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Chemical Structure| 698387-09-6 Chemical Structure| 698387-09-6

Structure of Neratinib
CAS No.: 698387-09-6

Chemical Structure| 698387-09-6

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CAS No.: 698387-09-6

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Neratinib (HKI-272) is an orally available, irreversible, and highly selective HER2 and EGFR inhibitor with IC50 values of 59 nM and 92 nM, respectively.

Synonyms: HKI-272

4.5 *For Research Use Only !

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Product Details of Neratinib

CAS No. :698387-09-6
Formula : C30H29ClN6O3
M.W : 557.04
SMILES Code : O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C
Synonyms :
HKI-272
MDL No. :MFCD09752958
InChI Key :JWNPDZNEKVCWMY-VQHVLOKHSA-N
Pubchem ID :9915743

Safety of Neratinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Neratinib

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target

  • EGFR/ErbB1

    EGFR, IC50:92 nM

  • HER2/ErbB2

    HER2, IC50:59 nM

  • HER2

    HER2, IC50:59 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
MDA-MB-453 10 nM 24 h Neratinib monotherapy significantly inhibited cell viability, and its combination with trastuzumab was even more effective. PMC11182766
MDA-MB-361 10 nM 24 h Neratinib monotherapy significantly inhibited cell viability, and its combination with trastuzumab was even more effective. PMC11182766
HCC-1954 1 μM 24 hours To evaluate the synergistic effects of Neratinib with mTOR inhibitors, MEK inhibitors, PI3K α inhibitors, and CDK4/6 inhibitors in HER2+ cells. Results showed that Neratinib exhibited significant synergistic anti-proliferative effects with these inhibitors in HCC-1954 cells. PMC8075007
BT-474 25 nM 24 hours To evaluate the synergistic effects of Neratinib with mTOR inhibitors, MEK inhibitors, PI3K α inhibitors, and CDK4/6 inhibitors in HER2+ cells. Results showed that Neratinib exhibited significant synergistic anti-proliferative effects with these inhibitors in BT-474 cells. PMC8075007
SK-BR-3 10 nM 24 hours To evaluate the synergistic effects of Neratinib with mTOR inhibitors, MEK inhibitors, PI3K α inhibitors, and CDK4/6 inhibitors in HER2+ cells. Results showed that Neratinib exhibited weaker synergistic anti-proliferative effects with these inhibitors in SK-BR-3 cells. PMC8075007
TBCP-1 cells 300 nM 24 hours To investigate the effect of Neratinib on the transcriptome of TBCP-1 cells, it was found that Neratinib induced ferroptosis PMC6693253
SKBR3 cells 5 nM 24 hours To investigate the effect of Neratinib on SKBR3 cells, it was found that Neratinib induced ferroptosis PMC6693253
SKBR-3 cells 45 to 250 ng/mL 48 hours To evaluate the antiproliferative activity of Neratinib and its nanoformulations on SKBR-3 cells. The results showed that Neratinib-loaded dendrimers were more cytotoxic than Neratinib alone, and Trastuzumab-grafted Neratinib dendrimers were more cytotoxic than non-grafted Neratinib dendrimers. PMC7398757
pancreatic cancer cells 50 nM 6 hr Neratinib reduced the phosphorylation of PAK1, Ezrin, and Merlin, and increased the phosphorylation of MAP4K4. PMC10324541
T cell lymphoma cells 50 nM 6 hr Neratinib reduced MST4 expression and Ezrin T567 phosphorylation. PMC10324541
INS-1E cells 5 μM and 10 μM 72 hours Neratinib potently inhibited H2O2- and high glucose/palmitate-induced MST1 activation and apoptosis, and restored PDX1 expression. PMC6825211
Human islet cells 10 μM and 25 μM 72 hours Neratinib significantly inhibited pro-inflammatory cytokine- and high glucose/palmitate-induced MST1 activation and caspase-3 activation. PMC6825211
HCC1954 150 nM twice weekly To evaluate the synergistic anti-proliferative effect of Neratinib and Dasatinib, results showed that the combination was more effective than single agents in inhibiting cell proliferation PMC11396364
HCC1569 150 nM twice weekly To evaluate the synergistic anti-proliferative effect of Neratinib and Dasatinib, results showed that the combination was more effective than single agents in inhibiting cell proliferation PMC11396364
JIMT-1 150 nM twice weekly To evaluate the synergistic anti-proliferative effect of Neratinib and Dasatinib, results showed that the combination was more effective than single agents in inhibiting cell proliferation PMC11396364
HME2-parental cells 1 μM To evaluate the inhibitory effect of neratinib on HER2 phosphorylation PMC9213622

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice CW2 xenograft model Oral 40 mg/kg neratinib, 40 mg/kg alpelisib Once daily for 14 days To test the therapeutic effect of neratinib and alpelisib combination on CW2 xenograft model. PMC8355076
Nude mice Patient-derived xenograft (PDX) models Oral 10 mg/kg Daily for the duration of the experiment To evaluate the antitumor efficacy of Neratinib in combination with CDK4/6 inhibitors, mTOR inhibitors, and MEK inhibitors in HER2+ PDX models. Results showed that the combination of Neratinib with palbociclib significantly enhanced antitumor efficacy in all five PDX models, while combinations with everolimus or trametinib showed varying therapeutic benefits across different models. PMC8075007
Mice Type 1 diabetes (streptozotocin-induced) and type 2 diabetes (obese Leprdb/db) mouse models Intraperitoneal injection 5 mg/kg Once daily for 35 days (type 1 diabetes model) and 31 days (type 2 diabetes model) Neratinib significantly attenuated hyperglycemia and improved β-cell function, survival, and β-cell mass. PMC6825211
Mice HER2-positive breast cancer xenograft models Oral 20 mg/kg 5 days/week, continued treatment To evaluate the efficacy of Neratinib in combination with Trastuzumab, results showed that Neratinib plus Trastuzumab was superior to Pertuzumab plus Trastuzumab in accelerating tumor regression and complete response PMC8159999
Female Albino Wistar rats Neratinib-induced diarrhea model Oral gavage 50 mg/kg Once daily for 28 days To investigate the effect of antibiotics on neratinib-induced diarrhea. Results showed that rats treated with vancomycin or neomycin had significantly lower levels of diarrhea than rats treated with neratinib alone, while the broad-spectrum antibiotic cocktail was less effective. PMC9111977
NSG mice Breast cancer model Oral gavage 27 mg/kg Every other day until tumors reached 1000 mm3 To evaluate the effect of neratinib on tumor growth PMC9213622
BALB/C mice TBCP-1 spontaneous brain metastasis model Oral 60 mg/kg Once daily for 3 weeks To evaluate the efficacy of Neratinib in neoadjuvant therapy, it was found that Neratinib significantly inhibited tumor growth and brain metastasis, and prolonged survival PMC6693253
BALB/c Nude mice HCC1954 xenograft model Oral Neratinib 10 mg/kg, Dasatinib 15 mg/kg 5 days per week for 10 weeks To evaluate the in vivo anti-tumor effect of Neratinib and Dasatinib, results showed that the combination had a prolonged anti-tumor effect compared to single agents PMC11396364

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02396108 Breast Cancer Phase 1 Phase 2 Recruiting March 2019 Singapore ... More >> National University Hospital Recruiting Singapore, Singapore, 119228 Contact: Soo Chin Lee ?? (65) 6779 5555 Less <<
NCT03182634 Advanced Breast Cancer Phase 2 Recruiting November 2023 United Kingdom ... More >> Royal Marsden Hosital, Sutton Recruiting Surrey, England, United Kingdom, SM2 5PT Royal Bournemouth Hospital Recruiting Bournemouth, United Kingdom Addenbrooke's Hospital Recruiting Cambridge, United Kingdom Royal Devon and Exeter Hospital Recruiting Exeter, United Kingdom Beatson West of Scotland Cancer Centre Recruiting Glasgow, United Kingdom Royal Marsden Hospital Recruiting London, United Kingdom University College Hospital London Recruiting London, United Kingdom Christie Hospital Recruiting Manchester, United Kingdom Less <<
NCT00366600 Healthy Phase 1 Completed - United States, Washington ... More >> Northwest Kinetics Tacoma, Washington, United States, 98418 Less <<
NCT00380328 Healthy Phase 1 Completed - -
NCT00708903 Breast Cancer Phase 1 Completed - United States, Washington ... More >> Tacoma, Washington, United States, 98418 Less <<
NCT00550212 Healthy Phase 1 Completed - -
NCT01042379 Breast Neoplasms ... More >> Breast Cancer Breast Tumors Less << Phase 2 Recruiting - -
NCT02977780 Glioblastoma Phase 2 Recruiting May 2021 United States, Alabama ... More >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35294 Contact: L. Burt Nabors, MD ?? 205-934-1432 ?? bnabors@uab.edu ?? United States, Massachusetts Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Isabel Arrillaga-Romany, MD PhD ?? 617-724-8770 ?? iarrillaga@mgh.harvard.edu ?? Principal Investigator: Isabel Arrillaga-Romany, MD PhD ?? ?? ?? Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Brian Alexander, MD MPH ?? 617-732-7560 ?? Brian_Alexander@dfci.harvard.edu ?? Contact: Lisa Doherty, NP ?? 617-632-2166 ?? lisa_doherty@dfci.harvard.edu ?? Principal Investigator: Brian Alexander, MD MPH ?? ?? ?? United States, Minnesota Mayo Clinic Not yet recruiting Rochester, Minnesota, United States, 55905 Contact: Eva Galanis, MD ?? 507-284-2511 ?? galanis.evanthia@mayo.edu ?? United States, New York Columbia University Medical Center Recruiting New York, New York, United States, 10032 Contact: Mary Welch, MD ?? 212-342-0571 ?? mw2517@cumc.columbia.edu ?? United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Manmeet Ahluwalia,, MD ?? 216-444-6145 ?? ahluwam@ccf.org ?? United States, Pennsylvania University of Pittsburgh Medical Center Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Jan Drappatz, MD ?? 412-864-7791 ?? drappatzj@upmc.edu ?? United States, Texas UT MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Contact: John DeGroot, MD ?? 713-745-3072 ?? jdegroot@mdanderson.org ?? United States, Utah Huntsman Cancer Institute Recruiting Salt Lake City, Utah, United States, 84112 Contact: Howard Colman, MD ?? 801-587-4042 ?? Howard.colman@hci.utah.edu ?? United States, Virginia University of Virginia Health System Recruiting Charlottesville, Virginia, United States, 22908 Contact: David Schiff, MD ?? 434-924-5610 ?? Ds4jd@virginia.edu Less <<
NCT00757809 Healthy Subjects Phase 1 Completed - United States, Texas ... More >> Austin, Texas, United States, 78752 United States, Washington Tacoma, Washington, United States, 98418 Less <<
NCT00498745 Healthy Phase 1 Completed - United States, Texas ... More >> San Antonio, Texas, United States, 78217 Less <<
NCT00146172 - Completed - -
NCT00768469 Advanced Malignant Solid Tumor... More >>s Less << Phase 1 Completed - Japan ... More >> Investigational Site Shizuoka, Japan Investigational Site Tokyo, Japan Less <<
NCT00397046 - Completed - -
NCT01494662 Breast Cancer Phase 2 Recruiting December 2023 United States, California ... More >> University of California, San Francisco Medical Center Active, not recruiting San Francisco, California, United States, 94115 United States, District of Columbia MedStar Georgetown Univeristy Hospital Active, not recruiting Washington, District of Columbia, United States, 20007 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Active, not recruiting Baltimore, Maryland, United States, 21231 United States, Massachusetts Beth Israel Deaconess Medical Center Active, not recruiting Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Rachel Freedman, MD ?? ?? ?? Principal Investigator: Rachel Freedman, MD, MPH ?? ?? ?? Massachusetts General Hosptial Recruiting Boston, Massachusetts, United States, 02215 Contact: Beverly Moy, MD ?? ?? ?? Principal Investigator: Beverly Moy, MD ?? ?? ?? United States, Michigan University of Michigan Comprehensive Cancer Center Active, not recruiting Ann Arbor, Michigan, United States, 48109 United States, North Carolina University of North Carolina at Chapel Hill - Lineberger Comprehensive Cancer Center Active, not recruiting Chapel Hill, North Carolina, United States, 27599 Duke University Medical Center Active, not recruiting Durham, North Carolina, United States, 27710 United States, Pennsylvania UPMC Cancer Centers - Magee-Womens Hospital of UPMC Active, not recruiting Pittsburgh, Pennsylvania, United States, 15213 United States, Texas Baylor College of Medicine Lester and Sue Smith Breast Center Active, not recruiting Houston, Texas, United States, 77030 MD Anderson Cancer Center Active, not recruiting Houston, Texas, United States, 77030 Less <<
NCT00398567 Advanced Breast Cancer Phase 1 Phase 2 Completed - United States, California ... More >> City of Hope National Medical Center Duarte, California, United States, 91010-3000 LAC/USC Medical Center, USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 City of Hope National Medical Center Pasadena, California, United States, 91105 United States, Maryland University of Maryland, University of Maryland Medical Center Baltimore, Maryland, United States, 21201 United States, North Carolina Duke University, Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Pennsylvania Fox Chase Cancer Center Philadelphia, Pennsylvania, United States, 19111 China, Jiangsu Chinese Nanjing Bayi Hospital Nanjing, Jiangsu, China, 210002 China, Tianjin Tianjin Union Medicine Center Tianjin, Tianjin, China, 300121 China Cancer Hospital, Academy of Med Science and Peking Union Med Beijing, China, 100021 307 Hospital of Chinese People's Liberation Army Beijing, China, 100071 Chinese PLA General Hospital Beijing, China, 100853 France Institut Curie Paris, France, 75005 Centre Rene Gauducheau Saint-Herblain, France, 44805 Switzerland Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Less <<
NCT00398567 - Completed - -
NCT00768469 - Completed - -
NCT01008150 Breast Cancer Phase 2 Completed - -
NCT00146172 Breast Neoplasms Phase 1 Completed - United States, Florida ... More >> H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida, United States, 33612 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, Ohio The Cleveland Clinic Foundation Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Tennessee The Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 Less <<
NCT02593708 Solid Tumor Phase 1 Terminated(toxicity) - United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 Less <<
NCT01008150 - Completed - -
NCT00777101 Advanced Breast Cancer ... More >> Breast Cancer Less << Phase 2 Completed - -
NCT00397046 Tumors Phase 1 Completed - Japan ... More >> The Cancer Institute Hospital of Japanese Foundation for Cancer Research Koto, Tokyo, Japan, 135-8550 Shizuoka Cancer Center Shizuoka, Japan, 1411-8777 Less <<
NCT00860223 Healthy Phase 1 Completed - United States, Florida ... More >> Miami, Florida, United States, 33126 Less <<
NCT00777101 - Completed - -
NCT00814060 Healthy Subjects Phase 1 Completed - United States, Washington ... More >> Tacoma, Washington, United States, 98418 Less <<
NCT01670877 Breast Neoplasms Phase 2 Recruiting November 30, 2020 United States, Alabama ... More >> University of Alabama Cancer Center Recruiting Birmingham, Alabama, United States, 35294 Contact: Andres Forero-Torres, M.D. ?? 205-975-2837 ?? aforero@uab.edu ?? Principal Investigator: Andres Forero, M.D. ?? ?? ?? United States, California University of Southern California Keck School of Medicine Recruiting Los Angeles, California, United States, 90033 Contact: Janice Lu, M.D., Ph.D. ?? 323-865-3000 ?? janice.lu@med.usc.edu ?? Principal Investigator: Janice Lu, M.D., Ph.D. ?? ?? ?? Stanford Medicine Cancer Institute Recruiting Stanford, California, United States, 94305 Contact: Mark Pegram, M.D. ?? 650-723-5801 ?? mpegram@stanford.edu ?? Principal Investigator: Mark Pegram, M.D. ?? ?? ?? United States, Florida University of Miami Hospital and Clinics Recruiting Miami, Florida, United States, 33136 Contact: Marc E Lippman, M.D. ?? ?? mlippman@med.miami.edu ?? Principal Investigator: Marc E Lippman, M.D. ?? ?? ?? Sub-Investigator: Carmen Calfa, M.D. ?? ?? ?? Sub-Investigator: Mohammad Jahanzeb, M.D. ?? ?? ?? Sub-Investigator: Judith Hurley, M.D. ?? ?? ?? Sub-Investigator: Frances Valdes-Albini, M.D. ?? ?? ?? Sub-Investigator: Lawrence Negret, M.D. ?? ?? ?? Sub-Investigator: Reshma Mahtani, M.D. ?? ?? ?? Sub-Investigator: Catherine Welsh, M.D. ?? ?? ?? Sub-Investigator: Alejandra Perez, M.D. ?? ?? ?? Sub-Investigator: Joyce Slingerland, M.D. ?? ?? ?? Sub-Investigator: Charles Vogel, M.D. ?? ?? ?? United States, Illinois Northwestern University - Feinberg School of Medicine Recruiting Chicago, Illinois, United States, 60611 Contact: Massimo Cristofanilli, M.D. ?? 312-695-6180 ?? massimo.cristofanilli@nm.org ?? Principal Investigator: Massimo Cristofanilli, M.D. ?? ?? ?? Sub-Investigator: William Gradishar, M.D. ?? ?? ?? Sub-Investigator: Lisa Flaum, M.D. ?? ?? ?? Rush University Medical Center Recruiting Chicago, Illinois, United States, 60612 Contact: Melody Cobleigh, M.D. ?? ?? melody_cobleigh@rush.edu ?? Principal Investigator: Melody Cobleigh, M.D. ?? ?? ?? United States, Massachusetts Dana-Farber Cancer Institute, Harvard University Recruiting Boston, Massachusetts, United States, 02215 Contact: Rachel Freedman, M.D. ?? 617-632-6876 ?? rachel_freedman@dfci.harvard.edu ?? Principal Investigator: Rachel Freedman, M.D. ?? ?? ?? United States, Michigan University of Michigan Active, not recruiting Ann Arbor, Michigan, United States, 48109 United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Matthew P. Goetz, M.D. ?? 507-293-1605 ?? Goetz.Matthew@mayo.edu ?? Principal Investigator: Matthew P. Goetz, M.D. ?? ?? ?? United States, Missouri St. Luke's Cancer Institute Recruiting Kansas City, Missouri, United States, 64111 Contact: Timothy J Pluard, M.D. ?? 816-932-6005 ?? tpluard@saint-lukes.org ?? Principal Investigator: Timothy J Pluard, M.D. ?? ?? ?? Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Cynthia Ma, M.D., Ph.D. ?? 314-362-9383 ?? cynthiaxma@wustl.edu ?? Principal Investigator: Cynthia X Ma, M.D., Ph.D. ?? ?? ?? Sub-Investigator: Michael Naughton, M.D. ?? ?? ?? Sub-Investigator: Rama Suresh, M.D. ?? ?? ?? Sub-Investigator: Foluso Ademuyiwa, M.D. ?? ?? ?? Sub-Investigator: Leonel Hernandez-Aya, M.D. ?? ?? ?? Sub-Investigator: Ron Bose, M.D., Ph.D. ?? ?? ?? Sub-Investigator: Katherine Weilbaecher, M.D. ?? ?? ?? Sub-Investigator: Ashley Frith, M.D. ?? ?? ?? Sub-Investigator: Haeseong Park, M.D. ?? ?? ?? Sub-Investigator: Matthew Cherian, M.D. ?? ?? ?? Sub-Investigator: Lindsay Peterson, M.D. ?? ?? ?? United States, North Carolina University of North Carolina at Chapel Hill (Lineberger Comprehensive Cancer Center) Recruiting Chapel Hill, North Carolina, United States, 27514 Contact: Carey Anders, M.D. ?? 919-966-4431 ?? canders@med.unc.edu ?? Principal Investigator: Carey Anders, M.D. ?? ?? ?? Sub-Investigator: E. Claire Dees, M.D. ?? ?? ?? Sub-Investigator: Francis A. Collichio, M.D. ?? ?? ?? Sub-Investigator: Trevor A. Jolly, M.D. ?? ?? ?? Sub-Investigator: Katherine Reeder-Hays, M.D. ?? ?? ?? Duke Cancer Institute at Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Kimberly Blackwell, M.D. ?? 919-681-0874 ?? kimberly.blackwell@duke.edu ?? Principal Investigator: Kimberly Blackwell, M.D. ?? ?? ?? United States, South Dakota Avera Cancer Institute Recruiting Sioux Falls, South Dakota, United States, 57105 Contact: Amy Krie, M.D. ?? 605-322-6900 ?? amy.krie@avera.org ?? Principal Investigator: Amy Krie, M.D. ?? ?? ?? United States, Texas Baylor College of Medicine Recruiting Houston, Texas, United States, 77030 Contact: Julie Nangia, M.D. ?? 713-798-1999 ?? nangia@bcm.edu ?? Principal Investigator: Julie Nangia, M.D. ?? ?? ?? Sub-Investigator: Matthew JC Ellis, MB, Ph.D. ?? ?? ?? Canada, British Columbia BC Cancer Agency Active, not recruiting Vancouver, British Columbia, Canada, V5Z 1L3 Canada, Ontario Princess Margaret Cancer Centre Active, not recruiting Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00266877 Carcinoma, Non-Small-Cell Lung... More >>|Lung Neoplasms Less << PHASE2 COMPLETED 2025-01-09 USC Norris Comprehensive Cance... More >>r Center, Los Angeles, California, 90033, United States|Midwestern Regional Medical Center, Zion, Illinois, 60099, United States|Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston, Massachusetts, 02114, United States|University of Minnesota, Minneapolis, Minnesota, 55455, United States|Memorial Sloan-Kettering, New York, New York, 10021, United States|Carolinas Hematology-Oncology Associates, Charlotte, North Carolina, 28203, United States|Case Western Reserve University, Cleveland, Ohio, 44106, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37232-6868, United States|Swedish Cancer Institute, Seattle, Washington, 98104, United States|Seattle Cancer Care Alliance, Seattle, Washington, 98109, United States|Institut Gustave Roussy, Villejuif, 94805, France|Országos Korányi TBC és Pulmonológiai Intézet, Budapest, H-1529, Hungary|University of Debrecen, Debrecen, H-4012, Hungary|Akademia Medyczna W Gdansku, Gdansk, 80-952, Poland|Mazowieckie Centrum Leczenia Chorób P?uc i Gru?licy, Otwock, 05-400, Poland|Wielkopolskie Centrum Chorób P?uc i Gru?licy, Poznan, 60-569, Poland|Dolno?l?skie Centrum Chorób P?uc we Wroc?awiu, Wroc?aw, 54-439, Poland|Hospital Germans Trias I Puyol, Badalona, Barcelona, 08916, Spain Less <<
NCT00932464 Healthy Phase 1 Withdrawn(Study withdrawn as i... More >>t no longer is deemed necessary per project status.) Less << August 2012 -
NCT00915018 - Completed - -
NCT00915018 Breast Cancer Phase 2 Completed - -
NCT00706030 Breast Cancer ... More >> Advanced Malignant Solid Tumors Less << Phase 1 Phase 2 Completed - -
NCT00706030 - Completed - -
NCT01423123 Breast Cancer Phase 1 Completed - United States, New Jersey ... More >> Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08901 United States, Pennsylvania NSABP Foundation, Inc. Pittsburgh, Pennsylvania, United States, 15212 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232-1305 United States, West Virginia West Virginia University Hospitals Morgantown, West Virginia, United States, 26506-9162 Less <<
NCT00266877 Carcinoma, Non-Small-Cell Lung... More >>|Lung Neoplasms Less << PHASE2 COMPLETED 2025-01-09 USC Norris Comprehensive Cance... More >>r Center, Los Angeles, California, 90033, United States|Midwestern Regional Medical Center, Zion, Illinois, 60099, United States|Massachusetts General Hospital, Yawkey Center for Outpatient Care, Boston, Massachusetts, 02114, United States|University of Minnesota, Minneapolis, Minnesota, 55455, United States|Memorial Sloan-Kettering, New York, New York, 10021, United States|Carolinas Hematology-Oncology Associates, Charlotte, North Carolina, 28203, United States|Case Western Reserve University, Cleveland, Ohio, 44106, United States|Cleveland Clinic, Cleveland, Ohio, 44195, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37232-6868, United States|Swedish Cancer Institute, Seattle, Washington, 98104, United States|Seattle Cancer Care Alliance, Seattle, Washington, 98109, United States|Institut Gustave Roussy, Villejuif, 94805, France|Országos Korányi TBC és Pulmonológiai Intézet, Budapest, H-1529, Hungary|University of Debrecen, Debrecen, H-4012, Hungary|Akademia Medyczna W Gdansku, Gdansk, 80-952, Poland|Mazowieckie Centrum Leczenia Chorób P?uc i Gru?licy, Otwock, 05-400, Poland|Wielkopolskie Centrum Chorób P?uc i Gru?licy, Poznan, 60-569, Poland|Dolno?l?skie Centrum Chorób P?uc we Wroc?awiu, Wroc?aw, 54-439, Poland|Hospital Germans Trias I Puyol, Badalona, Barcelona, 08916, Spain Less <<
NCT00445458 Advanced Breast Cancer ... More >> Advanced Malignant Solid Tumors Breast Neoplasms Less << Phase 1 Phase 2 Completed - -
NCT00445458 - Completed - -
NCT00838539 Neoplasms Mal... More >>ignant Carcinoma Less << Phase 1 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 France Institut Gustave Roussy Villejuif, France, 94805 Less <<
NCT00864487 Healthy Subjects PHASE1 COMPLETED 2025-05-09 Miami, Florida, 33126, United ... More >>States Less <<
NCT01956253 Bladder Cancer NO_LONGER_AVAILABLE 2025-06-14 North Carolina Cancer Hospital... More >> (UNC), Chapel Hill, North Carolina, 27599, United States Less <<
NCT00781430 Hepatic Insufficiency Phase 1 Completed - Russian Federation ... More >> Pfizer Investigational Site Moscow, Russian Federation, 125206 Less <<
NCT03094052 HER2-positive Breast Cancer Phase 2 Recruiting December 2, 2020 United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center Recruiting San Francisco, California, United States, 94115 Contact: Jo Chien ?? 877-827-3222 ?? cancertrials@ucsf.edu ?? Principal Investigator: Jo Chien, MD Less <<
NCT02334501 Healthy Phase 1 Completed - United States, Arizona ... More >> Celerion Tempe, Arizona, United States, 85283 Less <<
NCT00741260 Breast Cancer Phase 1 Phase 2 Completed - -
NCT00838539 - Completed - -
NCT03101748 Malignant Neoplasm of Breast Phase 1 Phase 2 Recruiting January 2026 United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact ?? ?? blim@mdanderson.org Less <<
NCT00741260 - Completed - -
NCT00300781 - Completed - -
NCT02673398 HER2 Positive Breast Carcinoma... More >> Recurrent Breast Carcinoma Stage IV Breast Cancer Less << Phase 2 Recruiting November 2018 United States, California ... More >> City of Hope Corona Recruiting Corona, California, United States, 92879 Contact: Cheryl Corpus ?? 626-256-4673 ext 81529 ?? ?? Sub-Investigator: Misagh Karimi, MD ?? ?? ?? City of Hope Medical Center Recruiting Duarte, California, United States, 91010 Contact: Yuan Yuan, MD, PhD ?? 800-826-4673 ?? ?? Principal Investigator: Yuan Yuan, MD, PhD ?? ?? ?? City of Hope Antelope Valley Recruiting Lancaster, California, United States, 93534 Contact: Regan Johnson ?? 626-256-4673 ext 25648 ?? ?? Sub-Investigator: Mohammad Fekrazad, MD ?? ?? ?? City of Hope Mission Hills Recruiting Mission Hills, California, United States, 91345 Contact: Amy Shousha ?? 626-256-4673 ext 81865 ?? ?? Sub-Investigator: Suzy Melkonian, MD ?? ?? ?? City of Hope Rancho Cucamonga Recruiting Rancho Cucamonga, California, United States, 91730 Contact: Valerie Estala ?? 626-256-4673 ext 81699 ?? ?? Sub-Investigator: Behnam Ebrahimi, MD ?? ?? ?? City of Hope South Pasadena Recruiting South Pasadena, California, United States, 91030 Contact: Odessa Rodriguez ?? 626-256-4673 ext 81409 ?? ?? Sub-Investigator: Christina Yeon, MD ?? ?? ?? City of Hope West Covina Recruiting West Covina, California, United States, 91790 Contact: Mei Zheng ?? 626-256-4673 ext 81336 ?? ?? Sub-Investigator: Gargi Upadhyaya, MD Less <<
NCT01111825 - Completed - -
NCT00300781 Breast Neoplasms ... More >> Neoplasms Less << Phase 2 Completed - -
NCT00878709 Breast Cancer Phase 3 Active, not recruiting November 2020 -
NCT00878709 - Active, not recruiting - -
NCT01111825 Breast Cancer Phase 1 Phase 2 Completed - United States, Arizona ... More >> Western Regional Medical Center, Inc. Goodyear, Arizona, United States, 85338 United States, California USC/Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, New York Memorial Sloan Kettering Cancer Center (MSKCC) New York, New York, United States, 10065 Weill Cornell Medical College - New York - Presbyterian Hospital New York, New York, United States, 10065 Denmark Roskilde Hospital Roskilde, Denmark, 4000 France Institut Gustave Roussy Villejuif, France, 94800 Hong Kong UNIMED Medical Institute Wan Chai, Hong Kong Spain Hospital Universitario Sant Joan de Reus Tarragona, Reus, Spain, 43204 Hospital Universitario Vall d'Hebron Barcelona, Spain, 08035 Hospital Universitari Arnau de Vilanova de Lleida Lleida, Spain, 25006 United Kingdom Edinburgh Cancer Center, Western General Hospital Edinburgh, United Kingdom, EH4 2XU The Royal Marsden NHS Foundation Trust London, United Kingdom, SW3 6JJ Less <<
NCT01142063 - Completed - United States, Connecticut ... More >> Investigational Site New Haven, Connecticut, United States, 06511 Less <<
NCT02236000 Breast Cancer Phase 1 Phase 2 Recruiting July 2019 United States, Florida ... More >> Cleveland Clinic Weston Recruiting Weston, Florida, United States, 33331 United States, Illinois Cancer Care Specialists of Central Illinois Recruiting Decatur, Illinois, United States, 62526 Crossroads Cancer Center Recruiting Effingham, Illinois, United States, 62401 Cancer Care Specialists of Central Illinois-Swansea Recruiting Swansea, Illinois, United States, 62226 United States, Ohio Cleveland Clinic Recruiting Cleveland, Ohio, United States, 44195 Contact: Diana Gosik, RN, BS ?? 800-270-3165 ?? ?? United States, Oklahoma Stephenson Cancer Center at the University of Oklahoma Health Services Center Recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Pennsylvania UPMC- Hillman Cancer Center-Monroeville Recruiting Monroeville, Pennsylvania, United States, 15146 Alleheny General Hospital Recruiting Pittsburgh, Pennsylvania, United States, 15212 Hillman Cancer Center Recruiting Pittsburgh, Pennsylvania, United States, 15213 Magee Womens Hospital of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15213 Contact: Diana Gosik, RN, BS ?? 800-270-3165 ?? ?? University of Pittsburgh Recruiting Pittsburgh, Pennsylvania, United States, 15213 UPMC- St. Margaret Recruiting Pittsburgh, Pennsylvania, United States, 15215 United States, Rhode Island Women & Infants Hospital of Rhode Island Recruiting Providence, Rhode Island, United States, 02905 Contact: Diana Gosik, RN, BS ?? 800-270-3165 ?? ?? United States, West Virginia West Virginia University Recruiting Morgantown, West Virginia, United States, 26501 Contact: Diana Gosik, RN, BS ?? 800-270-3165 Less <<
NCT01953926 Malignant Solid Tumor ... More >> Fibrolamellar Carcinoma Less << Phase 2 Recruiting March 2022 -
NCT02400476 Early Stage HER2+ Breast Cance... More >>r Less << Phase 2 Recruiting March 2020 -
NCT01960023 Colorectal Cancer Phase 1 Phase 2 Unknown December 2016 United States, Florida ... More >> University of Florida Gainesville, Florida, United States, 32610 MD Anderson Cancer Center Orlando Orlando, Florida, United States, 32806 United States, Idaho Saint Luke's Mountain States Tumor Institute Boise, Idaho, United States, 83712 United States, Illinois Decatur Memorial Hospital Decatur, Illinois, United States, 62526 United States, Michigan Saint Joseph Mercy Hospital Ann Arbor, Michigan, United States, 48106 Henry Ford Health System Detroit, Michigan, United States, 48202 United States, North Carolina Levine Cancer Institute Charlotte, North Carolina, United States, 28204 Novant Health Presbyterian Medical Center Charlotte, North Carolina, United States, 28204 United States, Pennsylvania Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107 Allegheny General Hospital Pittsburgh, Pennsylvania, United States, 15215 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 Reading Hospital and Medical Center West Reading, Pennsylvania, United States, 19611 Less <<
NCT01827267 HER2-mutant Non-Small Cell Lun... More >>g Cancer Less << Phase 2 Completed - United States, California ... More >> City of Hope Duarte, California, United States, 91010 University of California Los Angeles Santa Monica, California, United States, 94040 United States, Colorado University of Colorado Aurora, Colorado, United States, 80045 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Maryland Johns Hopkins Baltimore, Maryland, United States, 21231 United States, Massachusetts Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 Massachusettes General Hospital Boston, Massachusetts, United States, 02215 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Ohio State University Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37232 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75390 MD Anderson Cancer Center Houston, Texas, United States, 77030 France CHU de Grenoble Hopital Albert Michallon Grenoble, France, 38043 CHRU de Lille - Hopital Calmette Lille, France, 59037 Hopital Nord Marseille, France, 13915 Hopitaux universitaires de Strasbourg Nouvel Hopital Civil Strasbourg, France, 167091 CHU de Toulous Hopital Larre Toulouse, France, 30030 Institut Gustave Roussy Villejuif, France, 94805 Less <<
NCT00958724 Advanced Malignant Solid Tumor... More >>s Less << Phase 1 Completed - Japan ... More >> Shizuoka Cancer Center Shizuoka, Japan, 411-8777 The Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo, Japan, 135-8550 Less <<
NCT00958724 - Completed - -
NCT01827267 - Completed - -
NCT03377387 Breast Cancer Phase 1 Phase 2 Recruiting December 2019 United States, Connecticut ... More >> Hartford Healthcare Cancer Institute @ Hartford Hospital Recruiting Hartford, Connecticut, United States, 06102 Contact: Rajani Nadkarni, MD ?? 203-238-7747 ?? ?? United States, Florida Baptist Health South Florida Recruiting Miami, Florida, United States, 33143 Contact: Grace Wang, MD ?? 305-595-2141 ?? ?? United States, New Jersey Memorial Sloan Kettering at Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? Memorial Sloan Kettering Bergen Recruiting Montvale, New Jersey, United States, 07645 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? United States, New York Memorial Sloan Kettering Commack Recruiting Commack, New York, United States, 11725 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? Contact: Shanu Modi, MD ?? 646-888-4564 ?? ?? Principal Investigator: Chau Dang, MD ?? ?? ?? Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Chau Dang, MD ?? 914-367-7181 ?? ?? United States, Pennsylvania Lehigh Valley Health Network Recruiting Allentown, Pennsylvania, United States, 18103 Contact: Ranju Gupta, MD ?? 610-402-7880 Less <<
NCT01128842 Advanced Malignant Solid Tumor... More >>s Less << Phase 1 Completed - Japan ... More >> Investigational Site Shizuoka, Japan Investigational Site Tokyo, Japan Less <<
NCT03457896 Metastatic Colorectal Cancer Phase 2 Recruiting January 2021 United States, California ... More >> Kaiser Permanente-Anaheim Recruiting Anaheim, California, United States, 92806 Kaiser Permanente-Baldwin Recruiting Baldwin Park, California, United States, 91706 Kaiser Permanente-Bellflower Recruiting Bellflower, California, United States, 90706 Kaiser Permanente-Fontana Recruiting Fontana, California, United States, 92335 Kaiser Permanente-Harbor City Recruiting Harbor City, California, United States, 90710 Kaiser Permanente-Irvine Recruiting Irvine, California, United States, 92618 Kaiser Permanente-Sunset Recruiting Los Angeles, California, United States, 90027 Kaiser Permanente-West Los Angeles (Cadillac) Recruiting Los Angeles, California, United States, 90034 Kaiser Permanente-Panorama City Recruiting Panorama City, California, United States, 91402 Kaiser Permanente-Riverside Recruiting Riverside, California, United States, 92505 Kaiser Permanente-Medical Group Recruiting San Diego, California, United States, 92108 Kaiser Permanente-Zion Recruiting San Diego, California, United States, 92120 Kaiser Permanente-San Marcos Recruiting San Marcos, California, United States, 92078 Kaiser Permanente-Woodland Hills Recruiting Woodland Hills, California, United States, 91367 United States, Florida UF Health Davis Cancer Pavilion and Shands Medical Plaza Recruiting Gainesville, Florida, United States, 32608 University of Florida Recruiting Gainesville, Florida, United States, 32610 United States, Illinois Cancer Care Specialists of Central IL-Decatur Recruiting Decatur, Illinois, United States, 62526 Decatur Memorial Hospital Recruiting Decatur, Illinois, United States, 62526 Crosslands Cancer Center Recruiting Effingham, Illinois, United States, 62401 Cancer Care Specialists of Central IL-Swansea Recruiting Swansea, Illinois, United States, 62226 United States, Michigan Trinity Health Michigan Recruiting Ann Arbor, Michigan, United States, 48106 Bronson Battle Creek Recruiting Battle Creek, Michigan, United States, 49017 St. Joseph Mercy Brighton Recruiting Brighton, Michigan, United States, 48114 St. Joseph Mercy Canton Recruiting Canton, Michigan, United States, 48188 St. Joseph Mercy Chelsea Recruiting Chelsea, Michigan, United States, 48118 Cancer Research Consortium of West Michigan Recruiting Grand Rapids, Michigan, United States, 49503-2560 Spectrum Health Butterworth Recruiting Grand Rapids, Michigan, United States, 49503 St. Mary Mercy Hospital Recruiting Livonia, Michigan, United States, 48154 Mercy Health Mercy Campus Recruiting Muskegon, Michigan, United States, 49444 St. Mary's of Michigan Recruiting Saginaw, Michigan, United States, 48601 Lakeland Healthcare-Marie Yeager Cancer Center Recruiting Saint Joseph, Michigan, United States, 49085 Metro Health Hospital Recruiting Wyoming, Michigan, United States, 49519 United States, Tennessee Wellmont Cancer Institute Recruiting Johnson City, Tennessee, United States, 37601 Wellmont Cancer Institute Recruiting Kingston, Tennessee, United States, 37660 United States, Virginia Wellmont Medical Associates-Oncology and Hematology Recruiting Bristol, Virginia, United States, 24201 Southwest Virginia Regional Cancer Center Recruiting Norton, Virginia, United States, 24273 Less <<
NCT03065387 Malignant Neoplasm of Breast ... More >> Malignant Neoplasms of Digestive Organs Malignant Neoplasms of Female Genital Organs Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites Malignant Neoplasms of Independent (Primary) Multiple Sites Malignant Neoplasms of Lip Oral Cavity and Pharynx Malignant Neoplasms of Mesothelial and Soft Tissue Malignant Neoplasms of Respiratory and Intrathoracic Organs Malignant Neoplasms of Thyroid and Other Endocrine Glands Malignant Neoplasms of Urinary Tract Neoplasms of Uncertain or Unknown Behavior Less << Phase 1 Recruiting October 2023 United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact ?? ?? spihapau@mdanderson.org Less <<
NCT03289039 Breast Cancer Phase 2 Recruiting March 31, 2025 United States, Indiana ... More >> Indiana University Recruiting Indianapolis, Indiana, United States, 46202 Contact: Tarah Ballinger, MD ?? ?? Tarahb@iu.edu ?? Principal Investigator: Tarah Ballinger, MD ?? ?? ?? United States, Maine Eastern Maine Medical Center Recruiting Brewer, Maine, United States, 04412 Contact: Sarah Sinclair, MD ?? ?? ssinclair@emhs.org ?? United States, Massachusetts Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Heather A. Parsons, MD ?? ?? HeatherA_Parsons@dfci.harvard.edu ?? Principal Investigator: Heather A. Parson, MD ?? ?? ?? United States, New Hampshire Dana-Farber/New Hampshire Oncology-Hematology Recruiting Londonderry, New Hampshire, United States, 03053 Contact: Fred Briccetti, MD ?? ?? fred_briccetti@dfci.harvard.edu ?? Principal Investigator: Fred Briccetti, MD ?? ?? ?? United States, Ohio The Ohio State University Recruiting Columbus, Ohio, United States, 43210 Contact: Robert Wesolowski, MD ?? ?? Robert.Wesolowski@osumc.edu ?? United States, Texas UT Southwestern Recruiting Dallas, Texas, United States, 75390 Contact: Barbara Haley, MD ?? ?? barbara.haley@utsouthwestern.edu Less <<
NCT01808573 HER2+ Metastatic Breast Cancer... More >> (MBC) Less << Phase 3 Active, not recruiting February 2019 -
NCT02932280 Solid Tumor|Central Nervous Sy... More >>stem Tumor|Lymphoma|Leukemia Less << PHASE1|PHASE2 ACTIVE_NOT_RECRUITING 2025-10-25 Phoenix Children'S Hospital, P... More >>hoenix, Arizona, 85016, United States|Arkansas Children's Hospital, Little Rock, Arkansas, 72206, United States|Stanford University School of Medicine and Stanford Cancer Institute, Palo Alto, California, 94304, United States|Arnold Palmer Hospital for Children, Orlando, Florida, 32806, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Pennsylvania State Hershey Children's Hospital, Hershey, Pennsylvania, 17033, United States|University of Texas, San Antonio, Texas, 78229, United States|Huntsman Cancer Institue, Salt Lake City, Utah, 84113, United States|Alberta Children'S Hospital, Calgary, Alberta, T3B 6A8, Canada Less <<
NCT05388149 Breast Cancer|HER2-positive Br... More >>east Cancer Less << PHASE2 RECRUITING 2025-07-26 University Health Network: Pri... More >>ncess Margaret Cancer Centre, Toronto, Ontario, M5G 1Z5, Canada Less <<
NCT05154396 HER2-positive Breast Cancer PHASE2 UNKNOWN 2024-12-31 -
NCT04781374 Metastatic Prostate Adenocarci... More >>noma|Castration-resistant Prostate Cancer|Prostate Cancer|Prostate Cancer Metastatic Less << PHASE2 WITHDRAWN 2021-09-24 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Dana-Farber Cancer Center, Boston, Massachusetts, 02115, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States Less <<
NCT04856475 Breast Cancer|Brain Metastases PHASE2 WITHDRAWN 2021-11-24 -
NCT05491057 Breast Cancer NOT_YET_RECRUITING 2026-06-30 Medical Affair, Shanghai, Chin... More >>a Less <<
NCT04388384 Breast Neoplasm ACTIVE_NOT_RECRUITING 2025-01-25 Clinic, Klagenfurt, K?rnten, 9... More >>020, Austria|Clinic, V?cklabruck, Ober?sterreich, 4840, Austria|Clinic, Schwarzach im Pongau, Salzburg, 5620, Austria|Clinic, Graz, Steiermark, 8036, Austria|Clinic, Salzburg, 5020, Austria|Clinic, Vienna, 1090, Austria|Clinic, Vienna, 1140, Austria|Clinic, Wien, 1090, Austria|Medical Practice, Heidelberg, Baden Wuerttemberg, 69115, Germany|Community Health Center, Freiburg, Baden-Wuerttemberg, 79110, Germany|Medical Practice, Heidenheim, Baden-Wuerttemberg, 89522, Germany|Clinic, Schw?bisch Hall, Baden-Wuerttemberg, 74523, Germany|Medical Practice, Villingen-Schwenningen, Baden-Wuerttemberg, 78052, Germany|Clinic, Weinheim, Baden-Wuerttemberg, 69469, Germany|Clinic, Baden-Baden, Baden-Württemberg, 76532, Germany|Clinic, Nürtingen, Baden-Württemberg, 72622, Germany|Oncology Center, Offenburg, Baden-Württemberg, 77654, Germany|Clinic, Winnenden, Baden-Württemberg, 71364, Germany|Medical Practice, Aschaffenburg, Bavaria, 63739, Germany|Practice, Augsburg, Bavaria, 86150, Germany|Clinic, Deggendorf, Bavaria, 94469, Germany|Clinic, Landshut, Bavaria, 84034, Germany|Community Health Center, München, Bavaria, 80639, Germany|Clinic, München, Bavaria, 81377, Germany|Clinic, Ansbach, Bayern, 91522, Germany|Clinic, Bamberg, Bayern, 96049, Germany|Community Health Center, Eggenfelden, Bayern, 84307, Germany|Community Health Center, Landshut, Bayern, 84036, Germany|Clinic, Marktredwitz, Bayern, 95615, Germany|Medical Practice, Bad Liebenwerda, Brandenburg, 04924, Germany|Clinic, Neuruppin, Brandenburg, 16816, Germany|Clinic, Potsdam, Brandenburg, 14467, Germany|Clinic, Darmstadt, Hessen, 64283, Germany|Clinic, Frankfurt, Hessen, 65929, Germany|Clinic, Wiesbaden, Hessen, 65189, Germany|Community Health Center, Goslar, Lower Saxony, 38642, Germany|Practice, G?ttingen, Lower Saxony, 37073, Germany|Medical Practice, Hildesheim, Lower Saxony, 31134, Germany|Medical Practice, Leer, Lower Saxony, 26789, Germany|Clinic, Lüneburg, Lower Saxony, 21339, Germany|Medical Practice, Westerstede, Lower Saxony, 26655, Germany|Medical Practice, Wilhelmshaven, Lower Saxony, 26389, Germany|Medical Practice, Greifswald, Meckelnburg-Vorpommern, 17489, Germany|Clinic, Rostock, Mecklenburg-Western Pomerania, 18059, Germany|Medical Practice, Stralsund, Mecklenburg-Western Pomerania, 18435, Germany|Medical Care Center, Georgsmarienhütte, Niedersachsen, 49124, Germany|Clinic, Hannover, Niedersachsen, 30625, Germany|Clinic, Oldenburg, Niedersachsen, 26121, Germany|Medical Practice, Uelzen, Niedersachsen, 29525, Germany|Medical Practice, Bonn, Nordrhein-Westfalen, 53123, Germany|Medical Practice, Bottrop, Nordrhein-Westfalen, 46236, Germany|Clinic, Datteln, Nordrhein-Westfalen, 45711, Germany|Clininc, Essen, Nordrhein-Westfalen, 45138, Germany|Medical Practice, Gütersloh, Nordrhein-Westfalen, 33332, Germany|Clinic, Hamm, Nordrhein-Westfalen, 45711, Germany|Clinic, K?ln, Nordrhein-Westfalen, 50931, Germany|Clinic, K?ln, Nordrhein-westfalen, 51067, Germany|Medical Practice, Moers, Nordrhein-Westfalen, 47441, Germany|Medical Practice, Mülheim/Ruhr, Nordrhein-Westfalen, 45468, Germany|Community Health Center, Soest, Nordrhein-Westfalen, 59494, Germany|Community Health Center, Neuss, North Rhine-Westphalia, 41462, Germany|Medical Practice, Troisdorf, North Rhine-Westphalia, 53840, Germany|Clinic, Witten, North Rhine-Westphalia, 58452, Germany|Medical Practice, Mayen, Rheinland-Pfalz, 56727, Germany|Clinic, Neustadt, Rheinland-Pfalz, 67434, Germany|Medical Practice, Burg, Sachsen-Anhalt, 39288, Germany|Clinic, Magdeburg, Sachsen-Anhalt, 39108, Germany|Clinic, Quedlinburg, Sachsen-Anhalt, 06484, Germany|Clinic, Salzwedel, Sachsen-Anhalt, 29410, Germany|Clinic, Stendal, Sachsen-Anhalt, 39576, Germany|Clinic, Chemnitz, Sachsen, 09116, Germany|Oncology Center, Dresden, Sachsen, 01127, Germany|Medical Praxis, Freital, Sachsen, 01705, Germany|Clinic, Leipzig, Sachsen, 04129, Germany|Medical Practice, Plauen, Sachsen, 08525, Germany|Medical Practice, Halle Saale, Saxony-Anhalt, 06110, Germany|Clinic, Eutin, Schleswig-Holstein, 23701, Germany|Medical Care center, Neuwied, Theinland-Pfalz, 56564, Germany|Medical Practice, Hildburghausen, Thuringia, 98646, Germany|Medical Practice, Erfurt, Thüringen, 99084, Germany|Clinic, Jena, Thüringen, 07747, Germany|Medical Practice, Meiningen, Thüringen, 98617, Germany|Oncology Center, Neuhaus Am Rennweg, Thüringen, 98724, Germany|Medical Care Center, Saalfeld, Thüringen, 07318, Germany|Clinic, Suhl, Thüringen, 98527, Germany|Medical Practice, Suhl, Thüringen, 98527, Germany|Medical Practice, Berlin, 10367, Germany|Clinical Practice, Berlin, 13156, Germany|Medical Practice, Berlin, 14169, Germany|Medical Practice, Bremen, 28209, Germany|Clinic, Bremen, 28239, Germany|Oncology Center, Hamburg, 22307, Germany|Practice, Basel, Basel Stadt, 4051, Switzerland|Practice, Biel, Bern, 2502, Switzerland|Clinic, Chur, Graubünden, 7000, Switzerland|Clinic, Olten, Solothurn, 4600, Switzerland|Clinic, Lausanne, Vaud, 1003, Switzerland|Clinic, Zürich, 8008, Switzerland Less <<
NCT03812393 Triple Negative Breast Cancer|... More >>Early-stage Breast Cancer|HER2-positive Breast Cancer Less << PHASE2 ACTIVE_NOT_RECRUITING 2024-12-15 West Cancer Center, Germantown... More >>, Tennessee, 38139, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

8.98mL

1.80mL

0.90mL

17.95mL

3.59mL

1.80mL

References

 

Historical Records

Categories