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[ CAS No. 76903-88-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 76903-88-3
Chemical Structure| 76903-88-3
Structure of 76903-88-3 * Storage: {[proInfo.prStorage]}

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Product Citations

Product Citations

Faisal Aziz ; Kanamata Reddy ; Virneliz Fernandez Vega , et al. DOI:

Abstract: The suppressor of T cell receptor signaling (Sts) proteins are negative regulators of immune signaling. Genetic inactivation of these proteins leads to significant resistance to infection. From a 590,000 compound high-throughput screen, we identified the 2-(1H)-quinolinone derivative, , as a putative inhibitor of Sts activity. , and a small library of derivatives, are competitive, selective inhibitors of Sts-1 with IC50 values from low to submicromolar. SAR analysis indicates that the , the acid, and the moieties are all essential for activity. A crystal structure confirmed the SAR and reveals key interactions between this class of compound and the . Although has poor cell permeability, we demonstrated that a liposomal preparation can inactivate the activity of Sts-1 in cells. These studies demonstrate that Sts-1 enzyme activity can be pharmacologically inactivated and provide foundational tools and insights for the development of immune-enhancing therapies that target the Sts proteins.

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Product Details of [ 76903-88-3 ]

CAS No. :76903-88-3 MDL No. :MFCD00009930
Formula : C7H3ClF2O Boiling Point : No data available
Linear Structure Formula :- InChI Key :RPQWXGVZELKOEU-UHFFFAOYSA-N
M.W : 176.55 Pubchem ID :2724519
Synonyms :

Safety of [ 76903-88-3 ]

Signal Word:Danger Class:8
Precautionary Statements:P280-P305+P351+P338-P310 UN#:3265
Hazard Statements:H314 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 76903-88-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76903-88-3 ]

[ 76903-88-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 718632-46-3 ]
  • [ 76903-88-3 ]
  • C22H26F2N4O5 [ No CAS ]
  • 2
  • [ 52023-68-4 ]
  • [ 76903-88-3 ]
  • [ 931611-21-1 ]
  • 3
  • [ 76903-88-3 ]
  • [ 75-05-8 ]
  • [ 71682-97-8 ]
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