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[ CAS No. 7292-74-2 ] {[proInfo.proName]}

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Chemical Structure| 7292-74-2
Chemical Structure| 7292-74-2
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Product Details of [ 7292-74-2 ]

CAS No. :7292-74-2 MDL No. :MFCD00049325
Formula : C8H8FNO2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :LVYBCZIDQKJNFP-UHFFFAOYSA-N
M.W : 169.15 Pubchem ID :265434
Synonyms :
Chemical Name :2-Amino-2-(3-fluorophenyl)acetic acid

Safety of [ 7292-74-2 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 7292-74-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7292-74-2 ]

[ 7292-74-2 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 24424-99-5 ]
  • [ 7292-74-2 ]
  • [ 142121-94-6 ]
YieldReaction ConditionsOperation in experiment
69% To a suspension of <strong>[7292-74-2]2-amino-2-(3-fluorophenyl)acetic acid</strong> (1.00 g, 5.91 mmol) in THF (30 ml) and water (30 ml), 2N sodium hydroxide (29.6 ml, 59.1 mmol) and di-tert-butyl dicarbonate (2.58 g, 1 1.8 mmol) were added and the reaction was stirred at RT for 15h. THF was evaporated, the aqueous phase was cooled and acidified with 37% HCl until pH 1. The desired compound was extracted with EtOAc and the organic phase was washed with brine, dried over Na2SO4 and evaporated to obtain 2-(tert-butoxycarbonylamino)-2-(3- fluorophenyl)acetic acid (1.10 g; 69% yield).
69% With sodium hydroxide; In tetrahydrofuran; water; at 20℃; for 15h; To a suspension of <strong>[7292-74-2]2-amino-2-(3-fluorophenyl)acetic acid</strong> (1.00 g, 5.91 mmol) in THF (30 ml) and water (30 ml), were added 2N sodium hydroxide (29.6 ml, 59.1 mmol) and di-tert-butyl dicarbonate (2.58 g, 11.8 mmol), and the reaction was stirred at RT for 15 hours. THF was evaporated, and the aqueous phase was cooled and acidified with 37% HCl until pH 1. The desired compound was extracted with EtOAc, and the organic phase was washed with brine, dried over Na2SO4 and evaporated to obtain 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetic acid (1.10 g; 69% yield).
  • 2
  • (3-Fluoro-phenyl)-[(E)-hydroxyimino]-acetic acid [ No CAS ]
  • [ 7292-74-2 ]
  • 3
  • [ 271583-22-3 ]
  • [ 7292-74-2 ]
YieldReaction ConditionsOperation in experiment
Substitution in the procedure of Example 3 for the N-tert.-butoxycarbonyl derivative of D-α-aminophenylacetic acid (also called D-α-tert.-butoxycarboxamidophenylacetic acid) of an equimolar weight of the N-tert.-butoxycarbonyl derivative of ... D-α-amino-m-methylphenylacetic acid, D-α-amino-p-chlorophenylacetic acid, D-α-amino-m-chlorophenylacetic acid, D-α-amino-p-fluorophenylacetic acid, D-α-amino-m-fluorophenylacetic acid, D-α-amino-p-aminophenylacetic acid, D-α-amino-p-dimethylaminophenylacetic acid, D-α-amino-m,p-dimethoxyphenylacetic acid, ...
The hydantoin was hydrolyzed at reflux using 1 N NaOH giving 2-amino-2-(3-fluorophenyl)acetic acid which was esterified via Procedure H in methanol to give the title compound.
  • 5
  • [ 271583-58-5 ]
  • [ 7292-74-2 ]
  • 6
  • [ 271583-37-0 ]
  • [ 7292-74-2 ]
  • 7
  • [ 456-48-4 ]
  • [ 7292-74-2 ]
  • 8
  • [ 501-00-8 ]
  • [ 7292-74-2 ]
  • 9
  • [ 7292-74-2 ]
  • (R)-1-[2-tert-Butoxycarbonylamino-2-(3-fluoro-phenyl)-acetyl]-pyrrolidine-2-carboxylic acid [ No CAS ]
  • 10
  • [ 7292-74-2 ]
  • C20H17Cl3FNO6 [ No CAS ]
  • 11
  • [ 7292-74-2 ]
  • C32H41FN6O7 [ No CAS ]
  • 12
  • [ 7292-74-2 ]
  • [2-{(S)-2-[(S)-1-(Benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-ylcarbamoyl]-pyrrolidin-1-yl}-1-(3-fluoro-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester [ No CAS ]
  • 13
  • [ 7292-74-2 ]
  • Boc-D-Phg(F)-Pro-Arg-H*HOAc [ No CAS ]
  • 14
  • [ 7292-74-2 ]
  • rac-2-amino-2-(3-fluorophenyl)ethanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0℃;Heating; D,L-3-fluorophenylglycine (10 g, 59.2 mmol) was added to a suspension of NaBH4 (5.37 g, 142 mmol) in THF (200 mL). The suspension was cooled to 0 C., and an iodine solution (15 g, 59.2 mmol) in THF was added drop wise. The resulting solution was heated while stirring overnight. This solution was cooled to room temperature, quenched with a 20% KOH solution (150 mL) and extracted with DCM (3×). The organics were combined, dried over MgSO4 and the solvent was removed using a rotary evaporator. The product was purified by flash chromatography (0-10% MeOH/EtOAc) to yield 2-amino-2-(3-fluorophenyl)ethanol (I-8) as a white residue.
With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0℃; for 20h;Reflux; Step 1: Preparation of 2-amino- -(3-fluoro-phenyl)-ethanol Amino-(3-fluoro-phenyl)-acetic acid (1.8 g, 10 mmol), NaBH4 (0.95 g, 2.5 mmol) and THF (30 mL) were added dropwise to a solution of iodine (2.54 g, 10 mmol) in anhydrous THF (7 mL) through a pressure-equalizing addition funnel at 0 C. After the ceasing of the hydrogen gas, the reaction mixture was heated to reflux for 20 hours and then cooled to room temperature. The reaction was quenched with methanol, and then dissolved in 20% aqueous KOH. The reaction mixture was stirred overnight to give 1.4 g of crude 2-amino-2-(3-fluoro-phenyl)- ethanol which was directly used in the next step.
With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0℃;Heating; In step 2-1, D,L-3-fluorophenylglycine (10 g, 59.2 mmol) was added to a suspension Of NaBH4 (5.37 g, 142 mmol) in THF (200 mL). The suspension was cooled to 0 0C, and an iodine (15 g, 59.2 mmol) solution in THF was added drop- wise. The resulting solution was heated while stirring over-night. This solution was cooled to room temperature, quenched with a 20 % KOH solution (150 mL), and extracted with dichloro methane (3x). The organics were combined, dried over MgSO4 and the solvent removed using a rotary evaporator. The product was purified with flash chromatography (0 -10 % methanol/ethyl acetate) to yield 2-amino-2-(3-fluorophenyl)ethanol (2-1) as a white residue.
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