Structure of Norfloxacin
CAS No.: 70458-96-7
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Norfloxacin inhibits DNA gyrase and is used as a broad-spectrum antibiotic against both Gram-positive and Gram-negative bacteria.
Synonyms: MK-0366
4.5
*For Research Use Only !
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Shabbir, Sanya ; Hadi, Abdullah ; Jabeen, Nusrat ; Hussain, Mushtaq ;
Abstract: Antibiotics are the major therapeutic arsenal against bacterial infections. Yet, beneath this medical triumph lies an under investigated challenge of the potential teratological and toxicological impacts associated with the use of antibiotics. In the present study, we have explored the teratogenic potential of five commonly used antibiotics (streptomycin, metronidazole, tigecycline, doxycycline and norfloxacin) on Drosophila melanogaster Oregon-R strain. Except norfloxacin, all other tested antibiotics significantly delayed the onset of pupariation. Consistently, metronidazole, doxycycline and tigecycline resulted in statistically significant drops in egg-toadult viability and adversely affected egg-to-pupa transition. In comparison, embryonic exposure of streptomycin impeded pupa-to-fly transition. All tested antibiotics induced morphological defects in antenna, wings, proboscis, eye, head, thorax, haltere and abdomen. Interestingly, developmental exposure of antibiotics resulted in statistically significant decrease in the lifespan of both male and female flies. This suggests an increased incidence of teratogenic faults at the systemic level, which are otherwise not manifested morphologically, due to the exposure of tested antibiotics during development. Taken together, our data show that developmental exposure of antibiotics may induce varying degrees of teratogenicity in D. melanogaster. Given the genomic homology and conservation of major molecular pathways that underpin development in humans and D. melanogaster, the findings do hold translational potential.
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Keywords: Antibiotics ; Drosophila melanogaster ; Development ; Teratogenicity ; Lifespan
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CAS No. : | 70458-96-7 |
Formula : | C16H18FN3O3 |
M.W : | 319.33 |
SMILES Code : | O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=C2)C1=O)O |
Synonyms : |
MK-0366
|
MDL No. : | MFCD00079532 |
InChI Key : | OGJPXUAPXNRGGI-UHFFFAOYSA-N |
Pubchem ID : | 4539 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT01508507 | - | Unknown | March 2014 | India ... More >> Regional Medical Research Center Recruiting Chandrashekharpur, Bhubaneswar, Odisha, India, 751016 Contact: Shantanu K Kar, MD ?? 91-674-301322 ?? rmrcdir@sancharnet.in ?? Contact: Anna S Kerketta, MBBS ?? 91-674-2301387 ?? solani_bara@rediffmail.com ?? Sub-Investigator: Hemant K Khuntia, MBBS Less << | |
NCT02099240 | Osteomyelitis | Early Phase 1 | Recruiting | September 2019 | United States, Kentucky ... More >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD ?? 502-852-1148 ?? jarami01@louisville.edu ?? Contact: David Seligson, MD ?? 502-852-0923 ?? d0seli01@louisville.edu ?? Sub-Investigator: Forest Arnold, DO ?? ?? ?? Sub-Investigator: Timothy Wiemkwn, PhD ?? ?? ?? Sub-Investigator: Robert Kelley, PhD ?? ?? ?? Sub-Investigator: James Summersgill, PhD ?? ?? ?? Sub-Investigator: Ruth Carrico, PhD ?? ?? ?? Sub-Investigator: Julie Harting, PharmD ?? ?? ?? Sub-Investigator: Paula Peyrani, MD ?? ?? ?? Principal Investigator: David Seligson, MD ?? ?? ?? Sub-Investigator: Craig Roberts, MD ?? ?? ?? Principal Investigator: Julio Ramirez, MD Less << |
NCT00701792 | Cirrhosis | Not Applicable | Completed | - | France ... More >> service d'hépatologie CHU jean Minjoz Besancon, France, 25000 CHRU CAEN - Service d'hépato-gastroentérologie Caen, France, 14033 H?pital Beaujon - Hépato-gastroentérologie Clichy, France, 92110 CHU Henri Mondor - Hépato-gastroentérologie Creteil, France, 94010 Hépato-gastroenterologie CHU Bocage Dijon, France, 21034 Centre d'épidémiologie de population EPI 106 Dijon, France, 21079 H?pital Bon secours - Hépato-gastroentérologie Metz, France, 57000 H?pital Saint-Eloi - Hépato-gastroentérologie Montpellier, France, 34295 H?pital Pitié-Salpétrière - Hépato-gastroentérologie Paris, France, 75013 Hepato-gastroenterologie Poitiers, France, 86021 CHU Reims - hépato-gestroentérologie Reims, France, 51092 Clinique des maladies du foie H?pital Pontchailloux Rennes, France, 35000 H?pital Purpan - Hépato-gastroentérologie Toulouse, France, 31059 Less << |
NCT00826670 | Enterobacteriaceae Infections | Phase 4 | Completed | - | Switzerland ... More >> Geneva Universits Hospitals Geneva, Switzerland, 1211 Less << |
NCT03627338 | - | Not yet recruiting | May 31, 2021 | - | |
NCT02463721 | Primary Bacterial Peritonitis | Not Applicable | Recruiting | December 2019 | Egypt ... More >> Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam ?? 00201000040794 ?? Sherif_tropical@yahoo.com Less << |
NCT01881438 | - | Completed | - | - | |
NCT00678613 | Spontaneous Bacterial Peritoni... More >>tis Liver Cirrhosis Less << | Phase 2 Phase 3 | Unknown | - | India ... More >> All India Institute of Medical Sciences Recruiting New Delhi, Delhi, India, 110029 Contact: Subrat K Acharya, DM ?? 91-11-2658-8500 ext 4934 ?? subratacharya2004@yahoo.com ?? Contact: Ramesh Kumar, MD ?? 99-6840-7350 ?? drramesh1977@yahoo.com ?? Sub-Investigator: Ramesh Kumar, MD ?? ?? ?? Sub-Investigator: Geeta Satapathy, MD Less << |
NCT00163982 | Portal Hypertension | UNKNOWN | - | Alfred Hospital, Melbourne, Vi... More >>ctoria, 3181, Australia Less << | |
NCT01134692 | Cirrhosis Var... More >>ices, Esophageal Less << | Phase 3 | Unknown | - | India ... More >> GB Pant hospital Recruiting Delhi, India, 110002 Contact: Nitin Gupta, MD ?? +919718599209 ?? drnitingupta_id@rediffmail.com Less << |
NCT03479736 | - | Completed | - | United States, New Jersey ... More >> Janssen Investigative Site Titusville, New Jersey, United States, 08560 Less << | |
NCT00947336 | Cirrhosis With Ascites | Phase 3 | Completed | - | India ... More >> Department of Gastroenterology, G B Pant Hospital New Delhi, Delhi, India, 110002 Less << |
NCT01527019 | Cystitis | Phase 3 | Withdrawn(the company suspende... More >>d the persecution of this combination) Less << | - | - |
NCT00359853 | Spontaneous Bacterial Peritoni... More >>tis Hepatorenal Syndrome Cirrhosis Less << | Phase 4 | Completed | - | Spain ... More >> Hospital Clinic Barcelona Barcelona, Catalonia, Spain, 08036 Less << |
NCT01039545 | Urinary Tract Infections | Phase 4 | Terminated(New power calculati... More >>on (reduction of necessary patient number)) Less << | - | Switzerland ... More >> Institute for Infectious Diseases, University of Berne Berne, Switzerland, 3010 Less << |
NCT01037959 | Cirrhosis | Phase 3 | Terminated(lack of recruitemen... More >>t) Less << | - | France ... More >> Assisatnce publique Hoptitaux de Paris Clichy, France, 92110 Less << |
NCT00362752 | Hepatopulmonary Syndrome | Phase 2 | Completed | - | Canada, Ontario ... More >> St. Michael's Hospital Toronto, Ontario, Canada, M5B 1W8 Less << |
NCT02120196 | Spontaneous Bacterial Peritoni... More >>tis Ascites Liver Cirrhosis Less << | Phase 3 | Recruiting | December 2023 | Egypt ... More >> Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam ?? 00201000040794 ?? Sherif_tropical@yahoo.com Less << |
NCT01542801 | Adverse Reaction to Other Drug... More >>s and Medicines Less << | Phase 4 | Completed | - | Korea, Republic of ... More >> Korea University Ansan Hospital Ansan, Gyeonggi-do, Korea, Republic of Soonchunhyang University College of Medicine, Bucheon Hospital Bucheon, Korea, Republic of Soonchunhyang University College of Medicine, Cheonan Hospital Cheonan, Korea, Republic of Kyungpuk National University Hospital Daegu, Korea, Republic of Korea University Anam Hospital Seoul, Korea, Republic of Soonchunhyang University College of Medicine, Seoul Hospital Seoul, Korea, Republic of Sungkyunkwan University Gangbuk Samsung Hospital Seoul, Korea, Republic of Less << |
NCT03702426 | Spontaneous Bacterial Peritoni... More >>tis Less << | Not Applicable | Recruiting | September 30, 2019 | India ... More >> Institute of Liver & Biliary Sciences Recruiting New Delhi, Delhi, India, 110070 Contact: Dr Manjul Mishra, MD ?? 01146300000 ?? manjul2883@gmail.com Less << |
NCT03506256 | Urinary Tract Infections | Phase 4 | Not yet recruiting | July 30, 2018 | - |
NCT03695705 | Cirrhosis, Liver | Phase 3 | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.13mL 0.63mL 0.31mL |
15.66mL 3.13mL 1.57mL |
31.32mL 6.26mL 3.13mL |
Tags: Norfloxacin | MK-0366 | Drug Standard | Quinolone | Topoisomerase | Antibacterial | Anti-Infection | DNA Damage | Cell Cycle | Tumor Epigenetics and Gene Regulation | Drug Analysis | Structure | 70458-96-7
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