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Chemical Structure| 67909-49-3 Chemical Structure| 67909-49-3

Structure of Dehydroevodiamine
CAS No.: 67909-49-3

Chemical Structure| 67909-49-3

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CAS No.: 67909-49-3

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Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

Synonyms: DHED

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Product Details of Dehydroevodiamine

CAS No. :67909-49-3
Formula : C19H15N3O
M.W : 301.34
SMILES Code : O=C1N2C(C([N-]C3=C4C=CC=C3)=C4CC2)=[N+](C)C5=C1C=CC=C5
Synonyms :
DHED
MDL No. :MFCD11656140
InChI Key :VXHNSVKJHXSKKM-UHFFFAOYSA-N
Pubchem ID :9817839

Safety of Dehydroevodiamine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H317
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Dehydroevodiamine

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.32mL

0.66mL

0.33mL

16.59mL

3.32mL

1.66mL

33.19mL

6.64mL

3.32mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

[1]Shin KY, Kim KY, Suh YH. Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models. Korean J Physiol Pharmacol. 2017 Jan;21(1):55-64.

[2]Shin KY, Noh SJ, et al. Dehydroevodiamine?HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a γ-Secretase Inhibitor. CNS Neurol Disord Drug Targets. 2016;15(8):935-944.

[3]Loh SH, Tsai YT, Lee CY, Chang CY, Tsai CS, Cheng TH, Lin CI. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J Ethnopharmacol. 2014 May 14;153(3):753-62

[4]Noh EJ, Ahn KS, Shin EM, Jung SH, Kim YS. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages. Life Sci. 2006 Jul 10;79(7):695-701

[5]Wang HH, Chou CJ, Liao JF, Chen CF. Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5

[6]Shin KY, Kim KY, Suh YH. Dehydroevodiamine?HCl enhances cognitive function in memory-impaired rat models. Korean J Physiol Pharmacol. 2017 Jan;21(1):55-64

[7]Peng JH, Zhang CE, Wei W, Hong XP, Pan XP, Wang JZ. Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats. Neuropharmacology. 2007 Jun;52(7):1521-7

[8]Fang J, Liu R, Tian Q, Hong XP, Wang SH, Cao FY, Pan XP, Wang JZ. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices. Acta Pharmacol Sin. 2007 Nov;28(11):1717-23

 

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