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[Example 68] 3-((2R)-1-[((2S)-1'-{2-[(2R)-4-[3,5-bis(Trifluoromethyl)benzoyl]-2-(3,4-dichlorophenyl)morpholin-2-yl]ethyl}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-yl)oxy]acetyl}pyrralidin-2-yl)propan-1-ol hydrochloride (Exemplary compound No. 2-574 hydrochloride) [Example 68a] Benzyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 2 g (0.0198 mol) of (2R)-pyrrolidin-2-ylmethanol was dissolved in 20 mL of ethyl acetate, 20 mL of water was added thereto, and the mixture was stirred. 3.3 g (0.30 mol) of sodium hydrogencarbonate was added to the mixture, followed by stirring of the mixture for 5 minutes. 4.24 mL (0.03 mol) of benzyl chloroformate was added dropwise to the mixture, followed by stirring for 5 hours. After the ethyl acetate layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure to quantitatively obtain the title compound. 1H-NMR spectrum (500 MHz, CDCl3) delta ppm: 7.55-7.28 (5H, m), 5.16 (2H, s), 4.12-3.90 (1H, br), 3.83-3.33 (4H, m), 2.19-1.51 (4H, m).
In diethyl ether;
EXAMPLE 51 (R)-2-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinecaboxylic acid phenylmethyl ester The title compound is prepared by the procedure of Example 50 using 20.0 g of (R)-2-pyrrolidinemethanol, 44.0 g of benzyl chloroformate and 200 ml of diethyl ether to give 56.4 g of (R)-2-hydroxymethyl-1-pyrrolidine carboxylic acid phenyl methyl ester.
a [(2R)-1-(2-Methoxy-5-Nitrobenzyl)Pyrrolidinyl]Methanol Hydrochloride To <strong>[3913-23-3]2-methoxy-5-nitrobenzyl bromide</strong> (6.11 g, 24.8 mmol) dissolved in N,N-dimethylformamide (25 mL) was added Hunig's base (3.5 g, 27.2 mmol) followed by R-(-)-2-pyrrolidinemethanol (2.4 g, 24.8 mmol) and the reaction mixture was stirred at room temperature for 16 h. The N,N-dimethylformamide was removed, the residue treated with water (100 mL) followed by aqueous ammonium hydroxide until basic and extracted with ethyl acetate (3*100 mL). The ethyl acetate extracts were combined, washed with water (3*100 mL), dried over magnesium sulphate, filtered, and evaporated to give the free base of the title compound as a yellow oil (6.0 g). Treatment of an ethanol solution of the free base with ethanol/hydrogen chloride afforded the title compound (7.4 g, 95%) as a light yellow solid; MS: m/z 267 [M+H]+.
In 1,4-dioxane; at 70 - 80℃; for 12 - 48h;Combinatorial reaction / High throughput screening (HTS);
Example 1. Preparation of a combinatorial library of substituted 2-aminomethyl-5-hydroxy-1H-indole-3-carboxylic acids esters of general formula 1.1. A mixture of 0.357 mmol of ester 2, 0.43 mmol of a secondary amine 3, and 0.43 mmol of formaldehyde in the form of formalin in 3 ml of dioxane is heated at 70-80°C at stirring for 12 to 48 hours. Progress of the reaction is monitored by chromato-mass-spectrometry. Upon completion of the reaction, the reaction mass is diluted with water, the residue is filtered and recrystallized from a suitable solvent, or purified by chromatography.
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