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EXAMPLE 2; [0292] In this Example, the modafinil intermediate benzhydrylthioacetamide was oxidized on a commercial scale to produce modafinil according to the processes described herein.[0293] First, benzhydrylthioacetamide (100 g; MW = 257.35, 1.0 eq.) was charged to a reaction chamber. The reaction chamber was purged with about 5 psig N2 and vented through chemical scrubber. Approximately 155 kg of methanol (1.50-1.67 kg/kg benzhydrylthioacetamide) was then charged to the reaction chamber. The temperature of the reaction chamber was adjusted to about 30C-40C and the resulting mixture was agitated at about 70-90 RPM.[ 0294 ] Next, approximately 0.70 kg of acetic acid (0.68-0.72 kg/kg benzhydrylthioacetamide) was charged to the reaction chamber. The resulting mixture was then stirred for about 15 minutes, and the temperature was maintained at about 30C-40C.[ 0295 ] To the benzhydrylthioacetamide/methanol/acetic acid mixture was then added approximately 0.472 kg of 30% hydrogen peroxide (0.448-0.496 kg/kg benzhydrylthioacetamide) at a rate of about 1-2 kg/min. The resulting mixture was then heated to and maintained at about 38C- 43C and stirred for about 24 hours.[ 0296 ] After about 24 hours, the reaction mixture was cooled to about 20C-30C and the reaction chamber was pressurized to about 3-7 psig with N2 and vented through a chemical scrubber. The reaction mixture was further cooled to about 0"C-5C and stirred for about 2 hours. The reaction mixture was then charged to an N2-purged centrifuge (<7% O2 content). The centrifuge was cycled on low speed until the centrifuge basket was less than 3/4 full with the crude modafinil product (-15 minutes). The centrifuge load was washed with about 113 liters of cool methanol, and the crude modafinil cake was deliquored at high speed centrifugation for about 15-30 minutes.[0297] The white- to off-white crude modafinil product (-85.2 kg) was then loaded onto a TeflonO-lined tray and dried at about 60C-70C for at least about 6 hours (6-24 hours). After drying, a 5-10 gram sample was analyzed by HPLC. The results are illustrated in Table 8, below: <n="43"/>Table 8
EXAMPLE 2; [0292] In this Example, the modafinil intermediate benzhydrylthioacetamide was oxidized on a commercial scale to produce modafinil according to the processes described herein.[0293] First, benzhydrylthioacetamide (100 g; MW = 257.35, 1.0 eq.) was charged to a reaction chamber. The reaction chamber was purged with about 5 psig N2 and vented through chemical scrubber. Approximately 155 kg of methanol (1.50-1.67 kg/kg benzhydrylthioacetamide) was then charged to the reaction chamber. The temperature of the reaction chamber was adjusted to about 30C-40C and the resulting mixture was agitated at about 70-90 RPM.[ 0294 ] Next, approximately 0.70 kg of acetic acid (0.68-0.72 kg/kg benzhydrylthioacetamide) was charged to the reaction chamber. The resulting mixture was then stirred for about 15 minutes, and the temperature was maintained at about 30C-40C.[ 0295 ] To the benzhydrylthioacetamide/methanol/acetic acid mixture was then added approximately 0.472 kg of 30% hydrogen peroxide (0.448-0.496 kg/kg benzhydrylthioacetamide) at a rate of about 1-2 kg/min. The resulting mixture was then heated to and maintained at about 38C- 43C and stirred for about 24 hours.[ 0296 ] After about 24 hours, the reaction mixture was cooled to about 20C-30C and the reaction chamber was pressurized to about 3-7 psig with N2 and vented through a chemical scrubber. The reaction mixture was further cooled to about 0"C-5C and stirred for about 2 hours. The reaction mixture was then charged to an N2-purged centrifuge (<7% O2 content). The centrifuge was cycled on low speed until the centrifuge basket was less than 3/4 full with the crude modafinil product (-15 minutes). The centrifuge load was washed with about 113 liters of cool methanol, and the crude modafinil cake was deliquored at high speed centrifugation for about 15-30 minutes.[0297] The white- to off-white crude modafinil product (-85.2 kg) was then loaded onto a TeflonO-lined tray and dried at about 60C-70C for at least about 6 hours (6-24 hours). After drying, a 5-10 gram sample was analyzed by HPLC. The results are illustrated in Table 8, below: <n="43"/>Table 8
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