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Chemical Structure| 72882-78-1 Chemical Structure| 72882-78-1

Structure of PF-9366
CAS No.: 72882-78-1

Chemical Structure| 72882-78-1

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CAS No.: 72882-78-1

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PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively.

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Product Details of PF-9366

CAS No. :72882-78-1
Formula : C20H19ClN4
M.W : 350.84
SMILES Code : ClC1=CC2=C(N3C(C=C2C4=CC=CC=C4)=NN=C3CCN(C)C)C=C1
MDL No. :MFCD31630724
InChI Key :LYLASWLQCMKZAT-UHFFFAOYSA-N
Pubchem ID :12612431

Safety of PF-9366

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
SKM-1 cells 12.75 μM (IC50) 6 days Moderate impact on proliferation and viability PMC7281730
THP-1 cells 4.210 μM (IC50) 6 days Reduction of proliferation and viability PMC7281730
SEM cells 3.815 μM (IC50) 6 days Reduction of proliferation and viability PMC7281730
HT22 mouse hippocampal neuronal cell line 25 μM 24 hours Inhibition of MAT2A significantly decreased PRMT7 protein expression and activity, as indicated by reduced mono-methylarginine (MMA) production. PMC10988608
CRISPR/Cas9-MLL-AF9 cells 10 μM 6 days Reduction of proliferation and viability, suppression of histone methylation PMC7281730
CRISPR/Cas9-MLL-AF4 cells 10 μM 6 days Reduction of proliferation and viability, suppression of histone methylation PMC7281730

Protocol

Bio Calculators
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1 mM

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2.85mL

0.57mL

0.29mL

14.25mL

2.85mL

1.43mL

28.50mL

5.70mL

2.85mL

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