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Chemical Structure| 73568-26-0 Chemical Structure| 73568-26-0
Chemical Structure| 73568-26-0

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CAS No.: 73568-26-0

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Product Details of [ 73568-26-0 ]

CAS No. :73568-26-0
Formula : C11H8ClNO
M.W : 205.64
SMILES Code : O=CC1=CC2=CC=CC(C)=C2N=C1Cl
MDL No. :MFCD02227041
InChI Key :YPBRSXNRWFUUOE-UHFFFAOYSA-N
Pubchem ID :689082

Safety of [ 73568-26-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 73568-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73568-26-0 ]

[ 73568-26-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 73568-26-0 ]
  • [ 145214-05-7 ]
  • [ 1167542-08-6 ]
YieldReaction ConditionsOperation in experiment
34% tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; at 100℃; for 2.75h;microwave irradiation; To a solution of 2-chloro-8-methylquinoline-3-carboxaldehyde (250 mg, 1.21 mmol) in DME (3 mL) was added <strong>[145214-05-7]2-(tributylstannyl)oxazole</strong> (0.31 mL, 1.76 mmol) and Pd(PPh3 )4 (70 mg, 0.06 mmol). The reaction mixture was heated in a microwave at 1000C for 45 minutes. More Pd(PPh3)4 (50 mg, 0.04 mmol) was added to the mixture, which was heated at 1000C for 2 h. Purification by column chromatography (SiO2, 0- 100% EtOAc in heptane) gave the title compound as a cream solid (99 mg, 34%). 8R (DMSO-d6) 10.85 (s, IH), 8.91 (s, IH), 8.52 (d, J0.6 Hz, IH), 8.12 (d, J8.1 Hz, IH), 7.86 (d, J 7.0 Hz, IH), 7.64-7.72 (m, 2H), 2.81 (s, 3H). LCMS (ES+) 239 (M+H)+, RT 3.65 minutes (Method 3).
  • 3
  • [ 784-04-3 ]
  • [ 73568-26-0 ]
  • C27H18ClNO [ No CAS ]
 

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Technical Information

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Related Functional Groups of
[ 73568-26-0 ]

Chlorides

Chemical Structure| 73568-31-7

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Aldehydes

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Related Parent Nucleus of
[ 73568-26-0 ]

Quinolines

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A140278 [73568-31-7]

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