成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 65673-63-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 65673-63-4
Chemical Structure| 65673-63-4
Structure of 65673-63-4 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 65673-63-4 ]

Related Doc. of [ 65673-63-4 ]

Alternatived Products of [ 65673-63-4 ]
Product Citations

Product Details of [ 65673-63-4 ]

CAS No. :65673-63-4 MDL No. :MFCD00218213
Formula : C17H17BrN2O5 Boiling Point : -
Linear Structure Formula :- InChI Key :SXJDCULZDFWMJC-UHFFFAOYSA-N
M.W : 409.23 Pubchem ID :3549
Synonyms :
Chemical Name :rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative)

Calculated chemistry of [ 65673-63-4 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 25
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.35
Num. rotatable bonds : 7
Num. H-bond acceptors : 6.0
Num. H-bond donors : 1.0
Molar Refractivity : 91.3
TPSA : 111.64 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : Yes
CYP2C9 inhibitor : Yes
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -6.67 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.71
Log Po/w (XLOGP3) : 3.0
Log Po/w (WLOGP) : 2.36
Log Po/w (MLOGP) : 1.44
Log Po/w (SILICOS-IT) : 2.54
Consensus Log Po/w : 2.41

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -3.98
Solubility : 0.0426 mg/ml ; 0.000104 mol/l
Class : Soluble
Log S (Ali) : -5.01
Solubility : 0.00401 mg/ml ; 0.0000098 mol/l
Class : Moderately soluble
Log S (SILICOS-IT) : -4.21
Solubility : 0.0251 mg/ml ; 0.0000614 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 4.28

Safety of [ 65673-63-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 65673-63-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65673-63-4 ]

[ 65673-63-4 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 105-56-6 ]
  • [ 1761-61-1 ]
  • [ 65673-63-4 ]
YieldReaction ConditionsOperation in experiment
94% With N,N,N',N'-tetramethylguanidine; In neat liquid; at 20℃; for 0.583333h; General procedure: TMG (3.5 mmol) was added to a mixture of SA (1 mmol), MN (1 mmol) and DAP (1 mmol) in neat condition. The resulting mixture was stirred at room temperature. After completion of the reaction (monitored by TLC), distilled water (15 mL) was added to the reaction mixture and stirring continued till a free flowing solid was obtained. It was filtered and then washed successively with water, n-hexane. The crude product was purified by recrystallization from ethanol solution. For this, the crude product was saturated in boiling ethanol and then the solution mixture was filtered when it was hot to remove the undissolved solid. The hot filtrate cooled down to room temperature to afford elemental analytically pure crystalline product. The similar experimental procedures were adopted for the synthesis of all the 2-amino-4H-chrormens.
55% In ethanol; at 20℃;Molecular sieve; Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA14-1) was purchased from Wako (Tokyo, Japan) or prepared by following an established procedure [12]. In short, 5-bromosalicylaldehyde was treated with ethyl cyanoacetate in the presence of MS3A in dry ethanol at room temperature to produce HA14-1 with a 55percent yield. Synthesized HA14-1 had inhibitory activity comparable with commercial HA14-1.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;