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Chemical Structure| 71320-77-9
Chemical Structure| 71320-77-9

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CAS No.: 71320-77-9

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Moclobemide is a reversible MAO-A inhibitor with an IC50 of 6.1 μM for hMAO-A, promoting progenitor cell proliferation in the hippocampus of chronically stressed mice.

Synonyms: Ro111163

4.5 *For research use only!

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Product Details of [ Moclobemide ]

CAS No. :71320-77-9
Formula : C13H17ClN2O2
M.W : 268.74
Synonyms :
Ro111163
MDL No. :MFCD00865388
InChI Key :YHXISWVBGDMDLQ-UHFFFAOYSA-N
Pubchem ID :4235

Safety of [ Moclobemide ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P280-P305+P351+P338
Class:8
UN#:1759
Packing Group:

ALK Isoform Comparison

Name MAO MAO-A MAO-B Purity
Sennoside A ++

MAO, IC50: 17 μM

95%
Isatin ++

MAO, IC50: 15 μM

+

MAO-A, IC50: 58 μM

++

MAO-B, IC50: 14 μM

98%
Rasagiline ++++

MAO-A, IC50: 412 nM

++++

MAO-B, IC50: 4.43 nM

99+%
Paeonol +

MAO-A, IC50: 54.6 μM

+

MAO-B, IC50: 42.5 μM

98%
Tranylcypromine hydrochloride +++

MAO-A, IC50: 11.5 μM

+++

MAO-B, IC50: 7 μM

97%
Moclobemide +++

MAO-A (5-HT), IC50: 6.1 μM

99%
Pargyline HCl ++

MAO-A, Ki: 13 μM

+++

MAO-B, Ki: 0.5 μM

97%
Safinamide ++++

MAO-B, IC50: 98 nM

98%

Biological Activity

Target
  • MAO-A

    MAO-A (5-HT), IC50:6.1 μM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02269540 Major Depressive Disorder Early Phase 1 Recruiting July 2018 Canada, Ontario ... More >> Research Imaging Centre, Centre for Addiction and Mental Health Recruiting Toronto, Ontario, Canada, M5T 1R8 Principal Investigator: Jeffrey H Meyer, MD, PhD Less <<
NCT01544309 Hypercholesterolemia With Conc... More >>omitant Type 2 Diabetes Less << Not Applicable Completed - -
NCT00068224 - Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01544309 - Completed - -
NCT01962753 Elderly Major... More >> Depression Less << Not Applicable Unknown May 2018 France ... More >> University Hospital of Besan?on- Jean Minjoz Recruiting Besan?on, France, 25030 Contact: Pierre VANDEL ?? ?? pierre.vandel@univ-fcomte.fr ?? University Hospital of Caen Recruiting Caen, France, 14000 Contact: Sonia DOLLFUS ?? ?? dollfus-s@chu-caen.fr ?? University Hospital of Lille Recruiting Lille, France, 59000 Contact: Jean ROCHE ?? ?? Jean.ROCHE@CHRU-LILLE.FR ?? University Hospital of Nice Recruiting Nice, France, 06000 Contact: Philippe ROBERT ?? ?? robert.p@chu-nice.fr ?? Sainte-Anne Hospital Recruiting Paris, France, 75014 Contact: Thierry GALLARDA ?? ?? T.GALLARDA@ch-sainte-anne.fr ?? Le Rouvray Hospital Recruiting Sotteville lès Rouen, France, 76300 Contact: Marie DESBORDES ?? ?? marie.desbordes@ch-lerouvray.fr ?? University Hospital of Strasbourg - HUS Recruiting Strasbourg, France, 67098 Contact: Frédéric BLANC ?? ?? frederic.blanc@chru-strasbourg.fr ?? University Hospital of Toulouse - Purpan Recruiting Toulouse, France, 31059 Contact: Christophe ARBUS ?? ?? arbus.c@chu-toulouse.fr ?? University Hospital of Tours Recruiting Tours, France, 37000 Contact: Vincent CAMUS ?? ?? vincent.camus@univ-tours.fr Less <<
NCT00704860 Major Depression Phase 4 Completed - Canada, Ontario ... More >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 Less <<
NCT02222220 Clozapine-induced Hypersalivat... More >>ion Less << Phase 3 Completed - Israel ... More >> Be'er Sheva Mental Health Center, Be'er Sheva, Israel, 8417000 Less <<
NCT03010761 Addiction Phase 2 Terminated(all participants fi... More >>nished the trial) Less << - -
NCT00534573 Clozapine-induced Hypersalivat... More >>ion Less << Phase 3 Completed - Israel ... More >> Be'er Sheva Mental Health Center, Tirat HaKarmel Mental Health Center Be'er Sheva, Haifa, Israel Less <<
NCT01926626 Nicotine Dependence Phase 2 Completed - United States, North Carolina ... More >> Duke Center for Smoking Cessation Charlotte, North Carolina, United States, 28210 Duke Center forSmoking Cessation Durham, North Carolina, United States, 27705 Duke Center for Smoking Cessation Winston-Salem, North Carolina, United States, 27103 Less <<
NCT01926626 - Completed - -
NCT02374567 Dementia Depr... More >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders Less << Phase 3 Terminated - Germany ... More >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigsh?he Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.72mL

0.74mL

0.37mL

18.61mL

3.72mL

1.86mL

37.21mL

7.44mL

3.72mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

Reference

 

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