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Chemical Structure| 674792-05-3 Chemical Structure| 674792-05-3

Structure of 674792-05-3

Chemical Structure| 674792-05-3

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CAS No.: 674792-05-3

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Product Details of [ 674792-05-3 ]

CAS No. :674792-05-3
Formula : C12H24N2O2
M.W : 228.33
SMILES Code : CC([C@@H]1N(C(OC(C)(C)C)=O)CCNC1)C
MDL No. :MFCD03787918
InChI Key :NZTWGWFHWJARJX-SNVBAGLBSA-N
Pubchem ID :17750439

Safety of [ 674792-05-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 674792-05-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 674792-05-3 ]

[ 674792-05-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 674792-05-3 ]
  • [ 773134-43-3 ]
  • (S)-tert-butyl 2-isopropyl-4-(4-(methoxycarbonyl)-3-(methylsulfonyl)phenyl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos; In toluene; at 100℃;Inert atmosphere; [00339] To a solution of (5)-tert-butyl 2-isopropylpiperazine-1-carboxylate (400 mg, 1.76 mmol) in anhydrous toluene (10 mL) was added <strong>[773134-43-3]methyl 4-bromo-2-(methylsulfonyl)benzoate</strong> (1.03 g, 4.8 mmol), X-phos (80 mg, 0.17 mmol), Cs2CO3 (1.50 g, 4.62 mmol) and Pd2(dba)3 (200 mg, 0.22 mmol) under N2. The reaction mixture was stirred at 100 oC overnight. The reaction was quenched with water (20 mL), and extracted with EtOAc (4 X 20 mL). The combined organic layers were dried over anhydrous Na2504, filtered, concentrated and then purified by preparative TLC with petroleum ether / EtOAc 5/1 to afford (5)-tert-butyl 2- isopropyl-4- (4- (methoxycarbonyl)-3- (methylsulfonyl)phenyl)piperazine- 1 -carboxylate (500 mg, 65% yield) as a grey solid.
 

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[ 674792-05-3 ]

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Piperazines

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