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Chemical Structure| 76584-70-8 Chemical Structure| 76584-70-8

Structure of Valproic acid (sodium)(2:1)
CAS No.: 76584-70-8

Chemical Structure| 76584-70-8

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CAS No.: 76584-70-8

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Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor with an IC50 range of 0.5 to 2 mM, and it also inhibits HDAC1 (IC50 of 400 μM) while inducing proteasomal degradation of HDAC2. It activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used to treat epilepsy, bipolar disorder, metabolic disease, HIV infection, and to prevent migraine headaches.

Synonyms: VPA (sodium)(2:1); 2-Propylpentanoic Acid (sodium)(2:1); Divalproex (sodium salt)

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Product Details of Valproic acid (sodium)(2:1)

CAS No. :76584-70-8
Formula : C16H31NaO4
M.W : 310.40
SMILES Code : CCCC(CCC)C([O-])=O.CCCC(CCC)C(O)=O.[Na+]
Synonyms :
VPA (sodium)(2:1); 2-Propylpentanoic Acid (sodium)(2:1); Divalproex (sodium salt)
MDL No. :MFCD00879852
InChI Key :MSRILKIQRXUYCT-UHFFFAOYSA-M
Pubchem ID :23663956

Safety of Valproic acid (sodium)(2:1)

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Related Pathways of Valproic acid (sodium)(2:1)

epigenetics

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01056627 Healthy PHASE1 COMPLETED 2025-03-07 Bioserve Clinical Research Pvt... More >>. Ltd., Hyd, Andhra Pradesh, 500 037, India Less <<
NCT01581788 Healthy PHASE1 COMPLETED 2025-03-11 Veeda Clinical Research, India... More >>, Ahmedabad, Gujrat, 380 015, India Less <<
NCT01132196 Healthy PHASE1 COMPLETED 2025-11-06 Bioserve Clinical Research Pvt... More >>. Ltd.,, Hyderabad, Andhra Pradesh, 500 037, India Less <<
NCT01132183 Healthy PHASE1 COMPLETED 2025-03-07 Bioserve Clinical Research Pvt... More >>. Ltd., Hyd, Andhra Pradesh, 500 037, India Less <<
NCT01581775 Healthy PHASE1 COMPLETED 2025-03-11 Veeda Clinical Research, India... More >>, Ahmedabad, Gujrat, 380 015, India Less <<
NCT01132170 Healthy PHASE1 COMPLETED 2025-11-06 Bioserve Clinical Research Pvt... More >>. Ltd.,, Hyderabad, Andhra Pradesh, 500 037, India Less <<
NCT01055938 Healthy PHASE1 COMPLETED 2025-03-07 Bioserve Clinical Research Pvt... More >>. Ltd., Hyd, Andhra Pradesh, 500 037, India Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL

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