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Chemical Structure| 74115-12-1 Chemical Structure| 74115-12-1

Structure of 74115-12-1

Chemical Structure| 74115-12-1

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CAS No.: 74115-12-1

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Product Citations

Ouellette, Vincent ; Bouzriba, Chahrazed ; Alvarez, Atziri Corin Chavez ; Bruxelles, Quentin ; Hamel-C?té, Geneviève ; Fortin, Sébastien

Abstract: We developed first-in-class antimitotic prodrugs phenyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) bioactivated by cytochrome (CYP) 1A1 that are highly selective toward several breast cancer cells. However, they show sparingly water solubility. Therefore, we replaced their phenyl ring B with a substituted pyridinyl group preparing novel pyridinyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PYRAIB-SOs) and their hydrochloride salts. Our results evidence that PYRAIB-SO hydrochloride salts show higher water solubility compared to their neutral and PAIB-SO counterparts by up to 625-fold. PYRAIB-SOs with a nitrogen atom at position 3 of the pyridinyl ring exhibited strong antiproliferative activity (IC50: 0.03-3.3 μM) and high selectivity (8-> 1250) toward sensitive CYP1A1-positive breast cancer cells and cells stably transfected with CYP1A1. They induce cell cycle arrest in the G2/M phase and disrupt microtubule dynamic assembly. Enzymatic assays confirmed that CYP1A1 metabolizes PYRAIB-SOs into their active form with in vitro hepatic half-lives (55-120 min) in rodent and human liver microsomes. Overall, this will allow to increase drug concentration for in vivo studies.

Keywords: Anticancer agents ; Antimitotics ; Antimicrotubule agents ; CYP1A1-activated prodrugs ; Pyridinyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates ; PYRAIB-SOs ; Pyridinyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates ; PYRIB-SOs ; Phenyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates ; PAIB-SOs

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Product Details of [ 74115-12-1 ]

CAS No. :74115-12-1
Formula : C5H4ClNO
M.W : 129.54
SMILES Code : C1=C(C=NC=C1Cl)O
MDL No. :MFCD00006379
InChI Key :TUIDQYRZDZRHPQ-UHFFFAOYSA-N
Pubchem ID :582305

Safety of [ 74115-12-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Computational Chemistry of [ 74115-12-1 ] Show Less

Physicochemical Properties

Num. heavy atoms 8
Num. arom. heavy atoms 6
Fraction Csp3 0.0
Num. rotatable bonds 0
Num. H-bond acceptors 2.0
Num. H-bond donors 1.0
Molar Refractivity 31.27
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

33.12 ?2

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

1.11
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

1.58
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

1.44
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

0.4
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

1.61
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

1.23

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-2.19
Solubility 0.83 mg/ml ; 0.0064 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-1.89
Solubility 1.68 mg/ml ; 0.013 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-2.03
Solubility 1.21 mg/ml ; 0.00938 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

 High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

 Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

 No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

 No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

 No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

 No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

 No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

 No
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-5.97 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

 0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

 None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

 0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

 0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

 1.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

0.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

0.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

 No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

 1.34

Application In Synthesis of [ 74115-12-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74115-12-1 ]

[ 74115-12-1 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 74115-12-1 ]
  • [ 161511-85-9 ]
  • [ 161417-51-2 ]
YieldReaction ConditionsOperation in experiment
88% 39a. 5-chloro-3-(N-t-butoxycarbonyl-2-(S)-azetidinylmethoxy)pyridine An ice-cooled solution of the compound from Example 7b (0.242 g, 1.20 mmol) was allowed to react with 3-chloro-5-hydroxypyridine (0.187 g, 1.40 mmol) under the conditions of Example 2a, except that DEAD was replaced with di-t-butylazodicarbonate, to yield the title compound (0.137 g, 88%) after purification on silica gel (ethyl acetate/hexane 2:1). MS (DCI/NH3) m/e: 299 (M+H)+. 1 H NMR (CDCl3, 300 MHz) δ: 8.25 (d, J=1.38 Hz, 1H), 8.21 (br. s, 1H), 7.29 (t, J=2.2 Hz, 1H), 4.53-4.51 (m, 1H), 4.34-4.33 (m, 1H), 4.13 (dd, J=10.3, 2.9 Hz, 1H), 3.91-3.86 (m, 2H), 2.51 (s, 3H), 2.38-2.29 (m, 2H), 1.43 (s, 9H).
39a. 5-chloro-3-(N-t-butoxycarbonyl-2-(S)-azetidinylmethoxy)pyridine An ice-cooled solution of the compound from Example 7b (0.242 g, 1.20 mmol) was allowed to react with 3-chloro-5-hydroxypyridine (0.187 g, 1.40 mmol) under the conditions of Example 2a, except that DEAD was replaced with di-t-butylazodicarbonate, to yield the title compound (0.137 g, 88%o) after purification on silica gel (ethyl acetate/hexane 2:1). MS (DCI/NH3) m/e: 299 (M+H)+. 1 H NMR (CDCl3,300 MHz) δ: 8.25 (d, J=1.38 Hz, 1H), 8.21 (br. s, 1H), 7.29 (t, J=2.2 Hz, 1H), 4.53-4.51 (m, 1H), 4.34-4.33 (m, 1H), 4.13 (dd, J=10.3, 2.9 Hz, 1H), 3.91-3.86 (m, 2H), 2.51 (s, 3H), 2.38-2.29 (m, 2H), 1.43 (s, 9H).
  • 2
  • [ 37718-11-9 ]
  • [ 74115-12-1 ]
  • [ 1027596-87-7 ]
  • 3
  • [ 74115-12-1 ]
  • [ 1072-84-0 ]
  • [ 1026749-59-6 ]
  • 4
  • [ 74115-12-1 ]
  • [ 936247-35-7 ]
YieldReaction ConditionsOperation in experiment
82% With sulfuric acid; nitric acid; at 20℃; Example 15A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT and stirred overnight. The reaction mixture was stirred into an ice/water mixture and it was stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; Example 12A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0 C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The mixture was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H), 8.10 (d, 1H), 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 00 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 mm. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction.10524] LC-MS (Method 1): R=0.60 mm10525] MS (ESneg): mlz=172.9/174.9 (M-H)10526] ?H-NMR (400 MHz, DMSO-d5): oe=7.71 (d, 1H);8.10 (d, 1H); 12.14 (bt 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 2): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulfuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 Mhz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
82% With sulfuric acid; nitric acid; at 0 - 20℃; With ice cooling, 30 g of 5-chloropyridin-3-ol (232mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 mm. The crystals were filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without thrther purification for the next reaction.10372] LC-MS (Method 2): R=0.60 mm10373] MS (ESneg): mlz=172.9/174.9 (M-H)j0374] ?H-NMR (400 MHz, DMSO-d5): oe=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (bt 1H).
74% With sulfuric acid; nitric acid; In water; at 5 - 20℃; for 3 - 144h;Product distribution / selectivity; 5-Chloro-3-pyridinol (15.3 mmol) is dissolved in concentrated H2SO4 (15 ml). At 5 0C concentrated nitric acid (0.9 ml) is added. The reaction mixture is allowed to warm to room temperature over 6 days. The reaction solution is pored onto ice (50 ml) and diluted with water (200 ml). The precipitate is filtered, washed with water and dried at 40 0C in vacuo. 5-Chloro-2-nitro-pyridine-3-ol is obtained as yellow powder; mp. 97; LC- MS (method B): 1.35 min, 175.1 (M+H+).; 5-Chloro-3-pyridinol (382 mmol) is dissolved in concentrated H2SO4 (375 ml). At 5 0C concentrated nitric acid (25 ml) is added. The reaction is allowed to warm to room temperature over 3 hours. The reaction solution is pored onto ice water (5000 ml). The precipitate is filtered, washed with water and dried over night at 40 0C in vacuo. 5- Chloro-2-nitro-pyridine-3-ol is obtained as yellow powder in a yield of 74 %. Mp.: 97 0C; LC-MS (Method B): 1.35 min, 175.1 (MH+).
67% With sulfuric acid; nitric acid; at 5 - 20℃; for 3h; 5-chloropyridin-3-ol(2.00 g, 15.4 mmol) was dissolved in concentrated H2SO4(15 mL) at 5 C. Concentrated nitric acid (1.0 mL) was then added. The reactionwas allowed to warm to room temperature over 3 hrs. The reaction solution waspoured onto ice water (25 mL). The resultant precipitate was filtered, washedwith water and dried overnight at 40 C in vacuo to afford was obtained as ayellow powder, (1.80g, 67%); H NMR (400 MHz, CDCI3) delta7.68 (d, 1H), 8.15 (d, 1H), 10.29 (s, 1H).
With sulfuric acid; nitric acid; at 0 - 20℃;Cooling with ice; Example 27A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, I equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method D): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
33 g With sulfuric acid; nitric acid; at 0 - 20℃; Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H)- 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).
With nitric acid; Example 7A 5-Chloro-2-nitropyridin-3-ol With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and 24 ml of concentrated nitric acid were added slowly at 0 C. The reaction was warmed to RT, stirred overnight and then stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound which was used without further purification for the next reaction. LC-MS (Method 1): Rt=0.60 min MS (ESneg): m/z=172.9/174.9 (M-H) 1H-NMR (400 MHz, DMSO-d6): delta=7.71 (d, 1H); 8.10 (d, 1H); 12.14 (br. 1H).

  • 5
  • [ 74115-12-1 ]
  • [ 108499-32-7 ]
  • [ 1404456-89-8 ]
YieldReaction ConditionsOperation in experiment
To a solution of 5-chloropyridin-3-ol (3.64g, 28.1 mmol) in ACN (77mL) and DMF (7.73mL)vas added Cs2C03 ( 12.47g, 38.3mmol). The reaction mixture was stirred for l Omin and cooled down in an ice bath. A solution of methyl 5-(bromomethyl)thiophene- 2-carboxylate (6.0g, 25.5mmol) in ACN (20mL) was then added dropwise using an addition funnel. The reaction mixture was stirred for 2h and was then concentrated down, before being taken back in water and EtOAc. The organic phase was washed by water and brine, then dried over Na2S04 and filtered. Crude product was filtrated through a silica gel column with 30% EtOAc in hexanes, to afford the desired product (5.3g) as a light brown solid, LC-MS (ES) m/z = 284.0, 286.0 [M+H]+.
  • 6
  • [ 74115-12-1 ]
  • [ 454-16-0 ]
  • [ 315226-65-4 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 25 - 70℃; General procedure: A 4-halonitrobenzene (1.0?equiv), a hydroxyarene, and Cs2CO3 (1.1?equiv) were combined in DMF and the resulting heterogeneous mixture was stirred vigorously at 25?70?°C until all 4-halonitrobenzene was consumed (2?24?h). The reaction mixture was diluted with H2O and was adjusted to pH 5 with 2?N HCl (aq). The solution was extracted three times with EtOAc, and the organic layers were combined, washed once with brine solution, dried over MgSO4, filtered and concentrated in vacuo to furnish the desired diaryl ether that was used directly without further purification.
  • 7
  • [ 104711-65-1 ]
  • [ 74115-12-1 ]
  • C12H8ClN3O [ No CAS ]
 

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Related Parent Nucleus of
[ 74115-12-1 ]

Pyridines

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