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Chemical Structure| 7497-07-6 Chemical Structure| 7497-07-6
Chemical Structure| 7497-07-6

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CAS No.: 7497-07-6

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NSC 405020 is a non-catalytic Membrane type-1 MMP inhibitor with IC50 > 100 μM.

Synonyms: NSC 405020

4.5 *For Research Use Only !

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D. Vieira ; J. Barralet ; E. J. Harvey ; G. Merle ;

Abstract: Matrix metalloproteinases (MMPs) are essential proteins acting directly in the breakdown of the extra cellular matrix and so in cancer invasion and metastasis. Given its impact on tumor angiogenesis, monitoring MMP-14 provides strategic insights on cancer severity and treatment. In this work, we report a new approach to improve the electrochemical interaction of the MMP-14 with the electrode surface while preserving high specificity. This is based on the detection of the hemopexin (PEX) domain of MMP-14, which has a greater availability with a stable and low-cost commercial molecule, as a recognition element. This molecule, called NSC-405020, is specific of the PEX domain of MMP-14 within the binding pocket. Through the covalent grafting of the NSC-405020 molecule on carbon nanotubes (CNTs), we were able to detect and quantify MMP-14 using electrochemical impedance spectroscopy with a linear range of detection of 10 ng?mL?1 to 100 ng?mL?1, and LOD of 7.5 ng?mL?1. The specificity of the inhibitory small molecule was validated against the PEX domain of MMP-1. The inhibitor loaded CNTs system showed as a desirable candidate to become an alternative to the conventional recognition bioelements for the detection of MMP-14.

Keywords: MMP-14 ; electrochemical detection ; PEX domain ; CNT ; surface modification ; cancer

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Product Details of NSC 405020

CAS No. :7497-07-6
Formula : C12H15Cl2NO
M.W : 260.16
SMILES Code : O=C(NC(CCC)C)C1=CC=C(Cl)C(Cl)=C1
Synonyms :
NSC 405020
MDL No. :MFCD02006898
InChI Key :ARDYECYBETXQFD-UHFFFAOYSA-N
Pubchem ID :346721

Safety of NSC 405020

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • MMP

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.22mL

3.84mL

1.92mL

38.44mL

7.69mL

3.84mL

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