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Quality Control of [ 66684-58-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 66684-58-0 ]

SDS Specification

Alternatived Products of [ 66684-58-0 ]

Product Details of [ 66684-58-0 ]

CAS No. :	66684-58-0	MDL No. :	MFCD00456803
Formula :	C₆H₂F₃NO₂	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	PTTUMBGORBMNBN-UHFFFAOYSA-N
M.W :	177.08	Pubchem ID :	2782793
Synonyms :

Calculated chemistry of [ 66684-58-0 ] Expand+

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	5.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.14
TPSA :	45.82 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.85 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.29
Log Po/w (XLOGP3) :	2.16
Log Po/w (WLOGP) :	3.27
Log Po/w (MLOGP) :	2.17
Log Po/w (SILICOS-IT) :	1.0
Consensus Log Po/w :	1.98

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.6
Solubility :	0.442 mg/ml ; 0.0025 mol/l
Class :	Soluble
Log S (Ali) :	-2.75
Solubility :	0.311 mg/ml ; 0.00176 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.61
Solubility :	0.431 mg/ml ; 0.00243 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	3.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.86

Safety of [ 66684-58-0 ]

Signal Word:	Danger	Class:	6.1
Precautionary Statements:	P301+P330+P331-P312-P280-P302+P352-P304+P340-P337+P313	UN#:	2810
Hazard Statements:	H301+H311+H331-H315-H319	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 66684-58-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 66684-58-0 ]
Downstream synthetic route of [ 66684-58-0 ]

[ 66684-58-0 ] Synthesis Path-Upstream 1~2

1
[ 5580-79-0 ]
[ 66684-57-9 ]
[ 66684-58-0 ]

Reference： [1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 8, p. 1529 - 1541
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3203 - 3207[3] Angew. Chem., 2013, vol. 125, # 11, p. 3285 - 3289,5

2
[ 880-78-4 ]
[ 66684-57-9 ]
[ 66684-58-0 ]

Reference： [1] Advanced Synthesis and Catalysis, 2012, vol. 354, # 8, p. 1529 - 1541
[2] Advanced Synthesis and Catalysis, 2012, vol. 354, # 8, p. 1529 - 1541
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3203 - 3207[4] Angew. Chem., 2013, vol. 125, # 11, p. 3285 - 3289,5
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 11, p. 3203 - 3207[6] Angew. Chem., 2013, vol. 125, # 11, p. 3285 - 3289,5

[ 66684-58-0 ] Synthesis Path-Downstream 1~7

1
[ 130596-62-2 ]
[ 66684-58-0 ]
[ 1430321-66-6 ]

Yield	Reaction Conditions	Operation in experiment
63%		To a solution of 4,4-dimethyl- 1 ,4-azasilinane hydrochloride 4 (950 mg, 7.35 mmol) in EtOAc (15 mL), triethylamine (2.5 mL, 18.37 mmol) is added and stirred at 25 C for 10 min. The reaction mixture is cooled to 0 C and l,2,3-trifiuoro-5-nitrobenzene (1.29 g, 7.35 mmol) is added drop wise and allowed to stir at 25 C for 6 h. Water is then added and the organic layer is separated. The aqueous layer is extracted with EtOAc (2 X 10 mL) and the solvent is removed under reduced pressure. The product obtained is purified by column chromatography using hexane-EtOAc mixtures to give the product as a crystalline yellow solid 9a (1.32 g) in 63% yield. 1H NMR (400 MHz, CDC13): delta 7.77-7.69(m, 2H), 3.5 l(t, J=6.28 Hz, 4H), 0.90(t, J=6.28 Hz, 4H), 0.12(s, 6H). 13C NMR (50 MHz, CDC13): delta 155.05(dd, J=248.5 Hz, 8.40 Hz), 108.9(m), 138.96(d, J=10.98 Hz), 136.73(t, J=12.44 Hz), 51.04(t, J=4.02 Hz), 15.15, -3.07. IR: 1606, 1515, 1335, 1216, 1110, 758 cm 1.
63%		To a solution of <strong>[130596-62-2]4,4-dimethyl-1,4-azasilinane hydrochloride</strong> 4 (950 mg, 7.35 mmol) in EtOAc (15 mL), triethylamine (2.5 mL, 18.37 mmol) is added and stirred at 25 C. for 10 min. The reaction mixture is cooled to 0 C. and 1,2,3-trifluoro-5-nitrobenzene (1.29 g, 7.35 mmol) is added drop wise and allowed to stir at 25 C. for 6 h. Water is then added and the organic layer is separated. The aqueous layer is extracted with EtOAc (2*10 mL) and the solvent is removed under reduced pressure. The product obtained is purified by column chromatography using hexane-EtOAc mixtures to give the product as a crystalline yellow solid 9a (1.32 g) in 63% yield. 1H NMR (400 MHz, CDCl3): delta 7.77-7.69 (m, 2H), 3.51 (t, J=6.28 Hz, 4H), 0.90 (t, J=6.28 Hz, 4H), 0.12 (s, 6H). 13C NMR (50 MHz, CDCl3): delta 155.05 (dd, J=248.5 Hz, 8.40 Hz), 108.9 (m), 138.96 (d, J=10.98 Hz), 136.73 (t, J=12.44 Hz), 51.04 (t, J=4.02 Hz), 15.15, -3.07. IR: 1606, 1515, 1335, 1216, 1110, 758 cm-1.
31.2 g		4,4-Dimethyl azasilinane hydrochloride (20.6 g, 124.4 mmol) and triethylamine (51.6 g, 3373.0 mmol) were dispersed in N,N-dimethylformamide (200 mL). The resulting mixture was stirred at room temperature for 10 min, and then transferred to an ice water bath and stirred. 3,4,5-Trifluoronitrobenzene (20.0 g, 113.0 mmol) was added dropwise. After the completion of the dropwise addition, the resulting mixture was stirred for 30 min in an ice water bath, and then stirred at room temperature overnight. Then the reaction mixture was poured into 1 L of water, stirred for 10 min, suction-filtered, washed with water (10 mL*3), and dried to give 1-(2,6-difluoro-4-nitrophenyl)-4,4-dimethyl-1,4-azasilinane (31.2 g). 1H NMR (500 MHz, DMSO-d6): delta7.93 (dd, J=10.0 Hz, 1.0 Hz, 2H), 3.49-3.51 (m, 4H), 0.85-0.88 (m, 4H), 0.12 (s, 6H).

Reference： [1]ACS Medicinal Chemistry Letters,2015,vol. 6,p. 1105 - 1110
[2]Patent: WO2013/54275,2013,A1 .Location in patent: Page/Page column 31
[3]Patent: US2014/296133,2014,A1 .Location in patent: Paragraph 0131
[4]Patent: US2020/17532,2020,A1 .Location in patent: Paragraph 0139-0142

2
[ 66684-58-0 ]
[ 498-63-5 ]
[ 1542258-95-6 ]

Yield	Reaction Conditions	Operation in experiment
93%	With potassium hydroxide; In dimethyl sulfoxide; at 65℃; for 4h;	To a suspension of <strong>[498-63-5]prolinol</strong> (2.74 g, 27.11 mmol) and KOH (3.17 g, 56.47 mmol) in DMSO (30 mL) was added 1,2,3-trifluoro-5-nitrobenzene (4.00 g, 22.59 mmol) at a The reaction mixture was heated at 65 °C for 4 h. The mixture was diluted with water (150 mL) and extracted with CH2C12 (100 mL x 2). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid(5.00 g, 93percent).
93%	With potassium hydroxide; In dimethyl sulfoxide; at 65℃; for 4h;	To a suspension of <strong>[498-63-5]prolinol</strong> (2.74 g, 27.11 mmol) and KOH (3.17 g, 56.47 mmol) in DMSO (30 mL) was added 1,2,3-trifluoro-5-nitrobenzene (4.00 g, 22.59 mmol) at rt. The reaction mixture was heated at 65° C. for 4 h. The mixture was diluted with water (150 mL) and extracted with CH2Cl2 (100 mL*2). The combined organic phases were dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a yellow solid (5.00 g, 93percent).
93%	With potassium hydroxide; In dimethyl sulfoxide; at 65℃; for 4h;	3,4,5-trifluoronitrobenzene (4.00 g, 22.59 mmol) was added to contain <strong>[498-63-5]prolinol</strong> (2.74 g, 27.11 mmol)A suspension of KOH (3.17 g, 56.47 mmol) in DMSO (30 mL) was then warmed to 65[deg.] C. and stirred for 4 h.The reaction was completed, cooled to room temperature, added with water (150 mL), and extracted with dichloromethane (100 mL x 2).The organic phases were combined and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave a yellow solid (5.00 g, 93percent).

Reference： [1]Patent: WO2014/12360,2014,A1 .Location in patent: Paragraph 00296
[2]Patent: US2015/87639,2015,A1 .Location in patent: Paragraph 0555
[3]Patent: TWI607995,2017,B .Location in patent: Page/Page column 129

3
[ 66684-58-0 ]
[ 23156-27-6 ]

Yield	Reaction Conditions	Operation in experiment
31%	With ammonia; In methanol; at 80℃; for 48h;	A solution of 3, 4, 5-trifluoro-1 -nitrobenzene (5 g, 28.4 mmol) in a 7N ammonia methanolic solution (30 mL) was stirred at 80 ^ for 2 days. After the mixture was allowed to cool down, water (50 mL) was added and the washed with ethyl acetate (3X100 mL). The organic phases were combined and washed with water (2X50 mL), dried over MgS04 and concentrated under reduced pressure. The product was purified by flash silica chromatography (ethyl acetate : hexane = 20 : 80) to afford 2,6-difluoro- 4-nitroaniline (1 .53 g, 31 %). ESI-MS m/z: 196 ([M+Na]+ , 100%); H NMR (600 MHz, DMSO-d6) delta ppm: 7.82-7-95 (m, 2 H), 6.86 (s, 2 H).

Reference： [1]Patent: WO2014/122303,2014,A1 .Location in patent: Page/Page column 28

4
[ 66684-58-0 ]
[ 21642-98-8 ]
1-(2,6-difluoro-4-nitrophenyl)-4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
3.75 mg	With potassium carbonate; In N,N-dimethyl-formamide; at 10 - 35℃; for 2.0h;	A mixture of <strong>[21642-98-8]4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile</strong> (2.00 g), 1,2,3-trifluoro-5-nitrobenzene (3.54 g), potassium carbonate (3.73 g) and N,N-dimethylformamide (20 mL) was stirred at room temperature for 2 hr. The reaction mixture was slowly poured into saturated sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. To the residue was added a mixed solvent (10 mL) of isopropyl ether/ethyl acetate =4/1, and the mixture was stirred for 15 min. The precipitate was collected by filtration to give the title compound (3.75 g). MS (ESI+): [M+H]+ 308.2.

Reference： [1]Patent: EP2818473,2014,A1 .Location in patent: Paragraph 0784

5
[ 280-13-7 ]
[ 66684-58-0 ]
3-(2,6-difluoro-4-nitrophenyl)-8-oxa-3-azabicyclo[3.2.1]octane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With potassium carbonate; In N,N-dimethyl-formamide; at 25 - 80℃; for 2h;Inert atmosphere;	To a solution of <strong>[280-13-7]8-oxa-3-aza-bicyclo[3.2.1]octane</strong> (1) (5.0 g, 44.2 mmol) and 1,2,3-trifluoro-5-nitrobenzene (8.6 g, 48.6 mmol) in DMF (10 mL) was added K2C03 (12.2 g, 88.4 mmol) at 25C then the reaction mixture was stirred at 80C for 2 h under a nitrogen gas atmosphere, monitored by TLC. The mixture was concentrated under reduced pressure, and the crude material was purified by silica gel column chromatography (EA: PE = 3: 1) to afford 3 -(2,6-difluoro-4-nitrophenyl)-8-oxa-3 -aza-bicyclo[3 .2.1 ]octane (3) (9.3 g, 78%) as a yellow solid.LC-MS (ESI) m/z = 271 [M+H].

Reference： [1]Patent: WO2017/15106,2017,A1 .Location in patent: Page/Page column 146

6
[ 280-13-7 ]
[ 66684-58-0 ]
8-(2,6-difluoro-4-nitrophenyl)-3-oxa-8-aza-bicyclo[3.2.1]octane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	With potassium carbonate; In N,N-dimethyl-formamide; at 25 - 80℃; for 2h;Inert atmosphere;	To a solution of 3-oxa-8-aza-bicyclo[3.2.1]octane (1) (5.0 g, 44.2 mmol) and1,2,3-trifluoro-5-nitrobenzene (8.6 g, 48.6 mmol) in DMF (10 mL) was addedK2C03 (12.2 g, 88.4 mmol) at 25C then the reaction mixture was stirred at 80C for 2 h under a nitrogen gas atmosphere, monitored by TLC. The mixture was concentrated under reduced pressure, and the crude material was purified by silica gel column chromatography (EA: PE = 3: 1) to afford8-(2,6-difluoro-4-nitrophenyl)-3 -oxa-8-aza-bicyclo[3 .2.1 ]octane (3) (9.3 g, 78%) as a yellow solid.LC-MS (ESI) m/z = 271 [M+H].

Reference： [1]Patent: WO2017/15106,2017,A1 .Location in patent: Page/Page column 158; 159

7
[ 66684-58-0 ]
[ 74420-02-3 ]
4-(2,6-difluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
52%	With potassium carbonate; In dimethyl sulfoxide; at 20℃; for 1.0h;	A solution of 1 ,2,3-trifluoro-5-nitrobenzene (CAS No. [66684-58-0]; 3.59 g, 20.3 mmol) and 1 H- pyrrolo[2,3-b]pyridin-4-ol (CAS No. [74420-02-3]; 1 .10 eq., 2.99 g, 22.3 mmol) in DMSO (65 mL) was treated with potassium carbonate (4.00 eq, 1 1 .2 g, 81.1 mmol) and stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate (500 mL) and washed with water (3 x 200 mL) and brine (150 mL), dried with sodium sulfate and concentrated in vacuo. The obtained material was purified by flash chromatography (S1O2- hexane/ ethyl acetate) to give the title compound (3.1 g, 52percent). LC-MS (method 2): Rt = 1 .13 min; MS (ESIpos): m/z = 292 [M+H]+. 1H-NMR (400 MHz, DMSO-d6) delta [ppm] = 6.35 (d, 1 H), 6.59 (d, 1 H), 7.47 (d, 1 H), 8.13 (d, 1 H), 8.37 - 8.43 (m, 2H), 1 1 .97 (br s, 1 H).
52%	With potassium carbonate; In dimethyl sulfoxide; at 20℃; for 1.0h;	A solution of 1 ,2,3-trifluoro-5-nitrobenzene (CAS No. [66684-58-0]; 3.59 g, 20.3 mmol) and 1 H- pyrrolo[2,3-b]pyridin-4-ol (CAS No. [74420-02-3]; 1 .10 eq., 2.99 g, 22.3 mmol) in DMSO (65 mL) was treated with potassium carbonate (4.00 eq, 1 1.2 g, 81.1 mmol) and stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate (500 mL) and washed with water (3 x 200 mL) and brine (150 mL), dried with sodium sulfate and concentrated in vacuo. The obtained material was purified by flash chromatography (S1O2- hexane/ ethyl acetate) to give the title compound (3.1 g, 52percent). LC-MS (Method 2): Rt = 1 .13 min; MS (ESIpos): m/z = 292 [M+H]+. 1H-NMR (400 MHz, DMSO-d6) delta [ppm] = 6.35 (d, 1 H), 6.59 (d, 1 H), 7.47 (d, 1 H), 8.13 (d, 1 H), 8.37 - 8.43 (m, 2H), 1 1 .97 (br s, 1 H).

Reference： [1]Patent: WO2018/228920,2018,A1 .Location in patent: Page/Page column 187
[2]Patent: WO2019/16071,2019,A1 .Location in patent: Page/Page column 105

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? Alkyl Halide Occurrence ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Friedel-Crafts Reaction ? Hydrogenolysis of Benzyl Ether ? Preparation of Alkylbenzene ? Reactions of Benzene and Substituted Benzenes ? Vilsmeier-Haack Reaction

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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 66684-58-0 ] {[proInfo.proName]}

Quality Control of [ 66684-58-0 ]

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Calculated chemistry of [ 66684-58-0 ] Expand+

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Medicinal Chemistry

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Application In Synthesis of [ 66684-58-0 ]

[ 66684-58-0 ] Synthesis Path-Upstream 1~2

[ 66684-58-0 ] Synthesis Path-Downstream 1~7

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Fluorinated Building Blocks

Aryls

Nitroes

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[ 66684-58-0 ]