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Chemical Structure| 74654-07-2 Chemical Structure| 74654-07-2
Chemical Structure| 74654-07-2

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CAS No.: 74654-07-2

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m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Product Details of m-PEG3-Amine

CAS No. :74654-07-2
Formula : C7H17NO3
M.W : 163.21
SMILES Code : COCCOCCOCCN
MDL No. :MFCD17215909
InChI Key :OKUWOEKJQRUMBW-UHFFFAOYSA-N
Pubchem ID :3018531

Safety of m-PEG3-Amine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of m-PEG3-Amine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74654-07-2 ]

[ 74654-07-2 ] Synthesis Path-Downstream   1~3

  • 1
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  • 2
  • [ 207399-07-3 ]
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  • C43H60N3O3(1+)*I(1-) [ No CAS ]
  • 3
  • [ 74654-07-2 ]
  • [ 404844-11-7 ]
  • C31H36N6O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
at 120℃; for 1h;Microwave irradiation; General procedure: 4-(Chloromethyl)-N-(4-(methyl-3-(4-(pyridin-3-yl)pyrimidine-2-ylamino)phenyl)benzamide (129 mg, 0.3 mmol) and mPEGn-NH2 (1.50 mmol, n=3, 5, 7, 9) was reacted under microwave conditions at 120C for one hour. After cooling to room temperature, DCM (100 mL) was added to the reaction mixture. The resulting solution was extracted with 1M HCl (50 mL). The acidic aqueous phase was neutralized with sodium carbonate, and then extracted with DCM (100 mL×2). The organic phase was dried over Na2SO4 and the solvent removed under reduced pressure. The resulting residue was purified by column chromatography (biotage: DCM/CH3OH, CH3OH, 5-10%, 25 CV). The desired products were obtained in yields: 65-85%. mPEG3-N-Imatinib (compound la) NMR (500 MHz, CDCl3) delta 2.27 (s, 3H), 2.62 (br., 1H), 2.76 (t, 2H), 3.31 (s, 3H), 3.49 (m, 2H), 3.59 (m, 8H), 3.80 (s, 2H), 7.08 (s, 1H), 7.12 (m, 1H), 7.28 (m, IH), 7.30 (m, 3H), 7.79 (d, 2H), 8.42 (m, 2H), 8.51(d, 2H), 8.62 (d, 1H), 9.17 (s, 1H); LC-MS (m/z) calculated, 556.3, found, 557.3 [M+H]+.
 

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