?? marilyn.l.miller@aurora.org ?? Principal Investigator: Vinay Thohan, MD Less <<
NCT00695929 Congenital Cardiovascular Defe... More >>cts Low Cardiac Output Syndrome Less << Not Applicable Completed - Belgium ... More >> Cliniques Universitaires Saint Luc Brussels, Belgium, 1200 Less <<
NCT00338455 - Terminated(DSMC acknowledged n... More >>o safety concerns with the trial, recommending that the trial be terminated due to slow enrollment) Less << - -
NCT00338455 Congestive Heart Failure ... More >> Cardiac Transplantation Renal Insufficiency Renal Failure Less << Phase 2 Terminated(DSMC acknowledged n... More >>o safety concerns with the trial, recommending that the trial be terminated due to slow enrollment) Less << - United States, California ... More >> Stanford, California, United States United States, Florida Tampa, Florida, United States United States, Illinois Chicago, Illinois, United States Maywood, Illinois, United States United States, Maryland Baltimore, Maryland, United States United States, Massachusetts Boston, Massachusetts, United States United States, Missouri Saint Louis, Missouri, United States United States, New York New York, New York, United States United States, Ohio Cleveland, Ohio, United States Columbus, Ohio, United States United States, Pennsylvania Philadelphia, Pennsylvania, United States United States, South Carolina Charleston, South Carolina, United States United States, Texas Houston, Texas, United States United States, Washington Seattle, Washington, United States Less <<
NCT00446017 Cardiac Output, Low Phase 3 Completed - -
NCT02549066 Complication of Extracorporeal... More >> Circulation Kidney Circulation Disorder Renal Function Disorder Less << Not Applicable Completed - Sweden ... More >> Department of thoracic anesthesia, Sahlgrenska University Hospital Gothenburg, Sweden, 41345 Less <<
NCT01576094 Low Cardiac Output Syndrome Phase 1 Phase 2 Completed - Spain ... More >> Hospital Universitario La Paz Madrid, Spain, 28046 Less <<
NCT02232399 Congenital Heart Defects Phase 2 Completed - Finland ... More >> Children′s Hospital, Helsinki University Central Hospital Helsinki, Finland, FIN-00029 HYKS Sweden Queen Silvia Children′s Hospital G?teborg, V?stra G?taland, Sweden, 416 85 Less <<
NCT02728128 - Active, not recruiting October 31, 2018 United States, Colorado ... More >> Children's Hospital Colorado Aurora, Colorado, United States, 80045 Less <<
NCT00549107 Low Cardiac Output Syndrome Phase 2 Unknown - Austria ... More >> Children′s Heart Center Linz Recruiting Linz, Austria, 4020 Contact: Evelyn Lechner, MD ?? ?? elechner@aon.at ?? Contact: Anna Hofer, MD ?? ?? anna.hofer@akh.linzat ?? Principal Investigator: Evelyn Lechner, MD ?? ?? ?? Principal Investigator: Anna Hofer, MD Less <<
NCT02640846 Septic Shock ... More >>Cardiomyopathy Less << Phase 4 Active, not recruiting January 2019 Sweden ... More >> Central intensivv?rdsavdelning Sahlgrenska University Hospital Gothenburg, V?stra G?taland, Sweden, 41345 Less <<
NCT02644057 Cardiorenal Syndrome Phase 2 Withdrawn(Could not enroll pat... More >>ients) Less << - United States, New York ... More >> Maimonides Medical Center Brooklyn, New York, United States, 11219 Less <<
NCT02408003 Heart Failure, Diastolic ... More >> Aortic Valve Stenosis Monitoring, Physiologic Physiology Less << Not Applicable Completed - Sweden ... More >> Thoraxoperation/TIVA, Sahlgrenska universitetssjukhuset G?teborg, Sweden, 413 45 Less <<
NCT00966745 Hepatectomy Not Applicable Completed - Korea, Republic of ... More >> Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Less <<
NCT01849094 Healthy Heart... More >> Failure Less << Phase 1 Phase 2 Completed - Australia, Victoria ... More >> Alfred Hospital Melbourne, Victoria, Australia, 3004 Nucleus Network Melbourne, Victoria, Australia, 3004 Less <<
NCT00543309 - Terminated(DSMB recommended te... More >>rmination based on interim outcomes analysis) Less << - -
NCT01966237 - Unknown April 2015 United States, Ohio ... More >> Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 Less <<
NCT00543309 Heart Defects, Congenital Phase 2 Terminated(DSMB recommended te... More >>rmination based on interim outcomes analysis) Less << - United States, Massachusetts ... More >> Children's Hospital Boston Boston, Massachusetts, United States, 02115 Less <<
NCT03207165 Low Cardiac Output Syndrome ... More >> Cardiogenic Shock Acute Coronary Syndrome Pulmonary Edema Less << Phase 4 Recruiting December 2020 Canada, Ontario ... More >> University of Ottawa Heart Institute Recruiting Ottawa, Ontario, Canada, K1Y 4W7 Contact: Benjamin M Hibbert, MD, PhD ?? 613-761-5128 ?? bhibbert@ottawaheart.ca ?? Contact: Rebecca T Mathew, MD ?? 613-696-7000 ?? rmathew@ottawaheart.ca Less <<
NCT01956006 Heart Failure PHASE1|PHASE2 COMPLETED 2018-05-10 Alfred Hospital, Melbourne, Vi... More >>ctoria, 3004, Australia Less <<
NCT03517670 - Not yet recruiting May 30, 2021 -
NCT02712788 Cerebral Vasospasm Phase 2 Terminated(Completion not feas... More >>ible due to lack of eligible subjects.) Less << - United States, Indiana ... More >> Indiana University Heath Methodist Hospital Indianapolis, Indiana, United States, 46202 Less <<
NCT01571037 End Stage Heart Disease ... More >> Right Ventricular Dysfunction Less << Phase 1 Completed - United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198-2265 Less <<
NCT02595541 Pulmonary Hypertension Phase 1 Phase 2 Completed - -
NCT02098629 Myocardial Reperfusion Injury Phase 1 Phase 2 Withdrawn(Difficulty in enroll... More >>ment) Less << December 2017 China, Guangdong ... More >> Yuebei People's Hospital Shaoguan, Guangdong, China, 512025 Less <<
NCT01621971 Pulmonary Hypertension ... More >> Mitral Regurgitation Less << Phase 3 Completed - Korea, Republic of ... More >> Konkuk University Medical Center Seoul, Korea, Republic of, 143729 Less <<
NCT01841177 Congenital Heart Disease PHASE2 COMPLETED 2025-08-20 Hospital for Sick Children, To... More >>ronto, Ontario, M5G 1X8, Canada|The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Less <<
NCT00819377 Valvular Stenosis ... More >> Valvular Insufficiency Hypertension, Pulmonary Coronary Artery Disease Less << Phase 2 Completed - Canada, Quebec ... More >> Montreal Heart Institute Montreal, Quebec, Canada, H1T 1C8 Less <<
NCT01088997 Persistent Fetal Circulation S... More >>yndrome Less << Not Applicable Terminated(Inadequate enrollme... More >>nt) Less << - United States, Michigan ... More >> Children's Hospital of Michigan/Hutzel Women's Hospital Detroit, Michigan, United States, 48201-2196 United States, Pennsylvania The Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT01725776 Pulmonary Hypertension Phase 2 Completed - Canada, Quebec ... More >> Montreal Heart Institute Montreal, Quebec, Canada Less <<
NCT02951130 Congenital Diaphragmatic Herni... More >>a Persistent Pulmonary Hypertension of the Newborn Hypoxemic Respiratory Failure Pulmonary Hypoplasia Less << Phase 2 Recruiting February 2021 United States, Alabama ... More >> University of Alabama at Birmingham Recruiting Birmingham, Alabama, United States, 35233 Contact: Waldemar A Carlo, MD ?? ?? ?? United States, California Stanford University Not yet recruiting Palo Alto, California, United States, 94304 Contact: Krisa P Van Meurs, MD ?? ?? ?? United States, Georgia Emory University Recruiting Atlanta, Georgia, United States, 30303 Contact: David P Carlton, MD ?? ?? ?? United States, Iowa University of Iowa Recruiting Iowa City, Iowa, United States, 52242 Contact: Edward F Bell, MD ?? ?? ?? United States, New Mexico University of New Mexico Recruiting Albuquerque, New Mexico, United States, 87131 Contact: Kristi L Watterberg, MD ?? ?? ?? United States, New York University of Rochester Recruiting Rochester, New York, United States, 14642 Contact: Carl T D'Angio, MD ?? ?? ?? United States, North Carolina RTI International Not yet recruiting Durham, North Carolina, United States, 27709 Contact: Abhik Das, PhD ?? ?? ?? Duke University Not yet recruiting Durham, North Carolina, United States, 27710 Contact: Michael Cotten, MD ?? ?? ?? United States, Ohio Cincinnati Children's Medical Center Not yet recruiting Cincinnati, Ohio, United States, 45267 Contact: Brenda Poindexter, MD ?? ?? ?? Case Western Reserve University, Rainbow Babies and Children's Hospital Recruiting Cleveland, Ohio, United States, 44106 Contact: Michele C Walsh, MD MS ?? ?? ?? Research Institute at Nationwide Children's Hospital Recruiting Columbus, Ohio, United States, 43205 Contact: Pablo Sanchez ?? ?? ?? United States, Pennsylvania University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Barbara Schmidt, MD ?? ?? ?? United States, Rhode Island Brown University, Women & Infants Hospital of Rhode Island Not yet recruiting Providence, Rhode Island, United States, 02905 Contact: Abbot R Laptook, MD ?? ?? ?? United States, Texas University of Texas Southwestern Medical Center at Dallas Not yet recruiting Dallas, Texas, United States, 75235 Contact: Myra Wyckoff, MD ?? ?? ?? University of Texas Health Science Center at Houston Not yet recruiting Houston, Texas, United States, 77030 Contact: Kathleen A Kennedy, MD MPH ?? ?? ?? United States, Utah University of Utah Recruiting Salt Lake City, Utah, United States, 84108 Contact: Bradley Yoder, MD Less <<
NCT02077010 Heart Failure ... More >> Cardiomyopathy Less << Phase 2 Not yet recruiting August 1, 2019 United States, Tennessee ... More >> Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37204 Contact: Zachary L Cox, PharmD ?? 901-201-1683 ?? zachary.l.cox@vanderbilt.edu ?? Principal Investigator: Nicholas Haglund, MD ?? ?? ?? Principal Investigator: Zachary L Cox, PharmD Less <<
NCT01088997 - Terminated(Inadequate enrollme... More >>nt) Less << - -
NCT06077721 Ischemic Heart Disease|Valvula... More >>r Heart Disease Less << RECRUITING 2025-12-24 Konkuk University Medical Cent... More >>er, Seoul, 143-729, Korea, Republic of Less <<
NCT05122884 Septic Shock|Cardiac Output PHASE2 RECRUITING 2025-06-25 Hat Yai Hospital, Hat Yai, Son... More >>gkhla, 10700, Thailand|Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.73mL

0.95mL

0.47mL

23.67mL

4.73mL

2.37mL

47.34mL

9.47mL

4.73mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Cone J, Wang S, et al. Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells. J Cardiovasc Pharmacol. 1999 Oct;34(4):497-504.

[2]Shipley JB, Tolman D, et al. Milrinone: basic and clinical pharmacology and acute and chronic management. Am J Med Sci. 1996 Jun;311(6):286-91.

[3]Ito M, Tanaka T, Saitoh M, Masuoka H, Nakano T, Hidaka H. Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine. Biochem Pharmacol. 1988 May 15;37(10):2041-4. doi: 10.1016/0006-2952(88)90554-0. PMID: 2837222.

[4]Rossing TH, Drazen JM. Effects of milrinone on contractile responses of guinea pig trachea, lung parenchyma and pulmonary artery. J Pharmacol Exp Ther. 1986 Sep;238(3):874-9. PMID: 3746666.

[5]Cone J, Wang S, Tandon N, Fong M, Sun B, Sakurai K, Yoshitake M, Kambayashi J, Liu Y. Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells. J Cardiovasc Pharmacol. 1999 Oct;34(4):497-504. doi: 10.1097/00005344-199910000-00004. PMID: 10511123.

[6]Shakur Y, Fong M, Hensley J, Cone J, Movsesian MA, Kambayashi J, Yoshitake M, Liu Y. Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. Cardiovasc Drugs Ther. 2002 Sep;16(5):417-27. doi: 10.1023/a:1022186402442. PMID: 12652111.

[7]Chen EP, Bittner HB, Davis RD Jr, Van Trigt P 3rd. Milrinone improves pulmonary hemodynamics and right ventricular function in chronic pulmonary hypertension. Ann Thorac Surg. 1997 Mar;63(3):814-21. doi: 10.1016/s0003-4975(97)00011-8. PMID: 9066407.

 

Historical Records

Categories