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[ CAS No. 640735-23-5 ] {[proInfo.proName]}

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Chemical Structure| 640735-23-5
Chemical Structure| 640735-23-5
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Product Details of [ 640735-23-5 ]

CAS No. :640735-23-5 MDL No. :MFCD08272231
Formula : C7H5FN2 Boiling Point : -
Linear Structure Formula :- InChI Key :YZTWCWYRUCKWDR-UHFFFAOYSA-N
M.W : 136.13 Pubchem ID :11297998
Synonyms :

Safety of [ 640735-23-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338-P310 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 640735-23-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 640735-23-5 ]

[ 640735-23-5 ] Synthesis Path-Downstream   1~17

  • 1
  • [ 74420-00-1 ]
  • [ 74420-02-3 ]
  • [ 640735-23-5 ]
  • 2
  • [ 640735-25-7 ]
  • [ 640735-23-5 ]
YieldReaction ConditionsOperation in experiment
94% With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20℃; for 1h;Inert atmosphere; [0722] To a stirred solution of 4-fluoro-i-(triisopropylsilyl)-1H-pyrrolo [2,3-bj pyridine (3 g, 10 mmol) in THF (15 mL) at 0 C under an argon atmosphere was added tetra butyl ammonium fluoride 1M in THF (10.5 mL). The reaction mixture was warmed to room temperature and stirred for 1 h. After consumption of starting material (by TLC), the reactionmixture was diluted with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 20%EtOAc: Hexane to afford 4-fluoro-1H-pyrrolo [2,3-bj pyridine (1.3 g, 94%) as an off-white solid. ?H NMR (CDC13, 400 MHz): 10.52 (brs, 1H), 8.30-8.25 (m, 1H), 7.32-7.30 (m, 1H), 6.81 (dd, 1H), 6.59 (s, 1H); TLC: 20% EtOAc Hexane (R 0.2).
  • 3
  • [ 109-01-3 ]
  • [ 640735-23-5 ]
  • 4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
  • 4
  • [ 31252-42-3 ]
  • [ 640735-23-5 ]
  • C19H21N3 [ No CAS ]
  • 5
  • [ 110-91-8 ]
  • [ 640735-23-5 ]
  • 4-(morpholin-4-yl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
  • 6
  • [ 110-89-4 ]
  • [ 640735-23-5 ]
  • 4-(1-piperidyl)-1H-pyrrolo[2,3-b]pyridine [ No CAS ]
  • 7
  • [ 123-75-1 ]
  • [ 640735-23-5 ]
  • C11H13N3 [ No CAS ]
  • 8
  • [ 319474-34-5 ]
  • [ 640735-23-5 ]
  • 9
  • [ 920501-58-2 ]
  • [ 640735-23-5 ]
  • 14
  • [ 640735-22-4 ]
  • [ 640735-23-5 ]
  • 15
  • [ 808144-32-3 ]
  • [ 640735-23-5 ]
  • [ 849068-01-5 ]
YieldReaction ConditionsOperation in experiment
91% With aluminum (III) chloride; In dichloromethane; for 14h; Example 44 2-(2, 3-DIFLUORO-PHENYL)-1-(4-FLUORO-LH-PYRROLO [2S3-B] PY ridin-3-yl)-ethanone [0256] 4-FLUORO-LH-PYRROLO [2, 3-B] PYRIDINE (230mg, 1. 69MMOL) (ORG. Lett. 2003,5 (26), 5023) and AlCl3 (678, 5. lmmol) in methylene chloride (30mL) were stirred for 0.5hr. To this mixture was added 2,3-Difluoro-phenyl)-acetyl chloride (644mg, 3. 38MMOL) and the reaction solution was stirred for 14HR. Quenched with methanol (50mL) and water (50mL) and extracted with ethyl acetate, dried (NA2SO4). Flash chromatography (methylene chloride/methanol) afforded 2- (2, 3-Difluoro-phenyl)-l- (4-fluoro-lH-pyrrolo [2, 3-B] PY ridin-3-yl)-ethanone (448mg, 91% YIELD). LC/MS : RT 3.16mins. ; m/e 287.1 (M+H), 285.2 (M-H).
  • 16
  • [ 640735-23-5 ]
  • [ 1172067-55-8 ]
YieldReaction ConditionsOperation in experiment
75.2% With nitric acid; at 0℃; for 0.166667h; 00341] 4-Fluoro-lH-pyrrolo[2,3-b]pyridine (1.80 g, 13.2 mmol, prepared as described inThibault, et al. as cited in Scheme 1 above) was added slowly to fuming HNO3 at 00C and stirred for 10 minutes. Ice was then added, followed by the addition of water. The reaction was then filtered, and the solid product was washed with water and dried to give 4-fluoro-3-nitro-lH- pyrrolo[2,3-b]pyridine (1.80 g, 75.2% yield).
  • 17
  • [ 271-63-6 ]
  • [ 640735-23-5 ]
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