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Chemical Structure| 766-80-3 Chemical Structure| 766-80-3

Structure of 766-80-3

Chemical Structure| 766-80-3

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CAS No.: 766-80-3

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Product Citations

Product Citations

Dube, Phelelisiwe S. ; Angula, Klaudia T. ; Legoabe, Lesetja J. ; Jordaan, Audrey ; Boitz Zarella, Jan M. ; Warner, Digby F. , et al.

Abstract: Herein, we describe 39 novel quinolone compounds bearing a hydrophilic amine chain and varied substituted benzyloxy units. These compounds demonstrate broad-spectrum activities against acid-fast bacterium, Gram-pos. and -neg. bacteria, fungi, and leishmania parasite. Compound 30 maintained antitubercular activity against moxifloxacin-, isoniazid-, and rifampicin-resistant Mycobacterium tuberculosis, while 37 exhibited low micromolar activities (<1 μg/mL) against World Health Organization (WHO) critical pathogens: Cryptococcus neoformans, Acinetobacter baumannii, and Pseudomonas aeruginosa. Compounds in this study are metabolically robust, demonstrating % remnant of >98% after 30 min in the presence of human, rat, and mouse liver microsomes. Several compounds thus reported here are promising leads for the treatment of diseases caused by infectious agents.

Alternative Products

Product Details of [ 766-80-3 ]

CAS No. :766-80-3
Formula : C7H6BrCl
M.W : 205.47
SMILES Code : ClC1=CC(CBr)=CC=C1
MDL No. :MFCD00000597
InChI Key :LZIYAIRGDHSVED-UHFFFAOYSA-N
Pubchem ID :69838

Safety of [ 766-80-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 766-80-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 766-80-3 ]
  • Downstream synthetic route of [ 766-80-3 ]

[ 766-80-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 766-80-3 ]
  • [ 80126-51-8 ]
References: [1] Liebigs Annalen der Chemie, 1989, p. 1215 - 1232.
 

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