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Chemical Structure| 707-07-3 Chemical Structure| 707-07-3
Chemical Structure| 707-07-3

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CAS No.: 707-07-3

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Product Details of Trimethyl orthobeznoate

CAS No. :707-07-3
Formula : C10H14O3
M.W : 182.22
SMILES Code : COC(OC)(C1=CC=CC=C1)OC
MDL No. :MFCD00008474
InChI Key :IECKAVQTURBPON-UHFFFAOYSA-N
Pubchem ID :69720

Safety of Trimethyl orthobeznoate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Trimethyl orthobeznoate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 707-07-3 ]
  • Downstream synthetic route of [ 707-07-3 ]

[ 707-07-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 22158-41-4 ]
  • [ 707-07-3 ]
  • [ 63388-44-3 ]
YieldReaction ConditionsOperation in experiment
65% at 90℃; for 2 h; 2-phenylnaphtho[2,3-d]oxazole-4,9-dione (A)
Intermediate 3 (500 mg, 1.0 eq), trimethylorthobenzoate (3.6 mL, 8.0 eq) and PPTS (66 mg, 0.1 eq) were combined and heated at 90° C. (oil bath) for 2 hours at which point LC-MS analysis indicated complete consumption of starting material.
The reaction mixture was diluted with Et2O and the resulting yellow ppt collected and washed with Et2O and EtOAc and dried to yield desired product (472 mg, 65percent) as a bright yellow fluffy solid. 1H NMR (400 MHz, CDCl3): δ 7.53-7.62 (3H, M), 7.81 (2H, dd, J=3.5, 5.9), 8.25 (1H, dd, J=3.3, 5.7), 8.29 (1H, dd, J=3.1, 5.9), 8.31-8.34 (2H, M). LRMS (M+H)+: 276.19.
References: [1] Heterocyclic Communications, 2002, vol. 8, # 2, p. 199 - 204.
[2] Patent: US9725425, 2017, B1, . Location in patent: Page/Page column 104; 105.
 

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